Web Table 1. Values of mean arterial pressure (MAP; mm Hg) at the indicated time points
|
|
Preoperative
visit |
Premedication |
Before
induction |
Before laryngoscopy |
During laryngoscopy |
Before
tracheal intubation |
Two minutes
after tracheal intubation |
Before skin
incision |
Two minutes
after skin incision |
|
Group 1 |
n = 21 93 (11) 93 [70-118] |
n = 21 103 (15) 102 [81-144] |
n = 21 106 (17) 104 [83-157] |
n = 21 75 (14) 75 [59-120] |
n = 21 93 (22) 87 [61-131] |
n = 21 98 (22) 95 [59-139] |
n = 21 87 (13) 87 [67-114] |
n = 21 75 (10) 76 [57-95] |
n = 21 89 (17) 87 [64-131] |
|
Group 2 |
n = 22 95 (13) 93 [73-127] |
n = 22 102 (16) 101 [74-130] |
n = 22 104 (16) 106 [78-131] |
n = 22 80 (19) 85 [42-114] |
n = 22 92 (26) 91 [48-137] |
n = 22 90 (25) 87 [55-156] |
n = 22 88 (21) 92 [41-121] |
n = 22 78 (12) 77 [50-104] |
n = 22 89 (15) 88 [64-119] |
|
Group 3 |
n = 23 91 (15) 89 [73-139] |
n = 23 101 (19) 100 [66-143] |
n = 23 97 (18) 96 [58-143] |
n = 22 75 (15) 72.5 [52-120] |
n = 22 78 (18) 76 [50-120] |
n = 22 86 (25) 79 [53-130] |
n = 23 82 (15) 80 [58-118] |
n = 23 77 (13) 75 [57-109] |
n = 23 86 (12) 84 [62-111] |
|
Group 4 |
n = 20 95 (10) 95 [77-119] |
n = 21 102 (14) 101 [81-146] |
n = 21 102 (14) 101 [81-135] |
n = 20 74 (19) 71 [45-130] |
n = 21 78 ( 23) 76 [46-131] |
n = 21 80 ( 22) 77 [48-143] |
n = 21 80 (16) 76 [51-111] |
n = 21 76 (14) 73 [45-99] |
n = 21 78 (16) 76 [49-110] |
|
Group 5 |
n = 23 93 (11) 93 [75-117] |
n = 22 104 (12) 104 [74-121] |
n = 23 104 (10) 105 [81-124] |
n = 23 76 (16) 71 [57-123] |
n = 23 80 (20) 75 [55-123] |
n = 23 79 (16) 75 [62-122] |
n = 23 80 (17) 77 [56-130] |
n = 22 78 (12) 78 [58-110] |
n = 21 83 (11) 84 [61-107] |
Legend to Web Table 1.
Values are presented as follows: within each cell the top row in the number of
patients, the second row is the Mean (Standard Deviation), the third row is the
Median and the bottom row is the range. There were no significant differences
among the five groups (Repeated measure ANOVA; p = 0.34) and there was no group
versus time interaction (p = 0.34).
|
|
Before sternotomy |
Two minutes after
sternotomy |
Aortic cannulation |
Two minutes before
CPB onset |
Two minutes after
CPB onset |
Ten minutes after
protamine |
Sternal closure |
Skin closure |
Two hours after
arrival in the ICU |
Onset of
spontaneous ventilation |
Five minutes after
tracheal extubation |
Group1 |
n = 21 92 (16) 89 [64-130] |
n = 21 95 (13) 93 [76-124] |
n = 21 86 (15) 85 [61-120] |
n = 21 78 (9) 77 [64-95] |
n = 21 69 (14) 69 [45-101] |
n = 21 77 (12) 77 [54-114] |
n = 21 79 (8) 79 [66-97] |
n = 21 80 (12) 81 [55-98] |
n = 21 79 (15) 76 [51-111] |
n = 21 88 (18) 87 [55-142] |
n = 21 87 (12) 89 [69-111] |
|
Group
2 |
n = 22 92 (12) 93 [71-120] |
n = 22 95 (10) 94 [75-123] |
n = 22 83 (12) 86 [56-104] |
