Comments regarding errors in component datasets --- Doufas DeRamp Study --- WARNING: This study shows consistent infusion overlap. All infusion rates increased by factor 10. WARNING: more that 1 sec overlapping infusions ID=5004 time=103.500000 stop=109.000000 lastt=79.000000 WARNING: more that 1 sec overlapping infusions ID=5005 time=87.750000 stop=92.250000 lastt=72.250000 A possible explanation of the consistent infusion overlap is if infusion rates are incorrectly noted as ml/min but interpreted as mg/min, assuming propofol 1% --- Doufas Fixed Reduction Study --- WARNING: This study shows consistent infusion overlap. All infusion rates increased by factor 10. WARNING: more that 1 sec overlapping infusions ID=4002 time=216.500000 stop=229.750000 lastt=189.750000 WARNING: more that 1 sec overlapping infusions ID=4003 time=138.250000 stop=140.500000 lastt=102.500000 WARNING: more that 1 sec overlapping infusions ID=4004 time=96.750000 stop=98.464286 lastt=72.750000 WARNING: more that 1 sec overlapping infusions ID=4007 time=202.750000 stop=209.500000 lastt=169.500000 A possible explanation of the consistent infusion overlap is if infusion rates are incorrectly noted as ml/min but interpreted as mg/min, assuming propofol 1% --- Gepts et al. --- WARNING: ID=214 DV>200, corrected to dv=2.660000 Probably the decimal place went missing. --- Servin et al., Propofol in alcoholic patients --- WARNING: Individual marked as having WGT= 54 HGT=219 BMI=11.2591 This is probably wrong and HGT will be treated as missing (-1) and BMI set to default (24.2215) WARNING: more that 1 sec overlapping infusions ID=10 time=82.220000 stop=89.496867 lastt=66.530000 ERROR: DV=0 with EVID=0: ID=21 time=0.000000 ERROR: DV=0 with EVID=0: ID=21 time=0.000000 WARNING: more that 1 sec overlapping infusions ID=24 time=71.880000 stop=73.650000 lastt=71.650000 WARNING: more that 1 sec overlapping infusions ID=25 time=13.720000 stop=50.611173 lastt=9.930000 WARNING: more that 1 sec overlapping infusions ID=30 time=0.480000 stop=2.000007 lastt=0.100000 WARNING: more that 1 sec overlapping infusions ID=30 time=2.000000 stop=3.496826 lastt=1.980000 WARNING: more that 1 sec overlapping infusions ID=30 time=4.000000 stop=5.480475 lastt=3.980000 WARNING: more that 1 sec overlapping infusions ID=30 time=6.000000 stop=7.483085 lastt=6.000000 WARNING: more that 1 sec overlapping infusions ID=30 time=8.000000 stop=9.500000 lastt=8.000000 WARNING: more that 1 sec overlapping infusions ID=30 time=10.000000 stop=11.496817 lastt=9.980000 WARNING: more that 1 sec overlapping infusions ID=30 time=11.500000 stop=18.000000 lastt=10.000000 WARNING: more that 1 sec overlapping infusions ID=30 time=23.300000 stop=37.480000 lastt=22.980000 WARNING: more that 1 sec overlapping infusions ID=30 time=38.780000 stop=52.000000 lastt=38.000000 WARNING: more that 1 sec overlapping infusions ID=30 time=52.000000 stop=61.965101 lastt=38.780000 WARNING: more that 1 sec overlapping infusions ID=30 time=61.970000 stop=63.980876 lastt=56.480000 WARNING: more that 1 sec overlapping infusions ID=30 time=63.980000 stop=73.399695 lastt=62.850000 WARNING: more that 1 sec overlapping infusions ID=30 time=74.050000 stop=78.981233 lastt=72.000000 WARNING: more that 1 sec overlapping infusions ID=30 time=78.980000 stop=80.650038 lastt=74.050000 WARNING: more that 1 sec overlapping infusions ID=30 time=81.320000 stop=82.994286 lastt=78.980000 WARNING: more