Category GO Description Timepoint LogP #GeneInGOAndHitList Hits GO Biological Processes GO:0072698 protein localization to microtubule cytoskeleton D1 -4.5 6 Diaph1|Dvl1|Cep250|Mid1|Cep63|Fam83d GO Biological Processes GO:0044380 protein localization to cytoskeleton D1 -4.2 6 Diaph1|Dvl1|Cep250|Mid1|Cep63|Fam83d GO Biological Processes GO:0048668 collateral sprouting D1 -3.3 4 Cobl|Dvl1|Ulk2|Rtn4 GO Biological Processes GO:0035372 protein localization to microtubule D1 -3 3 Diaph1|Dvl1|Mid1 GO Biological Processes GO:0021885 forebrain cell migration D1 -2.7 5 Cxcr4|Tyro3|Rtn4|P2ry12|Cul5 Reactome Gene Sets R-MMU-392170 ADP signalling through P2Y purinoceptor 12 D1 -2.7 3 Gnb1|Gnb5|P2ry12 GO Cellular Components GO:1990234 transferase complex D1 -2.7 19 Acvrl1|Itch|Rb1|Rpn2|Zfp64|Dcaf11|Cdc23|Tmem258|Ankib1|Riok1|Fbxl20|Brap|Prps1l1|Cul5|Cul9|Naa35|Hdac9|Dcun1d1|Brd1 GO Biological Processes GO:0032102 negative regulation of response to external stimulus D1 -2.6 11 Adcy7|Dvl1|Acod1|Itch|Rb1|Ryk|Tyro3|Mapkbp1|Nenf|Rtn4|Dusp3 Reactome Gene Sets R-MMU-1236977 Endosomal/Vacuolar pathway D1 -2.4 3 H2-K1|H2-Q4|H2-M1 GO Cellular Components GO:0070971 endoplasmic reticulum exit site D1 -2.4 3 H2-K1|H2-Q4|Sec23b GO Biological Processes GO:0002507 tolerance induction D1 -2.4 3 Acod1|Itch|Icos Reactome Gene Sets R-MMU-2514856 The phototransduction cascade D1 -2.3 3 Calm1|Gnb1|Gnb5 Reactome Gene Sets R-MMU-418597 G alpha (z) signalling events D1 -2.3 3 Adcy7|Gnb1|Gnb5 GO Biological Processes GO:0051924 regulation of calcium ion transport D1 -2.2 9 Ahr|Capn3|Cxcr4|Diaph1|Gnb5|Rgs4|Gpr35|P2ry12|Jph4 Reactome Gene Sets R-MMU-451326 Activation of kainate receptors upon glutamate binding D1 -2.2 3 Calm1|Gnb1|Gnb5 Reactome Gene Sets R-MMU-112314 Neurotransmitter receptors and postsynaptic signal transmission D1 -2.2 6 Adcy7|Calm1|Gabrr1|Gnb1|Gnb5|Chrnb4 GO Biological Processes GO:0002486 antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TA D1 -2.2 3 H2-K1|H2-Q4|H2-M1 Reactome Gene Sets R-MMU-392518 Signal amplification D1 -2.2 3 Gnb1|Gnb5|P2ry12 GO Biological Processes GO:0002476 antigen processing and presentation of endogenous peptide antigen via MHC class Ib D1 -2.2 3 H2-K1|H2-Q4|H2-M1 GO Biological Processes GO:0002484 antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway D1 -2.2 3 H2-K1|H2-Q4|H2-M1 GO Cellular Components GO:0000151 ubiquitin ligase complex D1 -2.1 9 Itch|Dcaf11|Cdc23|Ankib1|Fbxl20|Brap|Cul5|Cul9|Dcun1d1 KEGG Pathway mmu05166 HTLV-I infection D1 -2.1 9 Adcy7|Dvl1|H2-K1|H2-Q4|Rb1|Wnt8a|Cdc23|Tnfrsf13c|H2-M1 GO Biological Processes GO:0009611 response to wounding D1 -2.1 13 Macf1|Acta2|Acvrl1|Adam17|Capn3|Cxcr4|Clec10a|Tyro3|Rtn4|P2ry12|Treml1|3300005D01Rik|Enpp4 GO Biological Processes GO:0006487 protein N-linked glycosylation D1 -2.1 4 Rpn2|Alg2|Tmem258|Mgat4b GO Biological Processes GO:0002428 antigen processing and presentation of peptide antigen via MHC class Ib D1 -2.1 3 H2-K1|H2-Q4|H2-M1 GO Biological Processes GO:0002224 toll-like receptor signaling pathway D1 -2.1 5 Cd14|Acod1|Tyro3|Rtn4|Mapkapk3 Reactome Gene Sets R-MMU-1236974 ER-Phagosome pathway D1 -2.1 3 H2-K1|H2-Q4|H2-M1 GO Molecular Functions GO:0060589 nucleoside-triphosphatase regulator activity D1 -2 9 Gnb5|Rangap1|Rgs4|Sec23b|Tbc1d2b|Smap2|Tor1aip1|Tor1aip2|Sipa1l2 Reactome Gene Sets R-MMU-111885 Opioid Signalling D1 -2 4 Adcy7|Calm1|Gnb1|Gnb5 GO Biological Processes GO:0045446 endothelial cell differentiation D1 -2 5 Acvrl1|Cxcr4|Ren1|Xdh|Rtn4 GO Biological Processes GO:0021799 cerebral cortex radially oriented cell migration D1 -2 3 Rtn4|P2ry12|Cul5 GO Biological Processes GO:0060071 Wnt signaling pathway, planar cell polarity pathway D1 -2 3 Dvl1|Ryk|Nkd1 GO Biological Processes GO:0001782 B cell homeostasis D1 -2 3 Ahr|Tnfrsf13c|Dock10 GO Biological Processes GO:0022029 telencephalon cell migration D1 -2 4 Cxcr4|Rtn4|P2ry12|Cul5 GO Molecular Functions GO:0005198 structural molecule activity D1 -2 15 Macf1|Bglap3|Capn3|Col7a1|Krt31|Lamc2|Rpl22|Rps7|Sprr2b|Sprr2d|Igfbp7|Cldn15|Mrps14|Prelp|Krt26 Reactome Gene Sets R-MMU-112315 Transmission across Chemical Synapses D1 -2 7 Adcy7|Calm1|Gabrr1|Gnb1|Gnb5|Naaa|Chrnb4 GO Biological Processes GO:0002475 antigen processing and presentation via MHC class Ib D1 -2 3 H2-K1|H2-Q4|H2-M1 GO Biological Processes GO:0002483 antigen processing and presentation of endogenous peptide antigen D1 -1.9 3 H2-K1|H2-Q4|H2-M1 GO Biological Processes GO:0019885 antigen processing and presentation of endogenous peptide antigen via MHC class I D1 -1.9 3 H2-K1|H2-Q4|H2-M1 GO Biological Processes GO:0090175 regulation of establishment of planar polarity D1 -1.9 3 Dvl1|Ryk|Nkd1 GO Biological Processes GO:1990845 adaptive thermogenesis D1 -1.9 6 Adam17|Aldh1a1|Cxcr4|Rb1|Ucp3|Ybx2 GO Biological Processes GO:1903036 positive regulation of response to wounding D1 -1.9 4 Capn3|Cxcr4|Rtn4|Enpp4 KEGG Pathway mmu04725 Cholinergic synapse D1 -1.9 5 Adcy7|Gnb1|Gnb5|Chrnb4|Kcnj14 GO Biological Processes GO:0032101 regulation of response to external stimulus D1 -1.9 17 Adam17|Adcy7|Cd5l|Capn3|Cxcr4|Dvl1|Acod1|Itch|Rb1|Ryk|Tyro3|Mapkbp1|Nenf|Rtn4|P2ry12|Dusp3|Enpp4 GO Biological Processes GO:0000266 mitochondrial fission D1 -1.9 3 Ggnbp1|Opa1|Ddhd1 GO Biological Processes GO:0042060 wound healing D1 -1.9 10 Macf1|Acta2|Acvrl1|Capn3|Cxcr4|Clec10a|Tyro3|P2ry12|Treml1|Enpp4 GO Biological Processes GO:0051303 establishment of chromosome localization D1 -1.9 4 Cep63|Cdc23|Fam83d|Trappc12 GO Biological Processes GO:0002832 negative regulation of response to biotic stimulus D1 -1.9 3 Acod1|Itch|Mapkbp1 GO Biological Processes GO:1903170 negative regulation of calcium ion transmembrane transport D1 -1.9 3 Ahr|Gnb5|Gpr35 GO Biological Processes GO:0050000 chromosome localization D1 -1.9 4 Cep63|Cdc23|Fam83d|Trappc12 GO Biological Processes GO:0048041 focal adhesion assembly D1 -1.9 4 Macf1|Acvrl1|Dusp3|Tesk2 GO Biological Processes GO:0007045 cell-substrate adherens junction assembly D1 -1.9 4 Macf1|Acvrl1|Dusp3|Tesk2 Reactome Gene Sets R-MMU-3858494 Beta-catenin independent WNT signaling D1 -1.9 4 Calm1|Dvl1|Gnb1|Gnb5 Reactome Gene Sets R-MMU-983170 Antigen Presentation: Folding, assembly and peptide loading of class I MHC D1 -1.9 3 H2-K1|H2-Q4|H2-M1 GO Molecular Functions GO:0005109 frizzled binding D1 -1.9 3 Dvl1|Ryk|Wnt8a GO Biological Processes GO:0019883 antigen processing and presentation of endogenous antigen D1 -1.9 3 H2-K1|H2-Q4|H2-M1 Reactome Gene Sets R-MMU-4086398 Ca2+ pathway D1 -1.8 3 Calm1|Gnb1|Gnb5 GO Cellular Components GO:0009925 basal plasma membrane D1 -1.8 3 Myo1c|P2ry12|Slco2b1 KEGG Pathway mmu04672 Intestinal immune network for IgA production D1 -1.8 3 Cxcr4|Icos|Tnfrsf13c GO Molecular Functions GO:1901618 organic hydroxy compound transmembrane transporter activity D1 -1.8 3 Stra6|Slc16a3|Slco2b1 GO Molecular Functions GO:0019199 transmembrane receptor protein kinase activity D1 -1.8 4 Acvrl1|Ryk|Tyro3|Epha10 GO Biological Processes GO:0003158 endothelium development D1 -1.8 5 Acvrl1|Cxcr4|Ren1|Xdh|Rtn4 Reactome Gene Sets R-MMU-1227986 Signaling by ERBB2 D1 -1.8 3 Diaph1|Grb7|Cul5 Reactome Gene Sets R-MMU-112316 Neuronal System D1 -1.8 9 Adcy7|Calm1|Gabrr1|Gnb1|Gnb5|Naaa|Chrnb4|Kcnj14|Kcnk18 GO Cellular Components GO:0001750 photoreceptor outer segment D1 -1.8 4 Gnb1|Gnb5|Cep250|Prom1 KEGG Pathway mmu04514 Cell adhesion molecules (CAMs) D1 -1.8 6 Cntn1|H2-K1|H2-Q4|Icos|Cldn15|H2-M1 GO Biological Processes GO:0060560 developmental growth involved in morphogenesis D1 -1.8 8 Ahr|Cxcr4|Cobl|Dvl1|Ryk|Ulk2|Rtn4|Nkd1 GO Biological Processes GO:0001961 positive regulation of cytokine-mediated signaling pathway D1 -1.8 3 Adam17|Cxcr4|Txk GO Molecular Functions GO:0005044 