n = 22 78 (14) 74 [61-101] |
n = 21 66 (14) 63 [45-103] |
n = 22 82 (12) 83 [61-102] |
n = 22 81 (10) 81 [63-103] |
n = 21 80 (12) 77 [58-101] |
n = 22 81 (13) 82 [64-120] |
n = 22 88 (13) 88 [62-110] |
n = 22 87 ( 11) 87 [68-116] |
|
Group
3 |
n = 23 90 (13) 89 [72-118] |
n = 23 91 (15) 91 [63-130] |
n = 23 84 (10) 85 [67-106] |
n = 23 76 (11) 75 [59-96] |
n = 23 74 (18) 77 [33-100] |
n = 23 72 (9) 72 [55-96] |
n = 23 74 (8) 72 [60-97] |
n = 23 75 (8) 75 [63-90] |
n = 23 78 (11) 79 [54-100] |
n = 23 86 (12) 86 [61-110] |
n = 23 87 (11) 86 [68-107] |
|
Group
4 |
n = 21 86 (10) 87 [64-110] |
n = 21 90 (11) 94 [69-112] |
n = 21 83 (13) 85 [55-108] |
n = 21 74 (14) 77 [39-97] |
n = 20 68 (20) 74 [38-112] |
n = 21 74 (12) 72 [61-105] |
n = 21 74 (12) 74 [50-106] |
n = 21 76 (10) 72 [67-105] |
n = 21 77 (14) 74 [58-106] |
n = 21 82 (10) 81 [67-98] |
n = 21 82 (12) 81 [63-104] |
|
Group
5 |
n = 22 85 (10) 84 [63-116] |
n = 22 90 (14) 87 [72-124] |
n = 22 88 (17) 85 [67-143] |
n = 22 78 (13) 77 [52-99] |
n = 21 72 (16) 75 [41-95] |
n = 22 74 (12) 73 [53-97] |
n = 22 77 (13) 75 [50-103] |
n = 22 75 (10) 71 [61-97] |
n = 21 80 (14) 79 [63-117] |
n = 22 85 (12) 83 [65-114] |
n = 22 85 (12) 84 [60-112] |
Legend to Web Table 2.
Values are presented as follows: within each cell the top row in the number of
patients, the second row is the Mean (Standard Deviation), the third row is the
Median and the bottom row is the range. There were no significant differences
among the five groups (Repeated measure ANOVA; p = 0.34) and there was no group
versus time interaction (p = 0.34).
Web Table 3. Ratio of mean arterial pressure (MAP)
value at the indicated time point /to the value of MAP measured at the
preoperative visit considered as baseline
|
|
Before induction |
Before laryngoscopy |
During laryngoscopy |
Before
tracheal intubation |
Two minutes
after tracheal intubation |
Before skin
incision |
Two minutes
after skin incision |
Before
sternotomy |
Two minutes
after sternotomy |
|
Group 1 |
n = 21 1.15 ( 0.22) 1.07 [0.9-1.81] |
n = 21 0.82 ( 0.2) 0.79 [0.59-1.38] |
n = 21 1.01 ( 0.26) 0.96 [0.64-1.57] |
n = 21 1.07( 0.31) 1.05 [0.61-1.67] |
n = 21 0.94 ( 0.18) 0.94 [0.65-1.36] |
n = 21 0.81 ( 0.17) 0.77 [0.57-1.21] |
n = 21 0.96 ( 0.24) 0.91 [0.68-1.57] |
n = 21 1 ( 0.23) 0.93 [0.67-1.56] |
n = 21 1.03 ( 0.19) 0.98 [0.75-1.42] |
|
Group 2 |
n = 22 1.1 ( 0.16) 1.07 [0.85-1.47] |
n = 22 0.86 ( 0.21) 0.83 [0.43-1.27] |
n = 22 0.98 ( 0.31) 1.02 [0.4-1.88] |
n = 22 0.97 ( 0.29) 0.97 [0.46-1.64] |
n = 22 0.95 ( 0.27) 0.89 [0.44-1.62] |
n = 22 0.84 ( 0 .14) 0.87 [0.54-1.14] |
n = 22 0.96 ( 0.22) 0.95 [0.53-1.4] |
n = 22 0.98 ( 0.19) 1 [0.61-1.36] |
n = 22 1.02 ( 0.15) 1.04 [0.73-1.32] |
|
Group 3 |
n = 23 1.07 ( 0.17) 1.03 [0.78-1.53] |
n = 22 0.82 ( 0.18) 0.79 [0.52-1.33] |
n = 22 0.88 ( 0.26) 0.83 [0.48-1.43] |
