0WARNING: PARAMETER LPAR2 NOT SET CORRECTLY 0WARNING: PARAMETER LPAR3 NOT SET CORRECTLY 0WARNING: PARAMETER MTHVR NOT SET CORRECTLY 1NONLINEAR MIXED EFFECTS MODEL PROGRAM (NONMEM) DOUBLE PRECISION NONMEM VERSION V LEVEL 1.0 DEVELOPED AND PROGRAMMED BY STUART BEAL AND LEWIS SHEINER PROBLEM NO.: 1 Minto Model 0DATA CHECKOUT RUN: NO DATA SET LOCATED ON UNIT NO.: 2 THIS UNIT TO BE REWOUND: NO NO. OF DATA RECS IN DATA SET: 95 NO. OF DATA ITEMS IN DATA SET: 4 ID DATA ITEM IS DATA ITEM NO.: 1 DEP VARIABLE IS DATA ITEM NO.: 4 0LABELS FOR DATA ITEMS: ID REMI PROP INT 0FORMAT FOR DATA: (4E6.0) TOT. NO. OF OBS RECS: 95 TOT. NO. OF INDIVIDUALS: 20 0LENGTH OF THETA: 7 0OMEGA HAS BLOCK FORM: 1 0 2 0 0 3 0 0 0 4 0 0 0 0 5 0 0 0 0 0 6 0 0 0 0 0 0 7 0INITIAL ESTIMATE OF THETA: LOWER BOUND INITIAL EST UPPER BOUND .5000E+01 .2000E+02 .3000E+02 .1000E+01 .1620E+01 .4000E+01 .0000E+00 .0000E+00 .0000E+00 .1000E+01 .3150E+01 .2000E+02 .0000E+00 .2560E+01 .4000E+01 .0000E+00 .1350E+01 .4000E+01 .1000E+00 .5090E+01 .1000E+02 0INITIAL ESTIMATE OF OMEGA: BLOCK SET NO. BLOCK FIXED 1 NO .2600E+00 2 NO .2250E+00 3 YES .0000E+00 4 YES .0000E+00 5 NO .1190E-02 6 NO .3430E-03 7 YES .0000E+00 0ESTIMATION STEP OMITTED: NO CONDITIONAL ESTIMATES USED: YES CENTERED ETA: NO EPS-ETA INTERACTION: NO LAPLACIAN OBJ. FUNC.: YES NUMERICAL 2ND DERIVATIVES: NO PRED F SET TO A LIKELIHOOD: YES NO. OF FUNCT. EVALS. ALLOWED: 2000 NO. OF SIG. FIGURES REQUIRED: 6 INTERMEDIATE PRINTOUT: YES ESTIMATE OUTPUT TO MSF: NO ABORT WITH PRED EXIT CODE 1: NO 0COVARIANCE STEP OMITTED: NO EIGENVLS. PRINTED: NO SPECIAL COMPUTATION: NO COMPRESSED FORMAT: NO 1 MONITORING OF SEARCH: 0ITERATION NO.: 0 OBJECTIVE VALUE: .9257E+02 NO. OF FUNC. EVALS.: 8 CUMULATIVE NO. OF FUNC. EVALS.: 8 PARAMETER: .1000E+00 .1000E+00 .1000E+00 .1000E+00 .1000E+00 .1000E+00 .1000E+00 .1000E+00 .1000E+00 .1000E+00 GRADIENT: .2285E+04 -.2192E+04 -.1705E+04 .1782E+04 .8726E+03 -.8935E+03 .1124E+04 -.2088E+04 -.1898E+02 .2902E+00 0ITERATION NO.: 5 OBJECTIVE VALUE: .9130E+02 NO. OF FUNC. EVALS.:12 CUMULATIVE NO. OF FUNC. EVALS.: 79 PARAMETER: .9818E-01 .9667E-01 .9849E-01 .9914E-01 .9561E-01 .1060E+00 .9666E-01 .9666E-01 .9927E-01 .1000E+00 GRADIENT: -.5920E+04 .5346E+04 .4466E+04 -.3274E+04 -.2070E+04 .2261E+04 -.2916E+04 .5846E+04 .3824E+02 -.6174E+00 0ITERATION NO.: 10 OBJECTIVE VALUE: .9097E+02 NO. OF FUNC. EVALS.:14 CUMULATIVE NO. OF FUNC. EVALS.: 148 PARAMETER: .9726E-01 .9656E-01 .9926E-01 .9912E-01 .9567E-01 .1061E+00 .9786E-01 .9574E-01 .9916E-01 .9999E-01 GRADIENT: -.1415E+04 .1554E+04 .1117E+04 -.5739E+04 -.2716E+03 -.6914E+02 -.1171E+04 .9425E+03 .6682E+02 -.1020E+00 0ITERATION NO.: 15 OBJECTIVE VALUE: .9013E+02 NO. OF FUNC. EVALS.:10 CUMULATIVE NO. OF FUNC. EVALS.: 197 PARAMETER: .9640E-01 .9766E-01 .1017E+00 .9935E-01 .9256E-01 .1009E+00 .1038E+00 .9579E-01 .1052E+00 .1016E+00 GRADIENT: .4579E+03 .5989E+03 -.3759E+02 -.1374E+05 .8213E+03 -.2218E+04 -.1205E+04 -.1736E+04 .1585E+03 .1788E+00 0ITERATION NO.: 20 OBJECTIVE VALUE: .8892E+02 NO. OF FUNC. EVALS.:34 CUMULATIVE NO. OF FUNC. EVALS.: 273 PARAMETER: .9666E-01 .9908E-01 .1011E+00 .9975E-01 .9394E-01 .9977E-01 .1041E+00 .9639E-01 .1136E+00 .1098E+00 GRADIENT: -.4198E+06 .3837E+06 .3059E+06 -.6941E+05 -.1471E+06 .1933E+06 -.1666E+06 .4153E+06 .8575E+03 -.4460E+02 0ITERATION NO.: 25 OBJECTIVE VALUE: .8853E+02 NO. OF FUNC. EVALS.:15 CUMULATIVE NO. OF FUNC. EVALS.: 353 PARAMETER: .9681E-01 .9843E-01 .1010E+00 .9959E-01 .9364E-01 .1012E+00 .1029E+00 .9595E-01 .1104E+00 .1188E+00 GRADIENT: .3170E+06 -.2868E+06 -.2340E+06 .1564E+05 .1135E+06 -.1517E+06 .1247E+06 -.3234E+06 -.1929E+03 .3797E+02 0ITERATION NO.: 30 OBJECTIVE VALUE: .8814E+02 NO. OF