scavenger receptor activity D1 -1.8 3 Cd5l|Lgals3bp|Tmprss13 GO Molecular Functions GO:0044389 ubiquitin-like protein ligase binding D1 -1.8 9 Cxcr4|Itch|Mid1|Rangap1|Rb1|Traf5|Rtn4|Cul5|Cul9 GO Biological Processes GO:1901888 regulation of cell junction assembly D1 -1.8 4 Macf1|Acvrl1|Myo1c|Dusp3 GO Biological Processes GO:0048536 spleen development D1 -1.8 3 Adam17|Ahr|Flvcr1 GO Biological Processes GO:0007212 dopamine receptor signaling pathway D1 -1.8 3 Gnb5|Nsg2|Rgs4 GO Molecular Functions GO:0042605 peptide antigen binding D1 -1.8 3 H2-K1|H2-Q4|H2-M1 GO Biological Processes GO:0048640 negative regulation of developmental growth D1 -1.7 5 Rgs4|Ryk|Ulk2|Rtn4|Nkd1 GO Biological Processes GO:0031644 regulation of neurological system process D1 -1.7 6 Dvl1|Rgs4|Gpr35|Rtn4|Chrnb4|Zfhx2 GO Biological Processes GO:0120163 negative regulation of cold-induced thermogenesis D1 -1.7 3 Adam17|Aldh1a1|Rb1 GO Biological Processes GO:0034333 adherens junction assembly D1 -1.7 4 Macf1|Acvrl1|Dusp3|Tesk2 Reactome Gene Sets R-MMU-1236975 Antigen processing-Cross presentation D1 -1.7 3 H2-K1|H2-Q4|H2-M1 GO Biological Processes GO:0007131 reciprocal meiotic recombination D1 -1.7 3 Cep63|Tex11|Fancm GO Cellular Components GO:0005795 Golgi stack D1 -1.7 4 H2-K1|H2-Q4|Nsg2|Mgat4b GO Biological Processes GO:0032606 type I interferon production D1 -1.7 4 Cd14|Acod1|Irf9|Zfp64 GO Biological Processes GO:0007044 cell-substrate junction assembly D1 -1.7 4 Macf1|Acvrl1|Dusp3|Tesk2 GO Biological Processes GO:0035825 homologous recombination D1 -1.7 3 Cep63|Tex11|Fancm KEGG Pathway mmu00510 N-Glycan biosynthesis D1 -1.7 3 Rpn2|Alg2|Mgat4b GO Biological Processes GO:0001916 positive regulation of T cell mediated cytotoxicity D1 -1.7 3 H2-K1|H2-Q4|H2-M1 GO Biological Processes GO:0002474 antigen processing and presentation of peptide antigen via MHC class I D1 -1.7 3 H2-K1|H2-Q4|H2-M1 GO Biological Processes GO:1903034 regulation of response to wounding D1 -1.7 6 Acta2|Adam17|Capn3|Cxcr4|Rtn4|Enpp4 KEGG Pathway mmu04727 GABAergic synapse D1 -1.7 4 Adcy7|Gabrr1|Gnb1|Gnb5 KEGG Pathway mmu05203 Viral carcinogenesis D1 -1.7 7 H2-K1|H2-Q4|Irf9|Rb1|Traf5|Hdac9|H2-M1 GO Molecular Functions GO:0004713 protein tyrosine kinase activity D1 -1.7 5 Ryk|Txk|Tyro3|Tesk2|Epha10 GO Biological Processes GO:0030098 lymphocyte differentiation D1 -1.7 10 Adam17|Ahr|Rpl22|Txk|Tyro3|Nfam1|Rhoh|Hdac9|Dock10|Btnl6 GO Biological Processes GO:1904063 negative regulation of cation transmembrane transport D1 -1.7 4 Ahr|Gnb5|Rgs4|Gpr35 KEGG Pathway mmu04144 Endocytosis D1 -1.7 8 Cxcr4|H2-K1|H2-Q4|Itch|Wipf2|Smap2|Dnajc6|H2-M1 GO Biological Processes GO:1900076 regulation of cellular response to insulin stimulus D1 -1.6 4 Bglap3|Grb7|Myo1c|Opa1 GO Cellular Components GO:0060170 ciliary membrane D1 -1.6 3 Gnb1|Prom1|Ift46 GO Biological Processes GO:0060760 positive regulation of response to cytokine stimulus D1 -1.6 3 Adam17|Cxcr4|Txk GO Biological Processes GO:0007032 endosome organization D1 -1.6 3 Stx6|Ggnbp1|Pheta2 Reactome Gene Sets R-MMU-2424491 DAP12 signaling D1 -1.6 3 H2-K1|H2-Q4|H2-M1 GO Biological Processes GO:0046683 response to organophosphorus D1 -1.6 4 Ahr|Ren1|Dntt|P2ry12 GO Biological Processes GO:0002221 pattern recognition receptor signaling pathway D1 -1.6 5 Cd14|Acod1|Tyro3|Rtn4|Mapkapk3 KEGG Pathway mmu05032 Morphine addiction D1 -1.6 4 Adcy7|Gabrr1|Gnb1|Gnb5 Reactome Gene Sets R-MMU-2187338 Visual phototransduction D1 -1.6 4 Calm1|Gnb1|Gnb5|Stra6 GO Molecular Functions GO:0005096 GTPase activator activity D1 -1.6 7 Gnb5|Rangap1|Rgs4|Sec23b|Tbc1d2b|Smap2|Sipa1l2 Reactome Gene Sets R-MMU-977443 GABA receptor activation D1 -1.6 3 Adcy7|Gabrr1|Gnb1 GO Biological Processes GO:0002758 innate immune response-activating signal transduction D1 -1.6 5 Cd14|Acod1|Tyro3|Rtn4|Mapkapk3 GO Cellular Components GO:0030425 dendrite D1 -1.6 15 Acvrl1|Bglap3|Cobl|Dvl1|Gnb1|Nsg2|Rangap1|Rtn4|Ggnbp1|Opa1|Dock10|Kcnj14|Farp1|Brd1|Jph4 KEGG Pathway mmu04120 Ubiquitin mediated proteolysis D1 -1.6 5 Itch|Mid1|Cdc23|Cul5|Nhlrc1 KEGG Pathway mmu04371 Apelin signaling pathway D1 -1.6 5 Acta2|Adcy7|Calm1|Gnb1|Gnb5 GO Biological Processes GO:0001914 regulation of T cell mediated cytotoxicity D1 -1.6 3 H2-K1|H2-Q4|H2-M1 Reactome Gene Sets R-MMU-72187 mRNA 3'-end processing D1 -1.6 3 Cpsf3|Ddx39|Cstf2t GO Biological Processes GO:0070838 divalent metal ion transport D1 -1.6 11 Ahr|Capn3|Cxcr4|Diaph1|Gnb5|Rgs4|Gpr35|P2ry12|Slc39a4|Opa1|Jph4 GO Biological Processes GO:0051304 chromosome separation D1 -1.6 4 Rb1|Cdc23|Tex11|Fancm GO Cellular Components GO:0097447 dendritic tree D1 -1.6 15 Acvrl1|Bglap3|Cobl|Dvl1|Gnb1|Nsg2|Rangap1|Rtn4|Ggnbp1|Opa1|Dock10|Kcnj14|Farp1|Brd1|Jph4 GO Biological Processes GO:0021795 cerebral cortex cell migration D1 -1.6 3 Rtn4|P2ry12|Cul5 GO Biological Processes GO:0106106 cold-induced thermogenesis D1 -1.6 5 Adam17|Aldh1a1|Cxcr4|Rb1|Ybx2 GO Biological Processes GO:0120161 regulation of cold-induced thermogenesis D1 -1.6 5 Adam17|Aldh1a1|Cxcr4|Rb1|Ybx2 GO Biological Processes GO:0072511 divalent inorganic cation transport D1 -1.5 11 Ahr|Capn3|Cxcr4|Diaph1|Gnb5|Rgs4|Gpr35|P2ry12|Slc39a4|Opa1|Jph4 GO Biological Processes GO:0090303 positive regulation of wound healing D1 -1.5 3 Capn3|Cxcr4|Enpp4 GO Biological Processes GO:1905517 macrophage migration D1 -1.5 3 Gpr35|Rtn4|P2ry12 GO Biological Processes GO:0035567 non-canonical Wnt signaling pathway D1 -1.5 3 Dvl1|Ryk|Nkd1 KEGG Pathway mmu04713 Circadian entrainment D1 -1.5 4 Adcy7|Calm1|Gnb1|Gnb5 Reactome Gene Sets R-MMU-6805567 Keratinization D1 -1.5 6 Krt31|Krtap9-1|Sprr2d|Krt26|Gm11568|Gm11563 Reactome Gene Sets R-MMU-418594 G alpha (i) signalling events D1 -1.5 9 Adcy7|Calm1|Cxcr4|Gnb1|Gnb5|Rgs4|Stra6|P2ry12|Npb GO Biological Processes GO:0051310 metaphase plate congression D1 -1.5 3 Cdc23|Fam83d|Trappc12 GO Biological Processes GO:0001736 establishment of planar polarity D1 -1.5 3 Dvl1|Ryk|Nkd1 GO Biological Processes GO:0051893 regulation of focal adhesion assembly D1 -1.5 3 Macf1|Acvrl1|Dusp3 GO Biological Processes GO:0090109 regulation of cell-substrate junction assembly D1 -1.5 3 Macf1|Acvrl1|Dusp3 GO Cellular Components GO:0001917 photoreceptor inner segment D1 -1.5 3 Gnb1|Gnb5|Cep250 GO Biological Processes GO:0010959 regulation of metal ion transport D1 -1.5 10 Ahr|Capn3|Cxcr4|Cntn1|Diaph1|Gnb5|Rgs4|Gpr35|P2ry12|Jph4 GO Molecular Functions GO:0031625 ubiquitin protein ligase binding D1 -1.5 8 Cxcr4|Mid1|Rangap1|Rb1|Traf5|Rtn4|Cul5|Cul9 GO Biological Processes GO:0006816 calcium ion transport D1 -1.5 10 Ahr|Capn3|Cxcr4|Diaph1|Gnb5|Rgs4|Gpr35|P2ry12|Opa1|Jph4 GO Biological Processes GO:0031343 positive regulation of cell killing D1 -1.5 4 Cd5l|H2-K1|H2-Q4|H2-M1 KEGG Pathway mmu04916 Melanogenesis D1 -1.5 4 Adcy7|Calm1|Dvl1|Wnt8a GO Cellular Components GO:0016328 lateral plasma membrane D1 -1.5 3 Dvl1|Myo1c|Cldn15 GO Biological Processes GO:0007164 establishment of tissue polarity D1 -1.5 3 Dvl1|Ryk|Nkd1 GO Biological Processes GO:0007264 small GTPase mediated signal transduction D1 -1.5 11 Mapkapk5|Arpp19|Gpr35|Ift22|Rtn4|Ggnbp1|Brap|Rhoh|Dock10|Farp1|Sipa1l2 GO Biological Processes GO:0048469 cell maturation D1 -1.5 6 Rb1|Ren1|Opa1|Flvcr1|Svs3b|Angptl8 Reactome Gene Sets R-MMU-2172127 DAP12 interactions D1 -1.5 3 H2-K1|H2-Q4|H2-M1 KEGG Pathway mmu04723 Retrograde endocannabinoid signaling D1 -1.5 4 Adcy7|Gabrr1|Gnb1|Gnb5 GO Biological Processes GO:0048729 tissue morphogenesis D1 -1.5 14 Macf1|Acvrl1|Ahr|Aldh1a1|Cxcr4|Cobl|Col7a1|Dvl1|Rps7|Ryk|Txnrd1|Ccdc103|Opa1|Nkd1 GO Biological Processes GO:0030183 B cell differentiation D1 -1.5 5 Adam17|Ahr|Nfam1|Hdac9|Dock10 GO Molecular Functions GO:0030695 GTPase regulator activity D1 -1.5 7 