n = 22 0.95 ( 0.28) 0.92 [0.51-1.45] |
n = 23 0.91 ( 0.2) 0.91 [0.51-1.34] |
n = 23 0.85 ( 0.19) 0.82 [0.59-1.26] |
n = 23 0.96 ( 0.19) 0.94 [0.58-1.3] |
n = 23 1.01 ( 0.2) 0.99 [0.61-1.33] |
n = 23 1.01 ( 0.19) 1 [0.68-1.37] |
|
Group 4 |
n = 20 1.07 ( 0.11) 1.05 [0.82-1.3] |
n = 19 0.76 ( 0.2) 0.75 [0.41-1.39] |
n = 20 0.8 ( 0.21) 0.77 [0.45-1.27] |
n = 20 0.82 ( 0.22) 0.83 [0.42-1.53] |
n = 20 0.83 ( 0.15) 0.81 [0.64-1.19] |
n = 20 0.8 ( 0.18) 0.77 [0.48-1.13] |
n = 20 0.82 ( 0.21) 0.76 [0.53-1.27] |
n = 20 0.91 ( 0.17) 0.88 [0.64-1.27] |
n = 20 0.96 ( 0.17) 0.96 [0.61-1.29] |
|
Group 5 |
n = 23 1.13 ( 0.16) 1.1 [0.85-1.49] |
n = 23 0.81 ( 0.11) 0.78 [0.64-1.05] |
n = 23 0.85 ( 0.16) 0.83 [0.62-1.18] |
n = 23 0.85 ( 0.16) 0.85 [0.63-1.3] |
n = 23 0.86 ( 0.17) 0.86 [0.62-1.33] |
n = 22 0.85 ( 0.17) 0.83 [0.58-1.22] |
n = 21 0.91 ( 0.16) 0.89 [0.66-1.19] |
n = 22 0.93 ( 0.18) 0.9 [0.68-1.29] |
n = 22 0.98 ( 0.19) 0.95 [0.71-1.41] |
Legend
to Web Table 3. Values are presented as follows: within each cell the top row
in the number of patients, the second row is the Mean (Standard Deviation), the
third row is the Median and the bottom row is the range. There were no significant
differences among the five groups (Repeated measure ANOVA) and there was no
group versus time interaction.
|
|
Aortic cannulation |
Two minutes
before CPB onset |
Two minutes after CPB onset |
Ten minutes after protamine |
Sternal
closure |
Skin closure |
Two hours
after arrival in the ICU |
Onset of
spontaneous ventilation |
Five minutes
after tracheal extubation |
|
Group 1 |
n = 21 0.93 (0.18) 0.89 [0.71-1.35] |
n = 21 0.84 (0.12) 0.81 [0.6-1.1] |
n = 21 0.74 (0.16) 0.73 [0.48-1.19] |
n = 21 0.83 (0.17) 0.81 [0.59-1.32] |
n = 21 0.85 (0.15) 0.86 [0.56-1.19] |
n = 21 0.87 (0.17) 0.83 [0.55-1.28] |
n = 21 0.85 (0.16) 0.82 [0.48-1.13] |
n = 21 0.96 (0.25) 0.91 [0.61-1.7] |
n = 21 0.93 (0.12) 0.92 [0.78-1.15] |
|
Group 2 |
n = 22 0.89 (0.19) 0.88 [0.56-1.32] |
n = 22 0.84 (0.2) 0.79 [0.48-1.26] |
n = 21 0.71 (0.19) 0.69 [0.38-1.16] |
n = 22 0.88 (0.16) 0.89 [0.51-1.25] |
n = 22 0.86 (0.13) 0.86 [0.65-1.29] |
n = 21 0.85 (0.15) 0.82 [0.6-1.25] |
n = 22 0.87 (0.15) 0.87 [0.64-1.18] |
n = 22 0.93 (0.15) 0.94 [0.62-1.23] |
n = 22 0.93 (0.17) 0.9 [0.68-1.28] |
|
Group 3 |
n = 23 0.94 (0.18) 0.96 [0.52-1.25] |
n = 23 0.86 (0.19) 0.86 [0.5-1.2] |
n = 23 0.82 (0.21) 0.77 [0.38-1.29] |
n = 23 0.8 (0.14) 0.8 [0.49-1.13] |
n = 23 0.82 (0.13) 0.82 [0.47-1.05] |
n = 23 0.83 (0.13) 0.85 [0.45-1.02] |
n = 23 0.87 (0.18) 0.89 [0.57-1.28] |
n = 23 0.95 (0.17) 0.92 [0.66-1.31] |
n = 23 0.96 (0.13) 0.93 [0.72-1.23] |
|
Group 4 |
n = 20 0.87 (0.16) 0.9 [0.63-1.16] |
n = 20 0.78 (0.17) 0.83 [0.45-1.12] |
n = 19 0.72 (0.22) 0.75 [0.32-1.08] |
n = 20 0.77 (0.13) 0.75 [0.59-1.09] |
n = 20 0.78 (0.15) 0.77 [0.58-1.07] |