that 1 sec overlapping infusions ID=30 time=83.000000 stop=106.154814 lastt=81.320000 WARNING: more that 1 sec overlapping infusions ID=30 time=106.980000 stop=132.735603 lastt=106.370000 WARNING: more that 1 sec overlapping infusions ID=30 time=134.500000 stop=139.980000 lastt=130.980000 WARNING: more that 1 sec overlapping infusions ID=30 time=139.980000 stop=145.000138 lastt=134.500000 WARNING: more that 1 sec overlapping infusions ID=30 time=145.000000 stop=147.982814 lastt=141.480000 WARNING: more that 1 sec overlapping infusions ID=30 time=149.000000 stop=330.005364 lastt=145.500000 It is not clear what problem may have caused these overlaps of infusions. --- Cortinez et al., Propofol PK in children --- ERROR: DV=0 with EVID=0: ID=62 time=0.000000 ERROR: DV=0 with EVID=0: ID=63 time=0.000000 ERROR: DV=0 with EVID=0: ID=64 time=0.000000 ERROR: DV=0 with EVID=0: ID=65 time=0.000000 ERROR: DV=0 with EVID=0: ID=66 time=0.000000 ERROR: DV=0 with EVID=0: ID=77 time=0.000000 ERROR: DV=0 with EVID=0: ID=78 time=0.000000 ERROR: DV=0 with EVID=0: ID=87 time=0.000000 ERROR: DV=0 with EVID=0: ID=87 time=0.000000 ERROR: DV=0 with EVID=0: ID=87 time=0.000000 ERROR: DV=0 with EVID=0: ID=98 time=0.000000 ERROR: DV=0 with EVID=0: ID=98 time=0.000000 ERROR: DV=0 with EVID=0: ID=98 time=0.000000 ERROR: DV=0 with EVID=0: ID=98 time=0.000000 Observations of value 0 can in some cases cause numerical problems and were ignored. ---- Schnider et al. --- WARNING: Multiple occasions treated as separate individuals (STDY=13 ID=1) WARNING: Multiple occasions treated as separate individuals (STDY=13 ID=2) WARNING: Multiple occasions treated as separate individuals (STDY=13 ID=3) WARNING: Multiple occasions treated as separate individuals (STDY=13 ID=4) WARNING: Multiple occasions treated as separate individuals (STDY=13 ID=5) WARNING: Multiple occasions treated as separate individuals (STDY=13 ID=6) WARNING: Multiple occasions treated as separate individuals (STDY=13 ID=7) WARNING: Multiple occasions treated as separate individuals (STDY=13 ID=8) WARNING: Multiple occasions treated as separate individuals (STDY=13 ID=9) WARNING: Multiple occasions treated as separate individuals (STDY=13 ID=10) WARNING: Multiple occasions treated as separate individuals (STDY=13 ID=11) WARNING: Multiple occasions treated as separate individuals (STDY=13 ID=12) WARNING: Multiple occasions treated as separate individuals (STDY=13 ID=13) WARNING: Multiple occasions treated as separate individuals (STDY=13 ID=14) WARNING: Multiple occasions treated as separate individuals (STDY=13 ID=15) WARNING: Multiple occasions treated as separate individuals (STDY=13 ID=16) WARNING: Multiple occasions treated as separate individuals (STDY=13 ID=17) WARNING: Multiple occasions treated as separate individuals (STDY=13 ID=18) WARNING: Multiple occasions treated as separate individuals (STDY=13 ID=19) WARNING: Multiple occasions treated as separate individuals (STDY=13 ID=20) WARNING: Multiple occasions treated as separate individuals (STDY=13 ID=21) WARNING: Multiple occasions treated as separate individuals (STDY=13 ID=22) WARNING: Multiple occasions treated as separate individuals (STDY=13 ID=23) WARNING: Multiple occasions treated as separate individuals (STDY=13 ID=24) We assumed that inter-occasion variability was the the same as inter-individual variability. Thus we treated multiple equations as if they were separate individuals.