Gnb5|Rangap1|Rgs4|Sec23b|Tbc1d2b|Smap2|Sipa1l2 GO Biological Processes GO:0098813 nuclear chromosome segregation D1 -1.4 7 Rb1|Cep63|Cdc23|Fam83d|Tex11|Fancm|Trappc12 GO Biological Processes GO:0048588 developmental cell growth D1 -1.4 7 Cxcr4|Cobl|Dvl1|Rgs4|Ryk|Ulk2|Rtn4 GO Biological Processes GO:0034766 negative regulation of ion transmembrane transport D1 -1.4 4 Ahr|Gnb5|Rgs4|Gpr35 GO Biological Processes GO:0007059 chromosome segregation D1 -1.4 8 Rb1|Cep63|Cdc23|Fam83d|Tex11|Fancm|Trappc12|Banf2 GO Cellular Components GO:0031985 Golgi cisterna D1 -1.4 3 H2-K1|H2-Q4|Nsg2 GO Molecular Functions GO:0004714 transmembrane receptor protein tyrosine kinase activity D1 -1.4 3 Ryk|Tyro3|Epha10 Reactome Gene Sets R-MMU-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell D1 -1.4 4 H2-K1|H2-Q4|Treml1|H2-M1 GO Biological Processes GO:0060840 artery development D1 -1.4 4 Acvrl1|Cxcr4|Stra6|Rtn4 GO Cellular Components GO:0072686 mitotic spindle D1 -1.4 4 Diaph1|Rangap1|Mapkbp1|Fam83d GO Biological Processes GO:0014074 response to purine-containing compound D1 -1.4 4 Ahr|Ren1|Dntt|P2ry12 GO Biological Processes GO:0046579 positive regulation of Ras protein signal transduction D1 -1.4 3 Arpp19|Gpr35|Rtn4 GO Biological Processes GO:0034121 regulation of toll-like receptor signaling pathway D1 -1.4 3 Acod1|Tyro3|Rtn4 Reactome Gene Sets R-MMU-73856 RNA Polymerase II Transcription Termination D1 -1.4 3 Cpsf3|Ddx39|Cstf2t KEGG Pathway mmu05330 Allograft rejection D1 -1.4 3 H2-K1|H2-Q4|H2-M1 GO Biological Processes GO:0051926 negative regulation of calcium ion transport D1 -1.4 3 Ahr|Gnb5|Gpr35 GO Biological Processes GO:1903391 regulation of adherens junction organization D1 -1.4 3 Macf1|Acvrl1|Dusp3 GO Cellular Components GO:0031461 cullin-RING ubiquitin ligase complex D1 -1.4 5 Dcaf11|Cdc23|Fbxl20|Cul5|Cul9 KEGG Pathway mmu05332 Graft-versus-host disease D1 -1.4 3 H2-K1|H2-Q4|H2-M1 GO Biological Processes GO:0001843 neural tube closure D1 -1.4 4 Cobl|Dvl1|Rps7|Opa1 GO Biological Processes GO:0001776 leukocyte homeostasis D1 -1.4 4 Adam17|Ahr|Tnfrsf13c|Dock10 GO Biological Processes GO:1903169 regulation of calcium ion transmembrane transport D1 -1.4 5 Ahr|Capn3|Diaph1|Gnb5|Gpr35 GO Biological Processes GO:0060606 tube closure D1 -1.4 4 Cobl|Dvl1|Rps7|Opa1 GO Cellular Components GO:0045178 basal part of cell D1 -1.4 3 Myo1c|P2ry12|Slco2b1 GO Biological Processes GO:1901184 regulation of ERBB signaling pathway D1 -1.4 3 Adam17|Rtn4|Dusp3 GO Biological Processes GO:0016049 cell growth D1 -1.3 11 Acvrl1|Adam17|Cxcr4|Cobl|Dvl1|Rb1|Rgs4|Ryk|Igfbp7|Ulk2|Rtn4 Reactome Gene Sets R-MMU-9006934 Signaling by Receptor Tyrosine Kinases D1 -1.3 9 Calm1|Diaph1|Grb7|Itch|Dusp3|Cul5|Rbfox2|Mapkapk3|Atp6v0b GO Biological Processes GO:0033365 protein localization to organelle D1 -1.3 15 Macf1|Diaph1|Dvl1|Cep250|Mid1|Rangap1|Rb1|Cep63|Rtn4|Fam83d|Tor1aip1|Trappc12|Tor1aip2|1700015F17Rik|Mir208b GO Biological Processes GO:0050771 negative regulation of axonogenesis D1 -1.3 3 Ryk|Ulk2|Rtn4 GO Cellular Components GO:0005819 spindle D1 -1.3 7 Diaph1|Cep250|Rangap1|Rb1|Mapkbp1|Fam83d|Bora GO Cellular Components GO:0097733 photoreceptor cell cilium D1 -1.3 4 Gnb1|Gnb5|Cep250|Prom1 GO Biological Processes GO:0002218 activation of innate immune response D1 -1.3 5 Cd14|Acod1|Tyro3|Rtn4|Mapkapk3 KEGG Pathway mmu05200 Pathways in cancer D1 -1.3 9 Adcy7|Cxcr4|Dvl1|Gnb1|Gnb5|Lamc2|Rb1|Wnt8a|Traf5 GO Biological Processes GO:0048002 antigen processing and presentation of peptide antigen D1 -1.3 3 H2-K1|H2-Q4|H2-M1 GO Cellular Components GO:0043235 receptor complex D1 -1.3 9 Acvrl1|Ahr|Cd14|Gabrr1|Ryk|Traf5|Tyro3|Chrnb4|Epha10 GO Biological Processes GO:0048285 organelle fission D1 -1.3 10 Rb1|Cep63|Cdc23|Ggnbp1|Opa1|Bora|Cul9|Tex11|Fancm|Ddhd1 GO Biological Processes GO:0031348 negative regulation of defense response D1 -1.3 6 Adcy7|Acod1|Itch|Rb1|Tyro3|Mapkbp1 GO Cellular Components GO:0097731 9+0 non-motile cilium D1 -1.3 4 Gnb1|Gnb5|Cep250|Prom1 GO Biological Processes GO:0043122 regulation of I-kappaB kinase/NF-kappaB signaling D1 -1.3 5 Capn3|Traf5|Mapkbp1|Rhoh|Unc5cl GO Cellular Components GO:0032587 ruffle membrane D1 -1.3 3 Adam17|Diaph1|Myo1c GO Biological Processes GO:0048678 response to axon injury D1 -1.3 3 Adam17|Rtn4|P2ry12 GO Cellular Components GO:0005793 endoplasmic reticulum-Golgi intermediate compartment D1 -1.3 3 Prom1|Mgat4b|Trappc12 GO Biological Processes GO:0060997 dendritic spine morphogenesis D1 -1.3 3 Dvl1|Opa1|Dock10 GO Molecular Functions GO:0043236 laminin binding W2 -4.8 5 Itga2|Rpsa|2300002M23Rik|Tinagl1|Itga9 GO Biological Processes GO:0018149 peptide cross-linking W2 -4.3 6 Sprr2d|Sprr2e|Sprr3|Tgm2|Lelp1|Lce3e GO Molecular Functions GO:0005184 neuropeptide hormone activity W2 -3.9 4 Gal|Ppy|Qrfp|Nppa GO Biological Processes GO:0086016 AV node cell action potential W2 -3.7 3 Cacna1g|Ryr2|Scn10a GO Biological Processes GO:0086027 AV node cell to bundle of His cell signaling W2 -3.7 3 Cacna1g|Ryr2|Scn10a Reactome Gene Sets R-MMU-6809371 Formation of the cornified envelope W2 -3.6 7 Krt31|Krt6a|Sprr2d|Sprr2e|Sprr3|Lelp1|Lipk GO Cellular Components GO:0001533 cornified envelope W2 -3.5 5 Sprr2d|Sprr2e|Sprr3|Lelp1|Lce3e GO Biological Processes GO:0086067 AV node cell to bundle of His cell communication W2 -3.5 3 Cacna1g|Ryr2|Scn10a GO Biological Processes GO:0030029 actin filament-based process W2 -3.4 19 Bst1|Cacna1g|Capn3|Capza3|Epb41l1|Myh2|Ran|Ryr2|Tesk1|Shroom3|Wipf2|Rhoh|Elmo1|Mical3|Pdlim2|Rasa1|Fhdc1|Gba2|Ablim3 GO Molecular Functions GO:0050840 extracellular matrix binding W2 -3.4 5 Itga2|Rpsa|2300002M23Rik|Tinagl1|Itga9 GO Molecular Functions GO:0005198 structural molecule activity W2 -3.3 17 Capn3|Col4a1|Epb41l1|Krt31|Rpsa|Sprr2d|Sprr2e|Sprr3|Igfbp7|Col6a4|Lelp1|Lce3e|Tinagl1|Mrps2|Nup214|Otol1|Sntg2 GO Biological Processes GO:0031424 keratinization W2 -3.3 4 Krt6a|Sprr2d|Sprr2e|Sprr3 GO Molecular Functions GO:0003779 actin binding W2 -3.2 13 Capza3|Cxcr4|Epb41l1|Tns1|Mprip|Shroom3|Wipf2|Mical3|Pdlim2|Tns4|Fhdc1|Sntg2|Ablim3 GO Biological Processes GO:0030216 keratinocyte differentiation W2 -3.2 7 Krt6a|Foxc1|Sprr2d|Sprr2e|Sprr3|Lelp1|Lce3e GO Molecular Functions GO:0140097 catalytic activity, acting on DNA W2 -3 8 Dnmt1|Ercc1|Rad54l|Tert|Top2a|Ercc5|Mutyh|Eri2 GO Biological Processes GO:0043588 skin development W2 -2.9 10 Gal|Itga2|Krt6a|Foxc1|Sprr2d|Sprr2e|Sprr3|Elovl1|Lelp1|Lce3e GO Molecular Functions GO:0008327 methyl-CpG binding W2 -2.9 3 Dnmt1|Mbd3l2|Zbtb38 GO Biological Processes GO:0006941 striated muscle contraction W2 -2.8 7 Chrng|Cacna1g|Cxcr4|Gaa|Ryr2|Scn10a|Nppa GO Biological Processes GO:0030036 actin cytoskeleton organization W2 -2.7 16 Bst1|Capn3|Capza3|Epb41l1|Ran|Tesk1|Shroom3|Wipf2|Rhoh|Elmo1|Mical3|Pdlim2|Rasa1|Fhdc1|Gba2|Ablim3 GO Biological Processes GO:0060048 cardiac muscle contraction W2 -2.7 6 Cacna1g|Cxcr4|Gaa|Ryr2|Scn10a|Nppa GO Biological Processes GO:0086019 cell-cell signaling involved in cardiac conduction W2 -2.6 3 Cacna1g|Ryr2|Scn10a GO Biological Processes GO:0090316 positive regulation of intracellular protein transport W2 -2.6 6 Ran|Ccl2|Sorl1|Pdzk1|Fis1|Edem2 GO Biological Processes GO:0090303 positive regulation of wound healing W2 -2.5 4 Capn3|Cxcr4|Ccl2|Enpp4 GO Biological Processes GO:0090314 positive regulation of protein targeting to membrane W2 -2.5 3 Ccl2|Pdzk1|Fis1 GO Biological Processes GO:0034764 positive regulation of transmembrane transport W2 -2.5 8 Capn3|Gal|Ryr2|Ccl2|Tert|Pdzk1|Rasa1|Nppa GO Biological Processes GO:0070098 chemokine-mediated signaling pathway W2 -2.4 4 Cxcr4|Foxc1|Ccl2|Ccl7 GO Biological Processes GO:0006936 muscle contraction W2 -2.4 9 Chrng|Cacna1g|Cxcr4|Gaa|Itga2|Myh2|Ryr2|Scn10a|Nppa GO Cellular Components