n = 20 0.8 (0.10) 0.8 [0.62-1.01] |
n = 20 0.82 (0.17) 0.84 [0.54-1.12] |
n = 20 0.86 (0.12) 0.85 [0.59-1.12] |
n = 20 0.86 (0.12) 0.85 [0.64-1.16] |
|
Group 5 |
n = 22 0.95 (0.2) 0.88 [0.7-1.39] |
n = 22 0.85 (0.18) 0.81 [0.5-1.2] |
n = 21 0.79 (0.2) 0.75 [0.41-1.13] |
n = 22 0.81 (0.18) 0.81 [0.51-1.3] |
n = 22 0.84 (0.22) 0.81 [0.54-1.29] |
n = 22 0.83 (0.18) 0.84 [0.61-1.24] |
n = 21 0.87 (0.17) 0.88 [0.57-1.17] |
n = 22 0.92 (0.16) 0.88 [0.7-1.37] |
n = 22 0.93 (0.21) 0.88 [0.65-1.34] |
Legend to Web Table 4.
Values are presented as follows: within each cell the top row in the number of
patients, the second row is the Mean (Standard Deviation), the third row is the
Median and the bottom row is the range. There were no significant differences
among the five groups (Repeated measure ANOVA) and there was no group versus
time interaction
Web Table 5. Values of heart rate (bpm) at the indicated
time-points
|
|
Preoperative visit |
Premedication |
Before induction |
Before laryngoscopy |
Laryngoscopy |
Before intubation |
Two minutes after
intubation |
Before skin
incision |
Two minutes after skin incision |
Group 1 |
n = 21 61 (9) 60 [39-80] |
n = 21 57 (8) 57 [40-74] |
n = 21 57 (8) 57 [42-72] |
n = 21 57 (9) 57 [40-75] |
n = 21 60 (10) 60 [43-79] |
n = 21 64 (11) 63 [46-88] |
n = 21 64 (11) 65 [47-88] |
n = 21 54 (8) 54 [37-75] |
n = 21 56 (10) 54 [37-80] |
Group 2 |
n = 22 62 (9) 61 [43-80] |
n = 22 58 (11) 56 [43-101] |
n = 22 58 (9) 58 [43-91] |
n = 22 57 (12) 57 [44-93] |
n = 22 58 (12) 57.5 [44-88] |
n = 22 61 (13) 59 [42-94] |
n = 22 63 (11) 61.5 [45-86] |
n = 22 55 (9) 53.5 [40-75] |
n = 22 56 (10) 56 [40-77] |
Group 3 |
n = 23 64 (9) 60 [49-80] |
n = 23 60 (9) 60 [48-74] |
n = 23 62 (10) 62 [46-82] |
n = 22 58 (9) 57.5 [42-78] |
n = 22 58 (9) 61 [39-77] |
n = 23 61 (9) 63 [48-81] |
n = 23 64 (10) 65 [48-90] |
n = 23 57 (8) 58 [42-75] |
n = 23 62 (12) 60 [44-90] |
Group 4 |
n = 20 62 (10) 61 [46-86] |
n = 21 59 (8) 59 [46-77] |
n = 21 59 (8) 60 [47-77] |
n = 19 57 (10) 54 [45-86] |
n = 20 57(10) 54 [45-89] |
n = 21 58 (10) 56 [45-88] |
n = 21 60 (9) 59 [48-84] |
n = 21 56 (10) 55 [42-80] |
n = 21 56 (8) 56 [42-72] |
Group 5 |
n = 22 63 (8) 65 [48-77] |
n = 23 63 (12) 62 [44-101] |
n = 23 63 (11) 61 [44-103] |
n = 23 62 (12) 63 [44-94] |
n = 23 63 (15) 63 [44-107] |
n = 23 62 (12) 64 [42-89] |
n = 23 65 (12) 66 [42-95] |
n = 22 58 (11) 56 [42-84] |
n = 22 58 (11) 56 [45-84] |
Legend to Web Table 5. Values are presented as
follows: within each cell the top row in the number of patients, the second row
is the Mean (Standard Deviation), the third row is the Median and the bottom
row is the range. There were no significant differences among the five groups
(Repeated measure ANOVA; p = 0.91) and there was no group versus time
interaction (p = 0.79).