FUNC. EVALS.:15 CUMULATIVE NO. OF FUNC. EVALS.: 434 PARAMETER: .9701E-01 .9824E-01 .1007E+00 .9957E-01 .9389E-01 .1023E+00 .1015E+00 .9555E-01 .1069E+00 .1067E+00 GRADIENT: -.5897E+06 .5394E+06 .4379E+06 -.1813E+06 -.2058E+06 .2564E+06 -.2534E+06 .5944E+06 .2184E+04 -.6396E+02 0ITERATION NO.: 35 OBJECTIVE VALUE: .8725E+02 NO. OF FUNC. EVALS.:18 CUMULATIVE NO. OF FUNC. EVALS.: 523 PARAMETER: .9684E-01 .9830E-01 .1010E+00 .9963E-01 .9447E-01 .1021E+00 .1015E+00 .9544E-01 .1044E+00 .1091E+00 GRADIENT: .2717E+07 -.2507E+07 -.2090E+07 .4514E+06 .1065E+07 -.1332E+07 .1235E+07 -.3035E+07 -.5365E+04 .3430E+03 0ITERATION NO.: 40 OBJECTIVE VALUE: .8655E+02 NO. OF FUNC. EVALS.: 9 CUMULATIVE NO. OF FUNC. EVALS.: 621 PARAMETER: .9686E-01 .9829E-01 .1010E+00 .9962E-01 .9440E-01 .1021E+00 .1015E+00 .9541E-01 .1036E+00 .1074E+00 GRADIENT: .4754E+07 .3055E+07 .2097E+07 .1464E+06 .1297E+07 .6292E+06 .6320E+06 -.1691E+07 .1654E+04 .1872E+03 0ITERATION NO.: 45 OBJECTIVE VALUE: .8376E+02 NO. OF FUNC. EVALS.:15 CUMULATIVE NO. OF FUNC. EVALS.: 717 PARAMETER: .9686E-01 .9829E-01 .1010E+00 .9962E-01 .9440E-01 .1021E+00 .1015E+00 .9541E-01 .1036E+00 .1074E+00 GRADIENT: -.1441E+05 .2450E+04 .1549E+05 .6093E+06 -.4043E+05 .7427E+05 .2099E+05 .3925E+05 .1474E+06 -.1175E+04 0MINIMIZATION SUCCESSFUL NO. OF FUNCTION EVALUATIONS USED: 717 NO. OF SIG. DIGITS IN FINAL EST.: 6.3 ETABAR IS THE ARITHMETIC MEAN OF THE ETA-ESTIMATES, AND THE P-VALUE IS GIVEN FOR THE NULL HYPOTHESIS THAT THE TRUE MEAN IS 0. ETABAR: -.28E-01 .17E-01 .00E+00 .00E+00 -.48E-03 .80E-04 .00E+00 P VAL.: .70E+00 .76E+00 .10E+01 .10E+01 .41E+00 .21E+00 .10E+01 0S MATRIX ALGORITHMICALLY SINGULAR 0T MATRIX SET EQUAL TO RS*R, WHERE S* IS A PSEUDO INVERSE OF S 1 ************************************************************************************************************************ ******************** ******************** ******************** MINIMUM VALUE OF OBJECTIVE FUNCTION ******************** ******************** ******************** ************************************************************************************************************************ ************************************************** 83.762 ************************************************** 1 ************************************************************************************************************************ ******************** ******************** ******************** FINAL PARAMETER ESTIMATE ******************** ******************** ******************** ************************************************************************************************************************ THETA - VECTOR OF FIXED EFFECTS PARAMETERS ********* TH 1 TH 2 TH 3 TH 4 TH 5 TH 6 TH 7 1.93E+01 1.60E+00 0.00E+00 3.19E+00 2.55E+00 1.22E+00 5.25E+00 OMEGA - COV MATRIX FOR RANDOM EFFECTS - ETAS ******** ETA1 ETA2 ETA3 ETA4 ETA5 ETA6 ETA7 ETA1 + 2.68E-01 ETA2 + 0.00E+00 2.05E-01 ETA3 + 0.00E+00 0.00E+00 0.00E+00 ETA4 + 0.00E+00 0.00E+00 0.00E+00 0.00E+00 ETA5 + 0.00E+00 0.00E+00 0.00E+00 0.00E+00 1.28E-03 ETA6 + 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 3.96E-04 ETA7 + 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 1 ************************************************************************************************************************ ******************** ******************** ******************** STANDARD ERROR OF ESTIMATE ******************** ******************** ******************** ************************************************************************************************************************ THETA - VECTOR OF FIXED EFFECTS PARAMETERS ********* TH 1 TH 2 TH 3 TH 4 TH 5 TH 6 TH 7 2.25E-07 2.63E-09 ......... 