GO:0044215 other organism W2 -2.4 3 C4b|Top2a|Iigp1 GO Molecular Functions GO:0071855 neuropeptide receptor binding W2 -2.4 3 Gal|Qrfp|Nppa GO Cellular Components GO:0044217 other organism part W2 -2.4 3 C4b|Top2a|Iigp1 GO Cellular Components GO:0044216 other organism cell W2 -2.4 3 C4b|Top2a|Iigp1 GO Cellular Components GO:0030864 cortical actin cytoskeleton W2 -2.4 5 Capza3|Myh2|Shroom3|Wipf2|Pdlim2 Reactome Gene Sets R-MMU-6805567 Keratinization W2 -2.3 7 Krt31|Krt6a|Sprr2d|Sprr2e|Sprr3|Lelp1|Lipk GO Cellular Components GO:0031012 extracellular matrix W2 -2.3 12 Col4a1|Rpsa|Lgals4|Tgm2|Gpc6|Igfbp7|Hapln3|Col6a4|2300002M23Rik|Rarres2|Tinagl1|Otol1 GO Cellular Components GO:0062023 collagen-containing extracellular matrix W2 -2.3 10 Col4a1|Rpsa|Lgals4|Tgm2|Gpc6|Igfbp7|Col6a4|2300002M23Rik|Rarres2|Tinagl1 GO Cellular Components GO:0045178 basal part of cell W2 -2.3 4 Itga2|Slco2b1|Itga9|Oscp1 GO Biological Processes GO:0090313 regulation of protein targeting to membrane W2 -2.3 3 Ccl2|Pdzk1|Fis1 GO Biological Processes GO:0032388 positive regulation of intracellular transport W2 -2.3 7 Ran|Ccl2|Sorl1|Pdzk1|Fis1|Edem2|Nppa GO Biological Processes GO:0014823 response to activity W2 -2.2 3 Capn3|Myh2|Ryr2 GO Biological Processes GO:1990868 response to chemokine W2 -2.2 4 Cxcr4|Foxc1|Ccl2|Ccl7 GO Biological Processes GO:1990869 cellular response to chemokine W2 -2.2 4 Cxcr4|Foxc1|Ccl2|Ccl7 GO Cellular Components GO:0044448 cell cortex part W2 -2.2 7 Capza3|Fabp1|Myh2|Shroom3|Exoc7|Wipf2|Pdlim2 GO Biological Processes GO:0086065 cell communication involved in cardiac conduction W2 -2.2 3 Cacna1g|Ryr2|Scn10a GO Biological Processes GO:0033157 regulation of intracellular protein transport W2 -2.1 7 Bard1|Ran|Ccl2|Sorl1|Pdzk1|Fis1|Edem2 GO Biological Processes GO:0032414 positive regulation of ion transmembrane transporter activity W2 -2.1 5 Gal|Ryr2|Ccl2|Pdzk1|Nppa GO Biological Processes GO:1903036 positive regulation of response to wounding W2 -2.1 4 Capn3|Cxcr4|Ccl2|Enpp4 GO Biological Processes GO:0009913 epidermal cell differentiation W2 -2.1 7 Krt6a|Foxc1|Sprr2d|Sprr2e|Sprr3|Lelp1|Lce3e GO Biological Processes GO:1904064 positive regulation of cation transmembrane transport W2 -2.1 6 Capn3|Gal|Ryr2|Ccl2|Pdzk1|Nppa GO Biological Processes GO:0003012 muscle system process W2 -2 10 Chrng|Cacna1g|Cxcr4|Gaa|Itga2|Myh2|Ryr2|Scn10a|Lmcd1|Nppa GO Biological Processes GO:0032411 positive regulation of transporter activity W2 -2 5 Gal|Ryr2|Ccl2|Pdzk1|Nppa GO Biological Processes GO:0071621 granulocyte chemotaxis W2 -2 5 Bst1|Ccl2|Ccl7|Rarres2|Itga9 GO Cellular Components GO:0009925 basal plasma membrane W2 -2 3 Slco2b1|Itga9|Oscp1 GO Molecular Functions GO:0016798 hydrolase activity, acting on glycosyl bonds W2 -2 5 Bst1|Gaa|Mutyh|Edem2|Gba2 GO Biological Processes GO:0007218 neuropeptide signaling pathway W2 -2 4 Gal|Ppy|Qrfp|Nppa GO Cellular Components GO:0001750 photoreceptor outer segment W2 -2 4 Cep250|Prom1|Ahi1|Shoc2 GO Biological Processes GO:0001569 branching involved in blood vessel morphogenesis W2 -1.9 3 Cxcr4|Col4a1|Notch4 KEGG Pathway mmu04512 ECM-receptor interaction W2 -1.9 4 Col4a1|Itga2|Col6a4|Itga9 GO Molecular Functions GO:0005179 hormone activity W2 -1.9 5 Gal|Ppy|Qrfp|Nppa|Angptl8 GO Biological Processes GO:0010951 negative regulation of endopeptidase activity W2 -1.9 6 Serpina6|Cdkn2d|Fabp1|Sorl1|Serpina1f|Nle1 GO Biological Processes GO:0034767 positive regulation of ion transmembrane transport W2 -1.9 6 Capn3|Gal|Ryr2|Ccl2|Pdzk1|Nppa GO Biological Processes GO:0010259 multicellular organism aging W2 -1.9 3 Ercc1|Rad54l|Ercc5 GO Cellular Components GO:0030863 cortical cytoskeleton W2 -1.9 5 Capza3|Myh2|Shroom3|Wipf2|Pdlim2 GO Cellular Components GO:0005912 adherens junction W2 -1.8 8 Itga2|Nectin2|Tns1|Shroom3|Ahi1|Pdlim2|Tns4|Nup214 GO Biological Processes GO:1903829 positive regulation of cellular protein localization W2 -1.8 8 Cep250|Ran|Ccl2|Sorl1|Tert|Pdzk1|Fis1|Edem2 GO Molecular Functions GO:0016829 lyase activity W2 -1.8 6 Bst1|Car8|Me1|Rnase2b|Gadl1|Gldc KEGG Pathway mmu05414 Dilated cardiomyopathy W2 -1.8 4 Itga2|Prkacb|Ryr2|Itga9 GO Biological Processes GO:0071622 regulation of granulocyte chemotaxis W2 -1.8 3 Bst1|Ccl2|Rarres2 Reactome Gene Sets R-MMU-1266738 Developmental Biology W2 -1.8 11 Cxcr4|Col4a1|Krt31|Krt6a|Sprr2d|Sprr2e|Sprr3|Lelp1|Itga9|Rasa1|Lipk GO Molecular Functions GO:0005201 extracellular matrix structural constituent W2 -1.8 5 Col4a1|Igfbp7|Col6a4|Tinagl1|Otol1 GO Biological Processes GO:0002027 regulation of heart rate W2 -1.8 4 Cacna1g|Ryr2|Scn10a|Nppa GO Biological Processes GO:0097035 regulation of membrane lipid distribution W2 -1.8 3 Gba2|Plscr4|Plscr5 GO Cellular Components GO:0005938 cell cortex W2 -1.7 8 Capza3|Fabp1|Myh2|Shroom3|Exoc7|Wipf2|Rhoh|Pdlim2 GO Cellular Components GO:0070161 anchoring junction W2 -1.7 8 Itga2|Nectin2|Tns1|Shroom3|Ahi1|Pdlim2|Tns4|Nup214 GO Biological Processes GO:1904705 regulation of vascular smooth muscle cell proliferation W2 -1.7 3 Dnmt1|Pdcd4|Tert GO Biological Processes GO:1990874 vascular smooth muscle cell proliferation W2 -1.7 3 Dnmt1|Pdcd4|Tert GO Biological Processes GO:1903533 regulation of protein targeting W2 -1.7 3 Ccl2|Pdzk1|Fis1 GO Biological Processes GO:0086001 cardiac muscle cell action potential W2 -1.7 3 Cacna1g|Ryr2|Scn10a GO Biological Processes GO:2001251 negative regulation of chromosome organization W2 -1.7 5 Dnmt1|Ercc1|Rad21|Top2a|Stn1 GO Biological Processes GO:0097530 granulocyte migration W2 -1.7 5 Bst1|Ccl2|Ccl7|Rarres2|Itga9 GO Biological Processes GO:0051196 regulation of coenzyme metabolic process W2 -1.7 3 Fbp1|Me1|Pdk1 GO Biological Processes GO:0030593 neutrophil chemotaxis W2 -1.7 4 Bst1|Ccl2|Ccl7|Itga9 GO Biological Processes GO:0010256 endomembrane system organization W2 -1.7 9 Cxcr4|Myh2|Nectin2|Dym|Fhdc1|Plscr4|Dnajc28|Pheta2|Plscr5 GO Biological Processes GO:0051651 maintenance of location in cell W2 -1.6 4 Bard1|Gaa|Sorl1|Mprip GO Biological Processes GO:0050994 regulation of lipid catabolic process W2 -1.6 3 Fabp1|Sorl1|Rarres2 GO Biological Processes GO:1903827 regulation of cellular protein localization W2 -1.6 11 Bard1|Cep250|Ran|Ccl2|Sorl1|Tert|Gpc6|Pdzk1|Fis1|Edem2|Dclk3 Reactome Gene Sets R-MMU-2029482 Regulation of actin dynamics for phagocytic cup formation W2 -1.6 3 Myh2|Wipf2|Elmo1 GO Molecular Functions GO:0004536 deoxyribonuclease activity W2 -1.6 3 Ercc1|Ercc5|Eri2 GO Biological Processes GO:0061337 cardiac conduction W2 -1.6 3 Cacna1g|Ryr2|Scn10a GO Biological Processes GO:0008544 epidermis development W2 -1.6 8 Gal|Krt6a|Foxc1|Sprr2d|Sprr2e|Sprr3|Lelp1|Lce3e GO Molecular Functions GO:0005539 glycosaminoglycan binding W2 -1.6 6 Ptprf|Ccl2|Ccl7|Pglyrp2|Hapln3|2300002M23Rik GO Biological Processes GO:0006732 coenzyme metabolic process W2 -1.6 8 Dnmt1|Fbp1|Fpgs|Me1|Tdo2|Akr1a1|Qdpr|Pdk1 GO Cellular Components GO:0034704 calcium channel complex W2 -1.6 3 Cacna1g|Ryr2|Catsper4 GO Biological Processes GO:0060047 heart contraction W2 -1.6 6 Cacna1g|Cxcr4|Gaa|Ryr2|Scn10a|Nppa GO Biological Processes GO:0048661 positive regulation of smooth muscle cell proliferation W2 -1.6 4 Dnmt1|Itga2|Tert|Tgm2 GO Biological Processes GO:0060840 artery development W2 -1.6 4 Cxcr4|Nprl3|Foxc1|Notch4 GO Biological Processes GO:0007009 plasma membrane organization W2 -1.6 4 Cxcr4|Myh2|Plscr4|Plscr5 GO Molecular Functions GO:0022836 gated channel activity W2 -1.6 8 Chrng|Cacna1g|Kcnk5|Ryr2|Scn10a|Ttyh2|Tmem150c|Catsper4 GO Biological Processes GO:0051346 negative regulation of hydrolase activity W2 -1.6 9 Serpina6|Cdkn2d|Fabp1|Ptprn2|Sorl1|Mprip|Serpina1f|Nle1|Angptl8 GO Biological Processes GO:0030048 actin filament-based movement W2 -1.6 4 Cacna1g|Myh2|Ryr2|Wipf2 