Web Table 6. Values
of heart rate (bpm) at the indicated time-points
|
|
Before sternotomy |
Two minutes after
sternotomy |
Aortic cannulation |
Two minutes before
CPB onset |
Ten minutes after
protamine |
Sternal closure |
Skin closure |
Two hours after
arrival in the ICU |
Onset of spontaneous ventilation |
Five minutes after tracheal extubation |
Group 1 |
n = 21 57 (11) 56 [37-87] |
n = 21 62 (12) 61 [38-91] |
n = 21 66 (15) 67 [40-98] |
n = 21 69 (13) 74 [42-90] |
n = 21 75 (11) 75 [42-98] |
n = 21 76 (12) 76 [43-103] |
n = 21 76 (11) 76 [42-92] |
n = 21 75 (14) 78 [40-100] |
n = 21 81 (10) 80 [69-114] |
n = 21 84 (13) 86 [49-105] |
Group 2 |
n = 22 58 (11) 57 [38-75] |
n = 22 60 (12) 59 [43-85] |
n = 22 62 (11) 59 [47-92] |
n = 22 69 (11) 69 [ 47-85 ] |
n = 22 76 (8) 78 [55-91] |
n = 22 76 (11) 76 [51-98] |
n = 22 74 (9) 75 [56-100] |
n = 22 74 (10) 75 [56-95] |
n = 22 86 (15) 85 [63-120] |
n = 22 85 (12) 82 [68-110] |
Group 3 |
n = 23 58 (10) 60 [43-79] |
n = 23 63 (11) 62 [45-87] |
n = 23 65 (12) 63 [47-92] |
n = 23 73 (16) 73 [51-115] |
n = 23 77 (9) 74 [64-98] |
n = 23 77 (9) 76 [62-97] |
n = 23 77 (8) 77 [60-95] |
n = 23 79 (13) 78 [60-108] |
n = 23 86 (10) 86 [68-110] |
n = 23 88 (10) 88 [71-120] |
Group 4 |
n = 21 58 (11) 58 [42-80] |
n = 21 58 (9) 58 [45-76] |
n = 21 58 (11) 54 [46-90] |
n = 21 64 (9) 64 [50-86] |
n = 21 77 (12) 75 [51-110] |
n = 21 76 (12) 76 [48-99] |
n = 21 76 (13) 77 [50-95] |
n = 21 76 (14) 74 [47-101] |
n = 21 83 (12) 83 [62-110] |
n = 21 84 (13) 84 [55-110] |
Group 5 |
n = 22 61 (13) 58 [45-95] |
n = 22 61 (12) 64 [42-86] |
n = 22 65 (14) 63 [44-95] |
n = 22 75 (16) 71 [52-105] |
n = 22 80 (12) 80 [48-112] |
n = 22 81 (11) 80 [60-114] |
n = 21 79 (12) 77 [56-113] |
n = 22 81 (16) 80 [52-125] |
n = 22 87 (16) 86 [60-120] |
n = 22 88 (15) 85 [63-113] |
Legend to Web Table 6. Values are presented as
follows: within each cell the top row in the number of patients, the second row
is the Mean (Standard Deviation), the third row is the Median and the bottom
row is the range. There were no significant differences among the five groups
(Repeated measure ANOVA; p = 0.91) and there was no group versus time
interaction (p = 0.79).