9.46E-09 1.93E-07 3.88E-08 7.20E-09 OMEGA - COV MATRIX FOR RANDOM EFFECTS - ETAS ******** ETA1 ETA2 ETA3 ETA4 ETA5 ETA6 ETA7 ETA1 + 2.65E-09 ETA2 + ......... 4.42E-09 ETA3 + ......... ......... ......... ETA4 + ......... ......... ......... ......... ETA5 + ......... ......... ......... ......... 1.22E-08 ETA6 + ......... ......... ......... ......... ......... 6.51E-08 ETA7 + ......... ......... ......... ......... ......... ......... ......... 1 ************************************************************************************************************************ ******************** ******************** ******************** COVARIANCE MATRIX OF ESTIMATE ******************** ******************** ******************** ************************************************************************************************************************ TH 1 TH 2 TH 3 TH 4 TH 5 TH 6 TH 7 OM11 OM12 OM13 OM14 OM15 OM16 OM17 OM22 OM23 OM24 OM25 OM26 OM27 OM33 OM34 OM35 OM36 OM37 OM44 OM45 OM46 OM47 OM55 OM56 OM57 OM66 OM67 OM77 TH 1 + 5.08E-14 TH 2 + -5.92E-16 6.90E-18 TH 3 + ......... ......... ......... TH 4 + -2.13E-15 2.48E-17 ......... 8.94E-17 TH 5 + -4.35E-14 5.07E-16 ......... 1.82E-15 3.72E-14 TH 6 + 8.73E-15 -1.02E-16 ......... -3.67E-16 -7.48E-15 1.50E-15 TH 7 + -1.62E-15 1.89E-17 ......... 6.81E-17 1.39E-15 -2.79E-16 5.18E-17 OM11 + -5.96E-16 6.95E-18 ......... 2.50E-17 5.10E-16 -1.03E-16 1.90E-17 7.00E-18 OM12 + ......... ......... ......... ......... ......... ......... ......... ......... ......... OM13 + ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... OM14 + ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... OM15 + ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... OM16 + ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... OM17 + ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... OM22 + 9.97E-16 -1.16E-17 ......... -4.18E-17 -8.53E-16 1.71E-16 -3.18E-17 -1.17E-17 ......... ......... ......... ......... ......... ......... 1.96E-17 OM23 + ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... OM24 + ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... OM25 + ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... OM26 + ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... 1 TH 1 TH 2 TH 3 TH 4 TH 5 TH 6 TH 7 OM11 OM12 OM13 OM14 OM15 OM16 OM17 OM22 OM23 OM24 OM25 OM26 OM27 OM33 OM34 OM35 OM36 OM37 OM44 OM45 OM46 OM47 OM55 OM56 OM57 OM66 OM67 OM77 OM27 + ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... OM33 + ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... OM34 + ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... OM35 + ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... OM36 + ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... OM37 + ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... OM44 + ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... OM45 + ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... OM46 + ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... OM47 + ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... OM55 + -2.74E-15 3.19E-17 ......... 1.15E-16 2.34E-15 -4.71E-16 8.75E-17 3.21E-17 ......... ......... ......... ......... ......... ......... -5.37E-17 ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... 1.48E-16 OM56 + ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... OM57 + ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... OM66 + -1.47E-14 1.71E-16 ......... 6.15E-16 1.26E-14 -2.52E-15 4.68E-16 1.72E-16 ......... ......... ......... ......... ......... ......... -2.88E-16 ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... 7.91E-16 ......... ......... 