GO Biological Processes GO:0030858 positive regulation of epithelial cell differentiation W2 -1.6 3 Foxc1|Prom1|Ahi1 GO Biological Processes GO:0035904 aorta development W2 -1.5 3 Cxcr4|Nprl3|Notch4 GO Biological Processes GO:1901657 glycosyl compound metabolic process W2 -1.5 4 Ran|Akr1a1|Enpp4|Gba2 GO Biological Processes GO:0048660 regulation of smooth muscle cell proliferation W2 -1.5 5 Dnmt1|Itga2|Pdcd4|Tert|Tgm2 GO Cellular Components GO:0044450 microtubule organizing center part W2 -1.5 5 Cep250|Ran|Top2a|Ahi1|Exoc7 GO Biological Processes GO:0003015 heart process W2 -1.5 6 Cacna1g|Cxcr4|Gaa|Ryr2|Scn10a|Nppa GO Molecular Functions GO:0016788 hydrolase activity, acting on ester bonds W2 -1.5 14 Ercc1|Fbp1|Ptprf|Ptprn2|Ercc5|Rnase2b|Shoc2|Nt5dc2|Eri2|Pan3|Them7|Ddhd1|Lipk|Ptrh1 GO Cellular Components GO:0097733 photoreceptor cell cilium W2 -1.5 4 Cep250|Prom1|Ahi1|Shoc2 GO Molecular Functions GO:0140101 catalytic activity, acting on a tRNA W2 -1.5 4 Farsa|Bcdin3d|Trmt61a|Ptrh1 GO Biological Processes GO:0046324 regulation of glucose import W2 -1.5 3 Tert|Ahi1|Rasa1 GO Biological Processes GO:0048659 smooth muscle cell proliferation W2 -1.5 5 Dnmt1|Itga2|Pdcd4|Tert|Tgm2 GO Cellular Components GO:0005814 centriole W2 -1.5 4 Cep250|Ran|Top2a|Ahi1 GO Cellular Components GO:0097731 9+0 non-motile cilium W2 -1.5 4 Cep250|Prom1|Ahi1|Shoc2 GO Biological Processes GO:0019730 antimicrobial humoral response W2 -1.5 4 Krt6a|Ccl2|Pglyrp2|Rarres2 GO Molecular Functions GO:0043177 organic acid binding W2 -1.5 6 Fabp1|Ryr2|Tdo2|Hapln3|2300002M23Rik|Gldc GO Biological Processes GO:0061982 meiosis I cell cycle process W2 -1.5 4 Ercc1|Rad54l|Top2a|Syce2 GO Biological Processes GO:0050727 regulation of inflammatory response W2 -1.5 8 Bst1|Itga2|Pdcd4|Psmb4|Tgm2|Usp18|Pglyrp2|Nppa GO Biological Processes GO:0032101 regulation of response to external stimulus W2 -1.5 14 Bst1|Capn3|Cxcr4|Itga2|Pdcd4|Psmb4|Ptprf|Ccl2|Tgm2|Usp18|Pglyrp2|Rarres2|Enpp4|Nppa GO Biological Processes GO:0030855 epithelial cell differentiation W2 -1.4 12 Cxcr4|Krt6a|Foxc1|Notch4|Prom1|Sprr2d|Sprr2e|Sprr3|Shroom3|Ahi1|Lelp1|Lce3e GO Biological Processes GO:0033365 protein localization to organelle W2 -1.4 14 Bard1|Cep250|Rad21|Ran|Ryr2|Sorl1|Tert|Gpc6|Ahi1|Fis1|Sprn|Nup214|Szt2|Dclk3 GO Molecular Functions GO:0005518 collagen binding W2 -1.4 3 Itga2|2300002M23Rik|Itga9 GO Biological Processes GO:0055117 regulation of cardiac muscle contraction W2 -1.4 3 Ryr2|Scn10a|Nppa GO Biological Processes GO:0006949 syncytium formation W2 -1.4 3 Ercc1|Nfe2|Ocstamp GO Biological Processes GO:0006855 drug transmembrane transport W2 -1.4 3 Slc47a1|Slc25a18|Oscp1 KEGG Pathway mmu01200 Carbon metabolism W2 -1.4 4 Fbp1|Me1|Tktl2|Gldc GO Biological Processes GO:1990266 neutrophil migration W2 -1.4 4 Bst1|Ccl2|Ccl7|Itga9 GO Biological Processes GO:0033002 muscle cell proliferation W2 -1.4 6 Dnmt1|Itga2|Foxc1|Pdcd4|Tert|Tgm2 GO Biological Processes GO:1901136 carbohydrate derivative catabolic process W2 -1.4 4 Pglyrp2|Edem2|Enpp4|Gba2 GO Molecular Functions GO:0140098 catalytic activity, acting on RNA W2 -1.4 8 Tert|Rnase2b|Farsa|Eri2|Pan3|Bcdin3d|Trmt61a|Ptrh1 GO Biological Processes GO:0045576 mast cell activation W2 -1.4 3 Nectin2|Rhoh|Nppa Reactome Gene Sets R-MMU-216083 Integrin cell surface interactions W2 -1.4 3 Col4a1|Itga2|Itga9 GO Biological Processes GO:0042255 ribosome assembly W2 -1.4 3 Rpsa|Mrps2|Nle1 GO Biological Processes GO:0034762 regulation of transmembrane transport W2 -1.4 11 Capn3|Gal|Ryr2|Scn10a|Ccl2|Tert|Ahi1|Pdzk1|Rasa1|Nppa|Catsper4 GO Biological Processes GO:0008286 insulin receptor signaling pathway W2 -1.4 4 Ptprf|Zfp106|Sorl1|Rarres2 Reactome Gene Sets R-MMU-5576891 Cardiac conduction W2 -1.4 4 Kcnk5|Ryr2|Scn10a|Nppa KEGG Pathway mmu05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC) W2 -1.4 3 Itga2|Ryr2|Itga9 GO Biological Processes GO:1903034 regulation of response to wounding W2 -1.4 5 Capn3|Cxcr4|Ptprf|Ccl2|Enpp4 GO Biological Processes GO:0008016 regulation of heart contraction W2 -1.4 5 Cacna1g|Gaa|Ryr2|Scn10a|Nppa Reactome Gene Sets R-MMU-6781827 Transcription-Coupled Nucleotide Excision Repair (TC-NER) W2 -1.4 3 Ercc1|Cops7a|Zfp830 GO Biological Processes GO:0032386 regulation of intracellular transport W2 -1.4 9 Bard1|Ran|Ccl2|Sorl1|Pdzk1|Fis1|Edem2|Nup214|Nppa GO Biological Processes GO:0010466 negative regulation of peptidase activity W2 -1.4 6 Serpina6|Cdkn2d|Fabp1|Sorl1|Serpina1f|Nle1 GO Biological Processes GO:0051193 regulation of cofactor metabolic process W2 -1.3 3 Fbp1|Me1|Pdk1 GO Biological Processes GO:0032507 maintenance of protein location in cell W2 -1.3 3 Bard1|Sorl1|Mprip GO Cellular Components GO:0000784 nuclear chromosome, telomeric region W2 -1.3 3 Ercc1|Tert|Stn1 GO Biological Processes GO:0046323 glucose import W2 -1.3 3 Tert|Ahi1|Rasa1 GO Biological Processes GO:0046626 regulation of insulin receptor signaling pathway W2 -1.3 3 Ptprf|Sorl1|Rarres2 GO Biological Processes GO:1901606 alpha-amino acid catabolic process W2 -1.3 3 Tdo2|Gldc|Qdpr GO Biological Processes GO:0048844 artery morphogenesis W2 -1.3 3 Nprl3|Foxc1|Notch4 GO Biological Processes GO:1901343 negative regulation of vasculature development W2 -1.3 4 Dnmt1|Foxc1|Pdcd4|Ccl2 GO Biological Processes GO:2001259 positive regulation of cation channel activity W2 -1.3 3 Gal|Ccl2|Nppa GO Biological Processes GO:0032103 positive regulation of response to external stimulus W2 -1.3 7 Cxcr4|Itga2|Pdcd4|Ccl2|Tgm2|Rarres2|Nppa GO Biological Processes GO:0007568 aging W2 -1.3 6 Ercc1|Pdcd4|Rad54l|Tert|Ercc5|Mir877 Reactome Gene Sets R-MMU-2029480 Fcgamma receptor (FCGR) dependent phagocytosis W2 -1.3 3 Myh2|Wipf2|Elmo1 GO Biological Processes GO:0033601 positive regulation of mammary gland epithelial cell proliferation M6 -4.1 4 Rtn4|Rreb1|Kdm5b|Zfp703 GO Molecular Functions GO:0047961 glycine N-acyltransferase activity M6 -3.8 3 Keg1|Glyat|Glyatl3 GO Biological Processes GO:0031663 lipopolysaccharide-mediated signaling pathway M6 -3.5 8 Cd6|Acod1|Lbp|Myd88|Ptpn22|Tnf|Traf6|Trem2 GO Biological Processes GO:0001818 negative regulation of cytokine production M6 -3.2 20 Adcy7|Epha2|Fn1|Hmox1|Il12b|Acod1|Jak3|Lbp|Ptpn22|Tlr6|Tnf|Homer3|Pglyrp2|Rgcc|Traf3ip1|Trem2|Laptm4b|Nploc4|Bank1|Pglyrp4 GO Molecular Functions GO:0070891 lipoteichoic acid binding M6 -3.1 3 Cd6|Lbp|Trem2 GO Biological Processes GO:2000427 positive regulation of apoptotic cell clearance M6 -3.1 3 C2|Ccl2|Trem2 GO Molecular Functions GO:0016775 phosphotransferase activity, nitrogenous group as acceptor M6 -3.1 3 Ckm|Nme2|Map4k4 GO Biological Processes GO:0098581 detection of external biotic stimulus M6 -3.1 5 Lbp|Tlr6|Pglyrp2|Trem2|Pglyrp4 GO Biological Processes GO:0010256 endomembrane system organization M6 -3 26 Col5a1|Nectin2|Spta1|Pacsin2|Stx6|Use1|Pi4k2b|Tbc1d20|Rtn4|Dym|Fam160a2|Sun5|Sec16b|Rab3gap2|Arfgef2|Laptm4b|Nploc4|Xkr7|Tmem201|Tor1aip2|Dnajc28|Ehd2|Syne2|Myo18a|Tlcd2|Baiap3 GO Molecular Functions GO:0001727 lipid kinase activity M6 -2.9 3 Sphk1|Cerk|Cerkl GO Biological Processes GO:2000425 regulation of apoptotic cell clearance M6 -2.9 3 C2|Ccl2|Trem2 KEGG Pathway mmu05168 Herpes simplex infection M6 -2.9 17 Csnk2b|H2-D1|H2-Q1|H2-T3|Ifnar2|Il12b|Irf9|Myd88|Per2|Nectin2|Ccl2|Tnf|Traf6|H2-M10.5|Oas2|Ifit1bl1|H2-Ea-ps GO Biological Processes GO:0001817 regulation of cytokine production M6 -2.9 39 Adcy7|Cd6|Cebpg|Epha2|Fn1|Hmox1|Ifi204|Il12b|Il12rb1|Acod1|Jak3|Arhgef2|Lbp|Myd88|Ptpn22|Ccl2|Sphk1|Tlr6|Tnf|Traf6|Zfp64|Homer3|Agpat1|Pglyrp2|Rgcc|Rtn4|Traf3ip1|Nfam1|Trem2|Trim6|Arfgef2|Laptm4b|Arid5a|Nploc4|Bank1|Psg22|Ltbp1|Pglyrp4|Isg15 GO Biological Processes GO:0009595 detection of biotic stimulus M6 -2.8 5 Lbp|Tlr6|Pglyrp2|Trem2|Pglyrp4 