Web Table 7. Ratio of heart rate (HR) measured
at the indicated time point/ value of HR measured at the preoperative visit
considered as baseline
|
|
Before induction |
Before laryngoscopy |
During laryngoscopy |
Before
tracheal intubation |
Two minutes
after tracheal intubation |
Before skin incision |
Two minutes
after skin incision |
Before
sternotomy |
Two minutes
after sternotomy |
|
Group 1 |
n = 21 0.96 (0.18) 0.97 [0.65-1.38] |
n = 21 0.96 (0.18) 0.98 [0.6-1.46] |
n = 21 1 (0.2) 1 [0.69-1.58] |
n = 21 1.08 (0.25) 1.07 [0.71-1.76] |
n = 21 1.08 (0.23) 1.08 [0.68-1.76] |
n = 21 0.89 (0.14) 0.91 [0.68-1.12] |
n = 21 0.94 (0.18) 0.88 [0.71-1.24] |
n = 21 0.95 (0.18) 1.02 [0.65-1.28] |
n = 21 1.04 (0.22) 1.05 [0.73-1.53] |
|
Group 2 |
n = 22 0.95 (0.16) 0.96 [0.71-1.4] |
n = 22 0.92 (0.18) 0.92 [0.64-1.43] |
n = 22 0.94 (0.18) 0.93 [0.65-1.47] |
n = 22 0.98 (0.18) 0.99 [0.72-1.45] |
n = 22 1.02 (0.16) 1.02 [0.69-1.38] |
n = 22 0.89 (0 .18) 0.89 [0.58-1.2] |
n = 22 0.92 (0.2) 0.92 [0.56-1.28] |
n = 22 0.94 (0.2) 0.94 [0.6-1.33] |
n = 22 0.98 (0.25) 0.96 [0.56-1.42] |
|
Group 3 |
n = 23 0.97 (0.13) 0.97 [0.73-1.25] |
n = 22 0.92 (0.13) 0.92 [0.61-1.15] |
n = 22 0.93 (0.13) 0.88 [0.66-1.2] |
n = 23 0.97 ( 0.17) 0.95 [0.63-1.42] |
n = 23 1.01 (0.17) 0.98 [0.63-1.4] |
n = 23 0.89 (0.14) 0.89 [0.59-1.19] |
n = 23 0.97 (0.17) 0.96 [0.59-1.33] |
n = 23 0.92 (0.15) 0.91 [0.58-1.21] |
n = 23 0.98 (0.15) 0.98 [0.62-1.23] |
|
Group 4 |
n = 20 0.97 (0.16) 0.94 [0.69-1.3] |
n = 18 0.93 (0.17) 0.94 [0.63-1.32] |
n = 19 0.92 (0.18) 0.9 [0.63-1.37] |
n = 20 0.93 (0.17) 0.95 [0.67-1.35] |
n = 20 0.98 (0.19) 1 [0.67-1.43] |
n = 20 0.91 (0.17) 0.93 [0.66-1.27] |
n = 20 0.91 (0.16) 0.92 [0.66-1.24] |
n = 20 0.96 (0.21) 0.93 [0.66-1.33] |
n = 20 0.94 (0.16) 0.93 [0.67-1.25] |
|
Group 5 |
n = 22 0.98 (0.14) 0.96 [0.76-1.47] |
n = 22 0.97 (0.17) 0.94 [0.68-1.45] |
n = 22 0.99 (0.21) 0.96 [0.63-1.53] |
n = 22 0.97 (0.17) 0.97 [0.63-1.48] |
n = 22 1.01 (0.17) 1.04 [0.72-1.39] |
n = 21 0.91 (0.10) 0.92 [0.64-1.11] |
n = 21 0.91 (0.11) 0.9 [0.6-1.14] |
n = 21 0.94 (0.12) 0.94 [0.7-1.25] |
n = 21 0.95 (0.15) 0.94 [0.72-1.43] |
Legend to Web Table 7. Values are presented as
follows: within each cell the top row in the number of patients, the second row
is the Mean (Standard Deviation), the third row is the Median and the bottom
row is the range. There were no significant differences among the five groups
(Repeated measure ANOVA) and there was no group versus time interaction .