4.23E-15 1 TH 1 TH 2 TH 3 TH 4 TH 5 TH 6 TH 7 OM11 OM12 OM13 OM14 OM15 OM16 OM17 OM22 OM23 OM24 OM25 OM26 OM27 OM33 OM34 OM35 OM36 OM37 OM44 OM45 OM46 OM47 OM55 OM56 OM57 OM66 OM67 OM77 OM67 + ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... OM77 + ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... 1 ************************************************************************************************************************ ******************** ******************** ******************** CORRELATION MATRIX OF ESTIMATE ******************** ******************** ******************** ************************************************************************************************************************ TH 1 TH 2 TH 3 TH 4 TH 5 TH 6 TH 7 OM11 OM12 OM13 OM14 OM15 OM16 OM17 OM22 OM23 OM24 OM25 OM26 OM27 OM33 OM34 OM35 OM36 OM37 OM44 OM45 OM46 OM47 OM55 OM56 OM57 OM66 OM67 OM77 TH 1 + 1.00E+00 TH 2 + -1.00E+00 1.00E+00 TH 3 + ......... ......... ......... TH 4 + -1.00E+00 1.00E+00 ......... 1.00E+00 TH 5 + -1.00E+00 1.00E+00 ......... 1.00E+00 1.00E+00 TH 6 + 1.00E+00 -1.00E+00 ......... -1.00E+00 -1.00E+00 1.00E+00 TH 7 + -1.00E+00 1.00E+00 ......... 1.00E+00 1.00E+00 -1.00E+00 1.00E+00 OM11 + -1.00E+00 1.00E+00 ......... 1.00E+00 1.00E+00 -1.00E+00 1.00E+00 1.00E+00 OM12 + ......... ......... ......... ......... ......... ......... ......... ......... ......... OM13 + ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... OM14 + ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... OM15 + ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... OM16 + ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... OM17 + ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... OM22 + 1.00E+00 -1.00E+00 ......... -1.00E+00 -1.00E+00 1.00E+00 -1.00E+00 -1.00E+00 ......... ......... ......... ......... ......... ......... 1.00E+00 OM23 + ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... OM24 + ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... OM25 + ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... OM26 + ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... 1 TH 1 TH 2 TH 3 TH 4 TH 5 TH 6 TH 7 OM11 OM12 OM13 OM14 OM15 OM16 OM17 OM22 OM23 OM24 OM25 OM26 OM27 OM33 OM34 OM35 OM36 OM37 OM44 OM45 OM46 OM47 OM55 OM56 OM57 OM66 OM67 OM77 OM27 + ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... OM33 + ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... OM34 + ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... OM35 + ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... OM36 + ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... OM37 + ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... OM44 + ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... OM45 + ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... OM46 + ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... OM47 + ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... OM55 + -1.00E+00 1.00E+00 ......... 1.00E+00 1.00E+00 -1.00E+00 1.00E+00 1.00E+00 ......... ......... ......... ......... ......... ......... -1.00E+00 ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... 1.00E+00 OM56 + ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... OM57 + ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... OM66 + -1.00E+00 1.00E+00 ......... 1.00E+00 1.00E+00 -1.00E+00 1.00E+00 1.00E+00 ......... ......... ......... ......... ......... ......... -1.00E+00 ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... 1.00E+00 ......... ......... 1.00E+00 1 TH 1 TH 2 TH 3 TH 4 TH 5 TH 6 TH 7 OM11 OM12 OM13 OM14 OM15 OM16 OM17 OM22 OM23 OM24 OM25 OM26 OM27 OM33 OM34 OM35 OM36 OM37 OM44 OM45 OM46 OM47 OM55 OM56 OM57 OM66 OM67 OM77 OM67 + ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... OM77 + ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... 