GO Biological Processes GO:0042059 negative regulation of epidermal growth factor receptor signaling pathway M6 -2.8 5 Ptprf|Dusp3|Itga1|Chmp6|Gprc5a GO Biological Processes GO:0001816 cytokine production M6 -2.8 42 Adcy7|Cd6|Cebpg|Epha2|Fn1|Hmox1|Ifi204|Il12b|Il12rb1|Acod1|Irf9|Jak3|Arhgef2|Lbp|Myd88|Ptpn22|Ccl2|Sphk1|Tlr6|Tnf|Traf6|Zfp64|Homer3|Tcirg1|Agpat1|Pglyrp2|Rgcc|Rtn4|Traf3ip1|Nfam1|Trem2|Trim6|Arfgef2|Laptm4b|Il25|Arid5a|Nploc4|Bank1|Psg22|Ltbp1|Pglyrp4|Isg15 KEGG Pathway mmu05332 Graft-versus-host disease M6 -2.8 8 H2-D1|H2-Q1|H2-T3|Klra7|Klra9|Tnf|H2-M10.5|H2-Ea-ps Reactome Gene Sets R-MMU-193704 p75 NTR receptor-mediated signalling M6 -2.7 9 Arhgef2|Myd88|Traf6|Uba52|Rtn4|Arhgef10l|Arhgef17|Arhgef19|Prex1 GO Biological Processes GO:1901185 negative regulation of ERBB signaling pathway M6 -2.7 5 Ptprf|Dusp3|Itga1|Chmp6|Gprc5a GO Biological Processes GO:0070886 positive regulation of calcineurin-NFAT signaling cascade M6 -2.6 4 Tnf|Cherp|Nrg1|Akap6 GO Biological Processes GO:0032740 positive regulation of interleukin-17 production M6 -2.6 4 Il12b|Myd88|Sphk1|Arid5a GO Biological Processes GO:0106058 positive regulation of calcineurin-mediated signaling M6 -2.6 4 Tnf|Cherp|Nrg1|Akap6 GO Molecular Functions GO:1990782 protein tyrosine kinase binding M6 -2.6 10 Angpt4|Dok2|Pik3r2|Ptpn22|Ptprf|Dusp3|Trem2|Trim6|Nrg1|Bank1 KEGG Pathway mmu05142 Chagas disease (American trypanosomiasis) M6 -2.6 10 Gna14|Il12b|Myd88|Pik3cd|Pik3r2|Plcb2|Ccl2|Tlr6|Tnf|Traf6 GO Biological Processes GO:0050848 regulation of calcium-mediated signaling M6 -2.6 10 Bst1|Tnf|Zap70|Homer3|Cherp|Selenon|Trem2|Sri|Nrg1|Akap6 KEGG Pathway mmu04940 Type I diabetes mellitus M6 -2.6 8 H2-D1|H2-Q1|H2-T3|Il12b|Ptprn2|Tnf|H2-M10.5|H2-Ea-ps GO Cellular Components GO:0120103 centriolar subdistal appendage M6 -2.5 3 Nin|Ccdc68|Cep170 Reactome Gene Sets R-MMU-110357 Displacement of DNA glycosylase by APEX1 M6 -2.5 3 Mbd4|Ogg1|Mpg GO Cellular Components GO:0005771 multivesicular body M6 -2.5 6 Cd79a|Cst3|Cst7|Nsg2|Sftpc|Laptm4b GO Biological Processes GO:0002711 positive regulation of T cell mediated immunity M6 -2.5 8 H2-D1|H2-Q1|H2-T3|Il12b|Nectin2|Traf6|Arid5a|H2-M10.5 GO Biological Processes GO:0009895 negative regulation of catabolic process M6 -2.5 20 Cst3|Fbp1|Hmox1|Myd88|Ptpn22|Rps7|Tnf|Ube2g2|Pik3cg|Pdcl3|Dapl1|Trim39|Cdk5rap3|Trem2|Laptm4b|Trim40|Lzts1|Nrg1|Thrap3|Lrig2 GO Biological Processes GO:0018108 peptidyl-tyrosine phosphorylation M6 -2.4 21 Angpt4|Blk|Bst1|Cntn1|Crlf1|Hpx|Il12b|Il12rb1|Jak3|Arhgef2|Nf2|Ptpn22|Tnf|Zap70|Pdcl3|Traf3ip1|Trem2|Chmp6|Nrg1|Gprc5a|Bank1 GO Biological Processes GO:0002699 positive regulation of immune effector process M6 -2.4 18 H2-D1|H2-Q1|H2-T3|Hmox1|Hpx|Il12b|Lbp|Ptpn22|Nectin2|Ccl2|Tnf|Traf6|Rtn4|Trim6|Arid5a|H2-M10.5|Myo18a|H60c KEGG Pathway mmu04612 Antigen processing and presentation M6 -2.4 9 Hspa5|H2-D1|H2-Q1|H2-T3|Hspa4|Rfxank|Tnf|H2-M10.5|H2-Ea-ps GO Biological Processes GO:0018212 peptidyl-tyrosine modification M6 -2.4 21 Angpt4|Blk|Bst1|Cntn1|Crlf1|Hpx|Il12b|Il12rb1|Jak3|Arhgef2|Nf2|Ptpn22|Tnf|Zap70|Pdcl3|Traf3ip1|Trem2|Chmp6|Nrg1|Gprc5a|Bank1 GO Biological Processes GO:0033599 regulation of mammary gland epithelial cell proliferation M6 -2.4 4 Rtn4|Rreb1|Kdm5b|Zfp703 KEGG Pathway mmu00030 Pentose phosphate pathway M6 -2.3 5 Fbp1|Rpia|Pgls|Tktl2|Prps1l1 GO Biological Processes GO:0048668 collateral sprouting M6 -2.3 5 Cobl|Dvl1|Nin|Ulk1|Rtn4 Reactome Gene Sets R-MMU-8957275 Post-translational protein phosphorylation M6 -2.3 10 C4b|Cst3|Fn1|Igfbp7|Mxra8|Mepe|Ckap4|Ltbp1|Ano8|Apol7e GO Biological Processes GO:0033598 mammary gland epithelial cell proliferation M6 -2.3 5 Epha2|Rtn4|Rreb1|Kdm5b|Zfp703 GO Biological Processes GO:0018149 peptide cross-linking M6 -2.3 7 Fn1|Sprr2d|Sprr2e|Sprr3|Lelp1|Tgm6|Tgm4 GO Biological Processes GO:0032490 detection of molecule of bacterial origin M6 -2.3 3 Lbp|Tlr6|Trem2 GO Biological Processes GO:0002709 regulation of T cell mediated immunity M6 -2.3 9 Dpp4|H2-D1|H2-Q1|H2-T3|Il12b|Nectin2|Traf6|Arid5a|H2-M10.5 GO Biological Processes GO:0031330 negative regulation of cellular catabolic process M6 -2.3 17 Cst3|Fbp1|Hmox1|Myd88|Ptpn22|Rps7|Ube2g2|Pik3cg|Pdcl3|Dapl1|Trim39|Cdk5rap3|Trem2|Laptm4b|Lzts1|Thrap3|Lrig2 GO Biological Processes GO:0050850 positive regulation of calcium-mediated signaling M6 -2.2 6 Tnf|Zap70|Cherp|Trem2|Nrg1|Akap6 GO Biological Processes GO:0043408 regulation of MAPK cascade M6 -2.2 39 Acta2|Axin1|Dok2|Epha2|Fn1|Gcnt2|Mid1|Myd88|Nf2|Pik3r2|Ppef2|Ptpn22|Ccl2|Ccl7|Sphk1|Tlr6|Tnf|Traf6|Xdh|Gdf15|Map3k5|Cops5|Map4k4|Pik3cg|Lpar2|Fam83d|Dusp3|Unc5cl|Cdk5rap3|Tnxb|Trem2|Maged1|Cavin3|Itga1|Spred2|Ankrd26|Bank1|Taok3|Nek10 GO Molecular Functions GO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds M6 -2.2 4 Bst1|Mbd4|Ogg1|Mpg KEGG Pathway mmu05330 Allograft rejection M6 -2.2 7 H2-D1|H2-Q1|H2-T3|Il12b|Tnf|H2-M10.5|H2-Ea-ps GO Biological Processes GO:0002697 regulation of immune effector process M6 -2.2 25 Dpp4|H2-D1|H2-Q1|H2-T3|Hmox1|Hpx|Il12b|Il12rb1|Jak3|Lbp|Ptpn22|Nectin2|Ccl2|Tnf|Traf6|Pglyrp2|Rtn4|Traf3ip1|Trim6|Arid5a|Nploc4|H2-M10.5|Myo18a|Pglyrp4|H60c GO Biological Processes GO:0001916 positive regulation of T cell mediated cytotoxicity M6 -2.2 6 H2-D1|H2-Q1|H2-T3|Il12b|Nectin2|H2-M10.5 GO Biological Processes GO:0031424 keratinization M6 -2.2 5 Sprr2d|Sprr2e|Sprr3|Kazn|Gprc5d GO Molecular Functions GO:0005539 glycosaminoglycan binding M6 -2.2 15 Col5a1|Ncan|Fn1|Igfals|Mmp7|Ptprf|Rpl22|Ccl2|Ccl7|Pglyrp2|Hapln3|Tnxb|Trem2|Hapln4|Pglyrp4 Reactome Gene Sets R-MMU-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Bi M6 -2.2 10 C4b|Cst3|Fn1|Igfbp7|Mxra8|Mepe|Ckap4|Ltbp1|Ano8|Apol7e GO Molecular Functions GO:0019901 protein kinase binding M6 -2.2 38 Acta2|Angpt4|Axin1|Ccnd3|Cd6|Dok2|Dvl1|Gria2|Ifnar2|Pik3r2|Ppef2|Ptpn22|Ptprf|Rbbp6|Rps18|Rps7|Srebf1|Tesk1|Traf6|Ulk1|Wars|Ldb3|Map3k5|Rgcc|Telo2|Fam83d|Dusp3|Bora|Cdk5rap3|Trem2|Tex14|Trim6|Cavin3|Inka2|Spred2|Nrg1|Tpcn2|Bank1 KEGG Pathway mmu_M00004 Pentose phosphate pathway (Pentose phosphate cycle) M6 -2.1 3 Rpia|Pgls|Tktl2 KEGG Pathway M00004 Pentose phosphate pathway (Pentose phosphate cycle) M6 -2.1 3 Rpia|Pgls|Tktl2 GO Molecular Functions GO:0003951 NAD+ kinase activity M6 -2.1 3 Sphk1|Nadk|Cerk Reactome Gene Sets R-MMU-209543 p75NTR recruits signalling complexes M6 -2.1 3 Myd88|Traf6|Uba52 KEGG Pathway mmu04620 Toll-like receptor signaling pathway M6 -2.1 9 Ifnar2|Il12b|Lbp|Myd88|Pik3cd|Pik3r2|Tlr6|Tnf|Traf6 KEGG Pathway mmu05340 Primary immunodeficiency M6 -2.1 5 Cd79a|Jak3|Rfxank|Zap70|Tnfrsf13b KEGG Pathway mmu05162 Measles M6 -2.1 11 Ccnd3|Csnk2b|Ifnar2|Il12b|Irf9|Jak3|Myd88|Pik3cd|Pik3r2|Traf6|Oas2 GO Biological Processes GO:1901184 regulation of ERBB signaling pathway M6 -2.1 7 Ptprf|Rtn4|Dusp3|Mvb12a|Itga1|Chmp6|Gprc5a GO Biological Processes GO:0000165 MAPK cascade M6 -2.1 41 Acta2|Axin1|Dok2|Epha2|Fn1|Gcnt2|Mid1|Myd88|Nf2|Pik3r2|Ppef2|Ptpn22|Ccl2|Ccl7|Sphk1|Tlr6|Tnf|Traf6|Xdh|Gdf15|Map3k5|Cops5|Map4k4|Pik3cg|Lpar2|Fam83d|Dusp3|Unc5cl|Cdk5rap3|Tnxb|Trem2|Plvap|Maged1|Cavin3|Itga1|Spred2|Nrg1|Ankrd26|Bank1|Taok3|Nek10 GO Biological Processes GO:0031343 positive regulation of cell killing M6 -2.1 9 H2-D1|H2-Q1|H2-T3|Il12b|Nectin2|Ccl2|H2-M10.5|Pglyrp4|H60c GO Molecular Functions GO:0005509 calcium ion binding M6 -2.1 33 Ncan|Dst|Grin1|Guca1a|Myl7|Nin|Notch4|Plcb2|Ppef2|Spta1|Tnnt2|Tpd52|Pla2g2e|Pla2g2f|Cdhr3|Efcab3|Tbc1d9|Calr3|Col20a1|C2cd5|Selenon|Creld2|Kcnip2|Nkd1|Myl9|Sri|Lpcat1|Dsg1c|Ehd2|Capn11|Ltbp1|Calm5|Baiap3 GO Biological Processes GO:0032872 regulation of stress-activated MAPK cascade M6 -2.1 16 Axin1|Mid1|Myd88|Ptpn22|Sphk1|Tlr6|Tnf|Traf6|Xdh|Map3k5|Cops5|Map4k4|Dusp3|Unc5cl|Tnxb|Taok3 Reactome Gene Sets