|
|
Aortic cannulation |
Two minutes
before CPB onset |
Ten minutes after protamine |
Sternal closure |
Skin closure |
Two hours
after arrival in the ICU |
Onset of
spontaneous ventilation |
Five minutes
after tracheal intubation |
|
Group 1 |
n = 21 1.1 (0.28) 1.06 [0.67-1.96] |
n = 21 1.15 (0.24) 1.11 [0.81-1.67] |
n = 21 1.25 (0.2) 1.25 [0.84-1.78] |
n = 21 1.27 (0.18) 1.25 [1.05-1.8] |
n = 21 1.26 (0.18) 1.25 [0.97-1.68] |
n = 21 1.25 (0.21) 1.26 [0.73-1.7] |
n = 21 1.35 (0.23) 1.32 [1.08-1.9] |
n = 21 1.4 (0.23) 1.35 [1.07-2] |
|
Group 2 |
n = 22 1.01 (0.24) 0.99 [0.65-1.67] |
n = 22 1.12 (0.25) 1.11 [0.78-1.86] |
n = 22 1.24 (0.23) 1.23 [0.84-1.79] |
n = 22 1.25 (0.23) 1.3 [0.78-1.72] |
n = 22 1.2 (0.23) 1.24 [0.79-1.72] |
n = 22 1.21 (0.22) 1.24 [0.7-1.58] |
n = 22 1.39 (0.28) 1.43 [0.79-2] |
n = 22 1.39 (0.25) 1.45 [0.94-1.73] |
|
Group 3 |
n = 23 1.03 (0.19) 0.98 [0.68-1.41] |
n = 23 1.15 (0.26) 1.09 [0.78-2.09] |
n = 23 1.22 (0.16) 1.24 [0.82-1.57] |
n = 23 1.21 (0.17) 1.23 [0.85-1.63] |
n = 23 1.22 (0.15) 1.23 [0.87-1.55] |
n = 23 1.26 (0.31) 1.2 [0.8-2.02] |
n = 23 1.37 (0.26) 1.31 [1.08-2.08] |
n = 23 1.41 (0.28) 1.32 [1.06-2.26] |
|
Group 4 |
n = 20 0.94 (0.18) 0.93 [0.64-1.24] |
n = 20 1.04 (0.18) 1.05 [0.8-1.45] |
n = 20 1.26 (0.23) 1.25 [0.85-1.76] |
n = 20 1.25 (0.23) 1.22 [0.8-1.75] |
n = 20 1.24 (0.24) 1.24 [0.83-1.76] |
n = 20 1.25 (0.28) 1.21 [0.88-1.84] |
n = 20 1.36 (0.29) 1.29 [0.96-1.78] |
n = 20 1.36 (0.28) 1.34 [0.94-1.8] |
|
Group 5 |
n = 21 1.01 (0.15) 1.02 [0.77-1.3] |
n = 21 1.16 (0.26) 1.13 [0.81-2.13] |
n = 21 1.27 (0.2) 1.26 [0.92-1.69] |
n = 21 1.29 (0.2) 1.24 [0.92-1.63] |
n = 20 1.27 (0.2) 1.25 [0.89-1.69] |
n = 21 1.28 (0.22) 1.26 [0.91-1.79] |
n = 21 1.37 (0.26) 1.28 [1.11-2.27] |
n = 21 1.39 (0.23) 1.35 [1.14-2.23] |
Legend to Web Table 8. Values are presented as
follows: within each cell the top row in the number of patients, the second row
is the Mean (Standard Deviation), the third row is the Median and the bottom
row is the range. There were no significant differences among the five groups
(Repeated measure ANOVA) and there was no group versus time interaction .
Web Table 9. Episodes of arterial hypotension,
hypertension, bradycardia and tachycardia that occurred in the operation room.
|
|
Group 1 n = 21 |
Group 2 n = 22 |
Group 3 n = 23 |
Group 4 n = 21 |
Group 5 n = 23 |
Total n = 110 |
P value |
|
|
|
Hypotension |
Number
of patients (%) |
11 (52 %) |
14 (64 %) |
16 (70 %) |
18 (86 %) |
16 (70 %) |
75 (68 %) |
0.22 0.74 |
|
|
Number
of episodes per patient |
3 (3) 2 [1-10] |
2.8 (1.4) 3 [1-5] |
3.1 (2.2) 2.5 [1-8] |
2.4 (1.9) 2 [1-9] |
2.4 (1.5) 2 [1-6] |
2.7 (2) 2 [1-10] |
|
||
|
Hypertension |
Number
of patients (%) |
14 (67 %) |
16 (73 %) |
14 (61 %) |
8 (38 %) |
11 (48 %) |
63 (57 %) |
0.14 0.51 |
|
|
Number
of episodes per patient |
2.9 (2) 2 [1-8] |
2.1 (1.6) 2 [1-7] |
1.8 (0.8) 2 [1-3] |
2.3 (1.4) 2 [1-4] |
2 (0.9) 2 [1-3] |
2.2 (1.5) 2 [1-8] |
|
||
|
Bradycardia |
Number
of patients (%) |
2 (10 %) |
2 (9 %) |
4 (17 %) |
1 (5 %) |
3 (13 %) |
12 (11 %) |
0.79 0.35 |
|
|
Number
of episodes per patient |
2 (1.4) 2 [1-3] |
1.5 (0.7) 1.5 [1-2] |
1 (0) |
1 (0) |
1 (0) |
1.3 (0.6) 1 [1-3] |
|
||
|
Tachycardia |
Number
of patients (%) |
1 (5 %) |
0 |
1 (4 %) |
4 (19 %) |
0 |
6 (5 %) |
0.03 0.33 |
|
|
Number
of episodes per patient |
2 (0) |
|
1 (0) |
1.3 (0.5) 1 [1-2] |
|
1.3 (0.5) 1 [1-2] |
|||
Legend
to Web Table 9. The numbers of episodes per patient are presented as follows.