1 ************************************************************************************************************************ ******************** ******************** ******************** INVERSE COVARIANCE MATRIX OF ESTIMATE ******************** ******************** ******************** ************************************************************************************************************************ TH 1 TH 2 TH 3 TH 4 TH 5 TH 6 TH 7 OM11 OM12 OM13 OM14 OM15 OM16 OM17 OM22 OM23 OM24 OM25 OM26 OM27 OM33 OM34 OM35 OM36 OM37 OM44 OM45 OM46 OM47 OM55 OM56 OM57 OM66 OM67 OM77 TH 1 + 2.15E+07 TH 2 + -4.89E+08 1.11E+10 TH 3 + ......... ......... ......... TH 4 + -1.52E+08 3.47E+09 ......... 1.08E+09 TH 5 + 7.72E+08 -1.76E+10 ......... -5.49E+09 2.78E+10 TH 6 + 6.00E+08 -1.37E+10 ......... -4.26E+09 2.16E+10 1.68E+10 TH 7 + -1.34E+08 3.06E+09 ......... 9.55E+08 -4.84E+09 -3.76E+09 8.43E+08 OM11 + 2.21E+09 -5.03E+10 ......... -1.57E+10 7.96E+10 6.18E+10 -1.39E+10 2.28E+11 OM12 + ......... ......... ......... ......... ......... ......... ......... ......... ......... OM13 + ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... OM14 + ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... OM15 + ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... OM16 + ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... OM17 + ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... OM22 + -1.16E+09 2.65E+10 ......... 8.26E+09 -4.18E+10 -3.25E+10 7.29E+09 -1.20E+11 ......... ......... ......... ......... ......... ......... 6.30E+10 OM23 + ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... OM24 + ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... OM25 + ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... OM26 + ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... 1 TH 1 TH 2 TH 3 TH 4 TH 5 TH 6 TH 7 OM11 OM12 OM13 OM14 OM15 OM16 OM17 OM22 OM23 OM24 OM25 OM26 OM27 OM33 OM34 OM35 OM36 OM37 OM44 OM45 OM46 OM47 OM55 OM56 OM57 OM66 OM67 OM77 OM27 + ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... OM33 + ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... OM34 + ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... OM35 + ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... OM36 + ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... OM37 + ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... OM44 + ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... OM45 + ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... OM46 + ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... OM47 + ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... OM55 + -3.63E+12 8.27E+13 ......... 2.58E+13 -1.31E+14 -1.02E+14 2.28E+13 -3.74E+14 ......... ......... ......... ......... ......... ......... 1.97E+14 ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... 6.14E+17 OM56 + ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... OM57 + ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... OM66 + 6.05E+11 -1.38E+13 ......... -4.30E+12 2.18E+13 1.69E+13 -3.79E+12 6.23E+13 ......... ......... ......... ......... ......... ......... -3.28E+13 ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... -1.02E+17 ......... ......... 1.70E+16 1 TH 1 TH 2 TH 3 TH 4 TH 5 TH 6 TH 7 OM11 OM12 OM13 OM14 OM15 OM16 OM17 OM22 OM23 OM24 OM25 OM26 OM27 OM33 OM34 OM35 OM36 OM37 OM44 OM45 OM46 OM47 OM55 OM56 OM57 OM66 OM67 OM77 OM67 + ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... OM77 + ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... 1THERE ARE ERROR MESSAGES IN FILE PRDERR