R-MMU-204998 Cell death signalling via NRAGE, NRIF and NADE M6 -2.1 7 Arhgef2|Traf6|Uba52|Arhgef10l|Arhgef17|Arhgef19|Prex1 GO Biological Processes GO:0072643 interferon-gamma secretion M6 -2.1 4 Ptpn22|Tcirg1|Arid5a|Isg15 GO Biological Processes GO:0070302 regulation of stress-activated protein kinase signaling cascade M6 -2.1 16 Axin1|Mid1|Myd88|Ptpn22|Sphk1|Tlr6|Tnf|Traf6|Xdh|Map3k5|Cops5|Map4k4|Dusp3|Unc5cl|Tnxb|Taok3 KEGG Pathway mmu00230 Purine metabolism M6 -2 13 Adcy7|Entpd6|Nme2|Pde1a|Pde9a|Pklr|Xdh|Gmpr|Prps1l1|Allc|Atic|Enpp4|Gucy1b2 GO Molecular Functions GO:0019104 DNA N-glycosylase activity M6 -2 3 Mbd4|Ogg1|Mpg GO Biological Processes GO:0032026 response to magnesium ion M6 -2 3 Entpd6|Fbp1|Kcnj1 GO Biological Processes GO:0002824 positive regulation of adaptive immune response based on somatic recombination of immune receptors b M6 -2 11 H2-D1|H2-Q1|H2-T3|Hpx|Il12b|Il12rb1|Nectin2|Tnf|Traf6|Arid5a|H2-M10.5 GO Cellular Components GO:0005815 microtubule organizing center M6 -2 35 Cep131|Birc6|Dync1h1|Mak|Nin|Procr|Rbbp6|Rps7|Tcp10b|Wrn|Tekt2|Nubp2|Cep63|Ddah2|Exoc7|Keg1|Rgcc|Ckap2l|Mvb12a|Kif2c|Atp6v1d|Traf3ip1|Map10|C2cd5|Cdk5rap3|Arfgef2|Ift140|Crocc|Tmem201|Ankrd26|Harbi1|Nphp4|Syne2|Ccdc68|Cep170 GO Biological Processes GO:0006855 drug transmembrane transport M6 -2 7 Per2|Abcb4|Slc1a2|Slc7a5|Tnf|Oscp1|Slc47a2 GO Biological Processes GO:0001912 positive regulation of leukocyte mediated cytotoxicity M6 -2 8 H2-D1|H2-Q1|H2-T3|Il12b|Nectin2|Ccl2|H2-M10.5|H60c GO Biological Processes GO:0050730 regulation of peptidyl-tyrosine phosphorylation M6 -2 17 Angpt4|Bst1|Cntn1|Crlf1|Hpx|Il12b|Arhgef2|Nf2|Ptpn22|Tnf|Pdcl3|Traf3ip1|Trem2|Chmp6|Nrg1|Gprc5a|Bank1 GO Biological Processes GO:0032609 interferon-gamma production M6 -2 10 Cebpg|Il12b|Il12rb1|Ptpn22|Tnf|Tcirg1|Pglyrp2|Arid5a|Pglyrp4|Isg15 Reactome Gene Sets R-MMU-73887 Death Receptor Signalling M6 -2 10 Arhgef2|Myd88|Tnf|Traf6|Uba52|Rtn4|Arhgef10l|Arhgef17|Arhgef19|Prex1 GO Biological Processes GO:0001914 regulation of T cell mediated cytotoxicity M6 -2 6 H2-D1|H2-Q1|H2-T3|Il12b|Nectin2|H2-M10.5 GO Biological Processes GO:0043030 regulation of macrophage activation M6 -2 6 Cst7|Lbp|Sphk1|Tlr6|Trem2|Myo18a GO Biological Processes GO:0009267 cellular response to starvation M6 -2 11 Hspa5|Nprl3|Srebf1|Ulk1|Wrn|Map3k5|Slc39a4|Dapl1|Rrp8|Szt2|Tnrc6a GO Molecular Functions GO:0005089 Rho guanyl-nucleotide exchange factor activity M6 -2 7 Arhgef2|Arhgef10l|Arhgef17|Dock10|Arhgef19|Farp1|Prex1 GO Biological Processes GO:0051090 regulation of DNA-binding transcription factor activity M6 -2 23 Cebpg|Hmox1|Acod1|Arhgef2|Myd88|Ptgis|Sphk1|Trim21|Tlr6|Tnf|Traf6|Cops5|Rgcc|Nfam1|Adgrf1|Cdk5rap3|Sri|Card14|Trim40|Trim31|Pprc1|Camk1d|Nwd1 GO Biological Processes GO:0021932 hindbrain radial glia guided cell migration M6 -2 3 Ulk1|Rere|Rbfox2 GO Biological Processes GO:0098712 L-glutamate import across plasma membrane M6 -2 3 Per2|Slc1a2|Tnf GO Biological Processes GO:0010457 centriole-centriole cohesion M6 -2 3 Nin|Crocc|Syne2 GO Molecular Functions GO:0052742 phosphatidylinositol kinase activity M6 -2 3 Pik3cd|Pik3cg|Pi4k2b GO Biological Processes GO:0002708 positive regulation of lymphocyte mediated immunity M6 -1.9 11 H2-D1|H2-Q1|H2-T3|Hpx|Il12b|Nectin2|Tnf|Traf6|Arid5a|H2-M10.5|H60c GO Molecular Functions GO:0009975 cyclase activity M6 -1.9 4 Adcy7|Bst1|Dglucy|Gucy1b2 GO Biological Processes GO:0106056 regulation of calcineurin-mediated signaling M6 -1.9 5 Tnf|Homer3|Cherp|Nrg1|Akap6 GO Biological Processes GO:0070884 regulation of calcineurin-NFAT signaling cascade M6 -1.9 5 Tnf|Homer3|Cherp|Nrg1|Akap6 GO Biological Processes GO:0045185 maintenance of protein location M6 -1.9 9 Bard1|Hspa5|Rangap1|Taf8|Sun5|Sri|Tnrc6a|Ltbp1|Syne2 KEGG Pathway mmu04310 Wnt signaling pathway M6 -1.9 11 Axin1|Ccnd3|Csnk2b|Dvl1|Mmp7|Plcb2|Tcf7|Wnt8b|Nkd1|Vangl1|Gm5415 GO Biological Processes GO:0046578 regulation of Ras protein signal transduction M6 -1.9 15 F2rl2|Fbp1|Arhgef2|Map4k4|Lpar2|Rtn4|Arhgef10l|Arfgef2|Arhgef17|Nrg1|Arhgef19|Farp1|Kank2|Prex1|Gpr4 GO Biological Processes GO:0002821 positive regulation of adaptive immune response M6 -1.9 11 H2-D1|H2-Q1|H2-T3|Hpx|Il12b|Il12rb1|Nectin2|Tnf|Traf6|Arid5a|H2-M10.5 GO Biological Processes GO:1901018 positive regulation of potassium ion transmembrane transporter activity M6 -1.9 4 Gal|Trem2|Akap6|Lrrc38 GO Biological Processes GO:0042594 response to starvation M6 -1.9 12 Hspa5|Nprl3|Srebf1|Ulk1|Wrn|Map3k5|Slc39a4|Dapl1|Rrp8|Szt2|Tnrc6a|Lrp11 Reactome Gene Sets R-MMU-194840 Rho GTPase cycle M6 -1.9 10 Arhgef2|Pik3r2|Arhgap17|Arhgef10l|Arhgap8|Arhgap15|Gmip|Arhgef17|Arhgef19|Prex1 GO Biological Processes GO:0001819 positive regulation of cytokine production M6 -1.9 25 Cd6|Cebpg|Ifi204|Il12b|Il12rb1|Arhgef2|Lbp|Myd88|Ptpn22|Ccl2|Sphk1|Tlr6|Tnf|Traf6|Zfp64|Agpat1|Rgcc|Rtn4|Nfam1|Trem2|Trim6|Arfgef2|Arid5a|Nploc4|Psg22 GO Biological Processes GO:0002819 regulation of adaptive immune response M6 -1.9 14 Adcy7|Dpp4|H2-D1|H2-Q1|H2-T3|Hpx|Il12b|Il12rb1|Jak3|Nectin2|Tnf|Traf6|Arid5a|H2-M10.5 Reactome Gene Sets R-MMU-71336 Pentose phosphate pathway M6 -1.9 3 Rpia|Pgls|Prps1l1 Reactome Gene Sets R-MMU-193639 p75NTR signals via NF-kB M6 -1.9 3 Myd88|Traf6|Uba52 GO Biological Processes GO:1903978 regulation of microglial cell activation M6 -1.9 3 Cst7|Sphk1|Trem2 GO Biological Processes GO:0051938 L-glutamate import M6 -1.9 3 Per2|Slc1a2|Tnf GO Biological Processes GO:0070307 lens fiber cell development M6 -1.9 3 Bfsp1|Epha2|Tbc1d20 GO Biological Processes GO:1903818 positive regulation of voltage-gated potassium channel activity M6 -1.9 3 Trem2|Akap6|Lrrc38 KEGG Pathway mmu05164 Influenza A M6 -1.9 12 Ifnar2|Il12b|Irf9|Myd88|Pik3cd|Pik3r2|Ccl2|Tnf|Tmprss4|Tmprss13|Oas2|H2-Ea-ps GO Biological Processes GO:0032649 regulation of interferon-gamma production M6 -1.9 9 Cebpg|Il12b|Il12rb1|Ptpn22|Tnf|Pglyrp2|Arid5a|Pglyrp4|Isg15 GO Biological Processes GO:0019722 calcium-mediated signaling M6 -1.9 14 Bst1|Sphk1|Tnf|Zap70|Homer3|Cherp|Treml1|Selenon|Trem2|Sri|Nrg1|Tpcn2|Akap6|Calm5 GO Biological Processes GO:0042177 negative regulation of protein catabolic process M6 -1.9 10 Cst3|Rps7|Ube2g2|Pdcl3|Trim39|Cdk5rap3|Laptm4b|Trim40|Nrg1|Lrig2 GO Biological Processes GO:0034198 cellular response to amino acid starvation M6 -1.8 5 Nprl3|Ulk1|Map3k5|Dapl1|Szt2 GO Biological Processes GO:1902622 regulation of neutrophil migration M6 -1.8 5 Bst1|Lbp|Myd88|Rtn4|Camk1d KEGG Pathway mmu05133 Pertussis M6 -1.8 7 C2|C4b|Il12b|Myd88|Tnf|Traf6|Calm5 GO Biological Processes GO:0007260 tyrosine phosphorylation of STAT protein M6 -1.8 7 Crlf1|Hpx|Il12b|Jak3|Nf2|Tnf|Traf3ip1 GO Biological Processes GO:0032507 maintenance of protein location in cell M6 -1.8 7 Bard1|Hspa5|Rangap1|Taf8|Sun5|Tnrc6a|Syne2 GO Molecular Functions GO:0008509 anion transmembrane transporter activity M6 -1.8 19 Clcnka|Slc1a2|Slc23a1|Slc34a2|Slc4a3|Slc7a5|Slc7a7|Slc52a2|Clcnkb|Slco1c1|Pacc1|Slc52a3|Slc35b2|Slc35a5|Slco3a1|Slc5a5|Slco5a1|Slc26a11|Ano8 GO Biological Processes GO:0046328 regulation of JNK cascade M6 -1.8 13 Axin1|Myd88|Ptpn22|Tlr6|Tnf|Traf6|Map3k5|Cops5|Map4k4|Dusp3|Unc5cl|Tnxb|Taok3 GO Biological Processes GO:1901381 positive regulation of potassium ion transmembrane transport M6 -1.8 5 Gal|Kcnip2|Trem2|Akap6|Lrrc38 GO Biological Processes GO:0001913 T cell mediated cytotoxicity M6 -1.8 7 H2-D1|H2-Q1|H2-T3|Il12b|Nectin2|H2-M10.5|H60c GO Molecular Functions GO:0001540 amyloid-beta binding M6 -1.8 6 Apbb1|Cst3|Gria2|Grin1|Pirb|Trem2 GO Biological Processes GO:0008347 glial cell migration M6 -1.8 6 Fn1|Grin1|Ccl2|Rtn4|Trem2|Syne2 GO Biological Processes GO:0002822 regulation of adaptive immune response based on somatic recombination of