TABLE 2. Local cerebral blood flow during desflurane and isoflurane anesthesia in rats
(ml · 100 g^-1 · min^-1).

Control

1 MAC

2 MAC

Isoflurane

Desflurane

Isoflurane

Desflurane

Cerebellum

Cerebellar cortex

89

±

11

139

±

26

128

±

28

232

±

58

215

±

18

Dentate nuclei

140

±

8

228

±

47

245

±

56

346

±

73

370

±

91

Medulla-pons

Vestibular nucleus

118

±

14

236

±

44

220

±

48

332

±

84

323

±

72

Superior olive

143

±

22

244

±

39

264

±

59

351

±

90

365

±

83

Pontine gray

88

±

8

140

±

30

132

±

27

207

±

44

209

±

32

Lateral lemniscus

139

±

10

199

±

42

222

±

59

283

±

66

294

±

53

Mesencephalon

Inferior colliculus

172

±

28

228

±

32

220

±

36

318

±

92

266

±

43

Superior colliculus

105

±

12

140

±

16

136

±

28

206

±

48

187

±

21

Substantia nigra,

84

±

7

118

±

16

125

±

23

194

±

49

192

±

11

compact part

Substantia nigra,

68

±

5

96

±

12

108

±

20

145

±

37

163

±

22

reticular part

Interpeduncular nucleus

134

±

10

197

±

41

236

±

50

295

±

76

303

±

53

Diencephalon

Medial geniculate

142

±

12

154

±

20

151

±

37

219

±

45

193

±

15

Lateral geniculate

112

±

10

129

±

18

124

±

19

183

±

36

166

±

24

Mamillary body

117

±

9

153

±

19

188

±

43

217

±

54

212

±

34

Hypothalamus

74

±

2

92

±

5

103

±

18

130

±

28

126

±

21

Ventral thalamus

117

±

8

133

±

29

128

±

25

198

±

21

211

±

27

Lateral thalamus

120

±

9

136

±

23

123

±

30

184

±

31

162

±

26

Medial habenula

124

±

5

173

±

32

188

±

42

242

±

22

257

±

65

Lateral habenula

153

±

7

195

±

28

207

±

60

270

±

13

281

±

51

Telencephalon

Hippocampus CA1

82

±

17

129

±

29

132

±

46

153

±

25

140

±

11

Hippocampus CA2

69

±

10

118

±

28

120

±

33

145

±

22

129

±

7

Hippocampus CA3

82

±

6

124

±

14

133

±

32

173

±

35

140

±

12

Hippocampus CA4

75

±

6

121

±

20

117

±

24

169

±

30

141

±

8

Dentate gyrus

83

±

12

129

±

20

126

±

33

164

±

31

144

±

16

Amygdaloid complex

76

±

7

102

±

7

109

±

22

131

±

23

130

±

11

Globus pallidus

62

±

6

95

±

15

89

±

18

129

±

23

124

±

17

Caudate nucleus

98

±

5

129

±

20

123

±

26

144

±

15

142

±

16

Nucleus accumbens

105

±

14

131

±

20

134

±

36

143

±

11

128

±

21

Lateral septal nuclei

79

±

7

108

±

15

106

±

25

149

±

17

133

±

12

Cingulate cortex

136

±

18

145

±

24

148

±

38

152

±

15

153

±

27

Visual cortex

111

±

18

133

±

22

134

±

29

124

±

23

120

±

12

Auditory cortex

162

±

22

139

±

17

154

±

35

133

±

20

126

±

16

Parietal cortex

117

±

15

137

±

14

127

±

34

131

±

26

138

±

16

Sensory motor cortex

122

±

12

141

±

20

133

±

36

157

±

18

153

±

24

Frontal cortex

113

±

14

138

±

17

129

±

31

156

±

19

141

±

20

Pyriform cortex

98

±

8

114

±

16

148

±

42

122

±

11

134

±

21

Myelinated fiber tracts

Internal capsule

36

±

3

61

±

14

52

±

9

89

±

9

77

±

9

Corpus callosum

38

±

8

56

±

9

51

±

11

84

±

7

76

±

18

Genu of corpus callosum

38

±

5

65

±

8

57

±

14

85

±

8

72

±

13

Cerebellar white matter

40

±

4

70

±

15

58

±

9

102

±

17

93

±

15

Values are means ± SD of n = 6 in each group.