The top row is the mean (Standard Deviation)
number of episodes; the middle row is the median and the lower row is
the range. If only one row is present within a cell it represents the mean
(Standard Deviation). There were no significant differences among the five
groups for any hemodynamic event. A similar analysis was performed from
induction of anesthesia to skin incision and there were no statistically
significant differences among the five groups.
Web Table 10. Cardiovascular
drugs requirement during anesthesia
|
Cardiovascular drugs |
Group 1 n = 21 |
Group 2 n = 22 |
Group 3 n = 23 |
Group 4 n = 21 |
Group 5 n = 23 |
P value |
|
|
Ephedrine |
Number of patients
(%) |
10 (48 %) |
12 (54 %) |
12 (52 %) |
13 (62 %) |
14 (61 %) |
0.84 |
|
Number of bolus//patient |
1.1 (1.9) 0 [0-7] |
1.2 (1.3) 1 [0-4] |
1.2 (1.7) 1 [0-6] |
1.2 (1.3) 1 [0-4] |
1.5 (1.8) 1 [0-7] |
||
|
Cumulative dose
(mg) |
13.9 (8.9) 12 [3-30] |
11.8 (7.9) 12 [3-27] |
12.7 (8.6) 10.5 [3-30] |
9.69 (4.8) 9 [3-18] |
18 (14) 13.5 [3-45] |
0.64 |
|
|
Phenylephrine |
Number of patients
(%) |
3 (14 %) |
4 (18 %) |
6 (26 %) |
6 (29 %) |
5 (22 %) |
0.68 |
|
Number of bolus//patient |
0.3 (1.1) 0 [0-5] |
0.5 (1.4) 0 [0-5] |
0.8 (1.9) 0 [0-8] |
0.9 (2.1) 0 [0-9] |
0.2 (0.4) 0 [0-1] |
||
|
Cumulative dose
(µg) |
233 (230) 100 [100-500] |
391 (258) 475 [15-600] |
590 (387) 625 [144-1000] |
408 (453) 275 [50-1300] |
103 (96) 50 [16-250] |
0.17 |
|
|
Nicardipine |
Number of patients
(%) |
14 (67 %) |
16 (73 %) |
14 (61 %) |
8 (38 %) |
11 (48 %) |
0.15 |
|
Number of bolus//patient |
2 (2.2) 2 [0-8] |
1.5 (1.7) 1 [0-7] |
1.1 (1.1) 1 [0-3] |
0.9 (1.4) 0 [0-4] |
1 (1.2) 0 [0-3] |
||
|
Cumulative dose
(mg) |
3.86 (4.4) 2.25 [0.5-15.5] |
3.21 (5.8) 1.5 [0.5-24.5] |
1.21 (0.7) 1 [0.5-2.5] |
1.56 (1.1) 1.75 [0.5-3.5] |
3.27 (5.8) 1 [0.5-20.5] |
0.46 |
|
|
Atropine |
Number of patients
(%) |
2 (10 %) |
2 (9 %) |
4 (17 %) |
0 |
2 (23 %) |
0.41 |
|
Number of bolus//patient |
0.1 (0.3) 0 [0-1] |
0.1 (0.5) 0 [0-2] |
0.2 (0.4) 0 [0-1] |
|
0.1 (0.3) 0 [0-1] |
||
|
Cumulative
dose(mg) |
1 (0) |
1.25 (1.1) 1.25 [0.5-2] |
0.75 (0.3) 0.75 [0.5-1] |
|
1.25 (1.1) 1.25 [0.5-2] |
0.83 |
|
|
Esmolol |
Number of patients
(%) |
1 (5 %) |
0 |
0 |
4 (19 %) |
0 |
NS |
|
Number of bolus//patient |
0.1 (0.4) 0 [0-2] |
|
|
0.2 (0.5) 0 [0-2] |
|
||
|
Cumulative dose
(mg) |
40 (0) |
|
|
26.2 (7.5) 25 [20-35] |
|
0.14 |
|
Legend
to Web Table 10. Values are
presented as follows: within each cell the top row is the Mean (Standard
deviation), the second row is the median value and the bottom row is the range.
If only one row is present within a cell it represents the mean (Standard
Deviation). There were no significant differences among the five groups for any
of the cardiovascular drugs (percentage of patients, number of bolus injections
or cumulative doses).