immune receptors built from M6 -1.8 13 Dpp4|H2-D1|H2-Q1|H2-T3|Hpx|Il12b|Il12rb1|Jak3|Nectin2|Tnf|Traf6|Arid5a|H2-M10.5 GO Cellular Components GO:0048471 perinuclear region of cytoplasm M6 -1.8 33 Prdx6|Apbb1|Axin1|Cobl|Cst3|Dst|Hmox1|Insl3|M6pr|Myo5b|Nf2|Nme2|Per2|Procr|Ptpn22|Rangap1|Ccl2|Sprr3|Tg|Tpd52|Traf6|Cops5|Cherp|Stx6|Taf8|Epn3|Cerkl|Tnrc6a|Akap6|Oas2|Ehd2|Ltbp1|Prex1 Reactome Gene Sets R-MMU-381753 Olfactory Signaling Pathway M6 -1.8 21 Olfr17|Olfr68|Rtp3|Olfr222|Olfr1034|Olfr420|Olfr657|Olfr554|Olfr692|Olfr677|Olfr698|Olfr661|Olfr556|Olfr473|Olfr640|Olfr589|Olfr641|Olfr552|Olfr555|Olfr681|Olfr151 GO Biological Processes GO:0060314 regulation of ryanodine-sensitive calcium-release channel activity M6 -1.8 3 Selenon|Sri|Akap6 Reactome Gene Sets R-MMU-447115 Interleukin-12 family signaling M6 -1.8 3 Crlf1|Il12b|Il12rb1 GO Molecular Functions GO:0042834 peptidoglycan binding M6 -1.8 3 Pglyrp2|Trem2|Pglyrp4 GO Biological Processes GO:0098543 detection of other organism M6 -1.8 3 Tlr6|Pglyrp2|Pglyrp4 Reactome Gene Sets R-MMU-211979 Eicosanoids M6 -1.8 3 Cyp4a12b|Ptgis|Cyp4f15 GO Biological Processes GO:0016045 detection of bacterium M6 -1.8 3 Tlr6|Pglyrp2|Pglyrp4 GO Biological Processes GO:0031329 regulation of cellular catabolic process M6 -1.8 35 Axin1|Cst3|Dvl1|Fabp1|Fbp1|Hmox1|Eif6|Nprl3|Myd88|Pik3r2|Ptpn22|Rps7|Srebf1|Trim21|Tfeb|Tnf|Ube2g2|Ulk1|Pik3cg|Pdcl3|Ankib1|Dapl1|Trim39|Cdk5rap3|Trem2|Rab3gap2|Laptm4b|Lzts1|Bag2|Dlgap1|Thrap3|Tnrc6a|Tpcn2|Lrig2|Tmem150b GO Biological Processes GO:0002230 positive regulation of defense response to virus by host M6 -1.8 4 Il12b|Il12rb1|Ptpn22|Trim6 Reactome Gene Sets R-MMU-445355 Smooth Muscle Contraction M6 -1.8 4 Acta2|Myl7|Myl9|Itga1 GO Biological Processes GO:0050766 positive regulation of phagocytosis M6 -1.8 7 C2|Lbp|Ccl2|Tnf|Trem2|Camk1d|Myo18a GO Cellular Components GO:0005901 caveola M6 -1.8 8 Hmox1|Ptgis|Tfpi|Pacsin2|Plvap|Cavin3|Akap6|Ehd2 GO Biological Processes GO:0043506 regulation of JUN kinase activity M6 -1.8 8 Axin1|Ptpn22|Tlr6|Tnf|Traf6|Map3k5|Tnxb|Taok3 GO Biological Processes GO:0001704 formation of primary germ layer M6 -1.8 8 Axin1|Col5a1|Epha2|Fn1|Nf2|Pou5f1|Atoh8|Arid1a GO Cellular Components GO:0016459 myosin complex M6 -1.8 6 Myl7|Myo15|Myo5b|Myo7b|Myl9|Myo18a GO Biological Processes GO:0032874 positive regulation of stress-activated MAPK cascade M6 -1.8 12 Axin1|Mid1|Myd88|Sphk1|Tlr6|Tnf|Traf6|Xdh|Map3k5|Map4k4|Unc5cl|Taok3 KEGG Pathway mmu04150 mTOR signaling pathway M6 -1.8 11 Dvl1|Nprl3|Pik3cd|Pik3r2|Slc7a5|Tnf|Ulk1|Wnt8b|Telo2|Atp6v1d|Tti1 GO Biological Processes GO:0034340 response to type I interferon M6 -1.8 5 Ifnar2|Myd88|Trim6|Oas2|Isg15 GO Biological Processes GO:0051898 negative regulation of protein kinase B signaling M6 -1.8 5 Epha2|Pou5f1|Xdh|Cavin3|Bank1 GO Molecular Functions GO:0019207 kinase regulator activity M6 -1.8 13 Angpt4|Ccnd3|Csnk2b|Pik3r2|Wars|Tcl1b5|Ccnl2|Rgcc|Gprc5d|Inka2|Spred2|Nrg1|Gprc5a GO Cellular Components GO:0005813 centrosome M6 -1.8 27 Cep131|Dync1h1|Mak|Nin|Procr|Rbbp6|Rps7|Wrn|Nubp2|Cep63|Exoc7|Keg1|Rgcc|Ckap2l|Mvb12a|Kif2c|Atp6v1d|Traf3ip1|Map10|Cdk5rap3|Ift140|Crocc|Tmem201|Ankrd26|Nphp4|Syne2|Cep170 GO Biological Processes GO:0070304 positive regulation of stress-activated protein kinase signaling cascade M6 -1.8 12 Axin1|Mid1|Myd88|Sphk1|Tlr6|Tnf|Traf6|Xdh|Map3k5|Map4k4|Unc5cl|Taok3 GO Biological Processes GO:0032675 regulation of interleukin-6 production M6 -1.7 11 Arhgef2|Lbp|Myd88|Ptpn22|Tlr6|Tnf|Traf6|Zfp64|Trem2|Arid5a|Bank1 GO Biological Processes GO:0002260 lymphocyte homeostasis M6 -1.7 7 Jak3|Pik3cd|Pirb|Spta1|Tcirg1|Tnfrsf13b|Dock10 KEGG Pathway mmu04970 Salivary secretion M6 -1.7 7 Adcy7|Bst1|Chrm3|Cst3|Plcb2|Gucy1b2|Calm5 GO Biological Processes GO:0042058 regulation of epidermal growth factor receptor signaling pathway M6 -1.7 6 Ptprf|Dusp3|Mvb12a|Itga1|Chmp6|Gprc5a GO Biological Processes GO:0035023 regulation of Rho protein signal transduction M6 -1.7 10 F2rl2|Arhgef2|Lpar2|Arhgef10l|Arhgef17|Arhgef19|Farp1|Kank2|Prex1|Gpr4 GO Biological Processes GO:0051896 regulation of protein kinase B signaling M6 -1.7 11 Epha2|Gcnt2|Pou5f1|Tnf|Xdh|Gdf15|Pik3cg|Rtn4|Cavin3|Nrg1|Bank1 GO Biological Processes GO:0051186 cofactor metabolic process M6 -1.7 27 Prdx6|Fbp1|Fdxr|Fpgs|Got1|Gsr|Hbb-y|Hebp1|Hmox1|Hpx|Eif6|Ldhb|Pemt|Pklr|Rpia|Spta1|Nubp2|Pgls|Coq8a|Acss1|Glyat|Atic|Nadk|Dhtkd1|Nmrk1|Pdk1|Far2 GO Biological Processes GO:0001774 microglial cell activation M6 -1.7 5 Cst7|Sphk1|Tlr6|Tnf|Trem2 GO Biological Processes GO:0002269 leukocyte activation involved in inflammatory response M6 -1.7 5 Cst7|Sphk1|Tlr6|Tnf|Trem2 GO Biological Processes GO:0070306 lens fiber cell differentiation M6 -1.7 4 Bfsp1|Epha2|Nf2|Tbc1d20 Reactome Gene Sets R-MMU-196807 Nicotinate metabolism M6 -1.7 4 Bst1|Ptgis|Nadk|Nmrk1 Reactome Gene Sets R-MMU-917729 Endosomal Sorting Complex Required For Transport (ESCRT) M6 -1.7 4 Uba52|Mvb12a|Vps37c|Chmp6 GO Biological Processes GO:0002825 regulation of T-helper 1 type immune response M6 -1.7 4 Il12b|Il12rb1|Jak3|Arid5a Reactome Gene Sets R-MMU-196849 Metabolism of water-soluble vitamins and cofactors M6 -1.7 9 Bst1|Fpgs|Ptgis|Slc23a1|Slc52a2|Pccb|Slc52a3|Nadk|Nmrk1 Reactome Gene Sets R-MMU-397014 Muscle contraction M6 -1.7 12 Acta2|Kcnk5|Myl7|Scn10a|Abcc9|Tnnt2|Corin|Scn2b|Kcnip2|Myl9|Sri|Itga1 GO Biological Processes GO:0045410 positive regulation of interleukin-6 biosynthetic process M6 -1.7 3 Tlr6|Tnf|Traf6 GO Molecular Functions GO:0015347 sodium-independent organic anion transmembrane transporter activity M6 -1.7 3 Slco1c1|Slco3a1|Slco5a1 Reactome Gene Sets R-MMU-210993 Tie2 Signaling M6 -1.7 3 Angpt4|Dok2|Pik3r2 GO Biological Processes GO:0071786 endoplasmic reticulum tubular network organization M6 -1.7 3 Use1|Rtn4|Rab3gap2 GO Biological Processes GO:0002922 positive regulation of humoral immune response M6 -1.7 3 Hpx|Acod1|Tnf Reactome Gene Sets R-MMU-1482925 Acyl chain remodelling of PG M6 -1.7 3 Pla2g2e|Pla2g2f|Lpcat1 GO Biological Processes GO:0070571 negative regulation of neuron projection regeneration M6 -1.7 3 Map4k4|Rtn4|Lrig2 GO Biological Processes GO:0050671 positive regulation of lymphocyte proliferation M6 -1.7 10 Bst1|Cd6|Il12b|Il12rb1|Jak3|Myd88|Ptpn22|Spta1|Traf6|Zap70 GO Biological Processes GO:0032760 positive regulation of tumor necrosis factor production M6 -1.7 8 Il12b|Arhgef2|Lbp|Myd88|Ccl2|Zfp64|Arfgef2|Arid5a GO Biological Processes GO:0042102 positive regulation of T cell proliferation M6 -1.7 8 Cd6|Il12b|Il12rb1|Jak3|Ptpn22|Spta1|Traf6|Zap70 GO Biological Processes GO:0051403 stress-activated MAPK cascade M6 -1.7 16 Axin1|Mid1|Myd88|Ptpn22|Sphk1|Tlr6|Tnf|Traf6|Xdh|Map3k5|Cops5|Map4k4|Dusp3|Unc5cl|Tnxb|Taok3 GO Molecular Functions GO:0051879 Hsp90 protein binding M6 -1.7 5 Cyp2b10|Ppef2|Ulk1|Telo2|Unc45a GO Biological Processes GO:1990928 response to amino acid starvation M6 -1.7 5 Nprl3|Ulk1|Map3k5|Dapl1|Szt2 GO Biological Processes GO:0098754 detoxification M6 -1.7 5 Prdx6|Mt4|Tnf|Acaa1a|Szt2 GO Biological Processes GO:0010799 regulation of peptidyl-threonine phosphorylation M6 -1.7 5 Axin1|Ppef2|Sphk1|Trim6|Spred2 KEGG Pathway mmu05152 Tuberculosis M6 -1.7 12 Cebpg|Il12b|Lbp|Myd88|Rfxank|Sphk1|Tlr6|Tnf|Traf6|Tcirg1|Calm5|H2-Ea-ps KEGG Pathway mmu04650 Natural killer cell mediated cytotoxicity M6 -1.7 9 H2-D1|Ifnar2|Klra4|Klra7|Klra9|Pik3cd|Pik3r2|Tnf|Zap70 KEGG Pathway mmu01200 Carbon metabolism M6 -1.7 9 Fbp1|Got1|Pklr|Rpia|Pgls|Pccb|Acss1|Tktl2|Prps1l1 GO Biological Processes GO:0043537 negative regulation of blood vessel endothelial cell migration M6 -1.7 4 Angpt4|Csnk2b|Pik3r2|Rgcc GO Biological Processes GO:0032755 positive regulation of interleukin-6 production M6 -1.7 8 Arhgef2|Lbp|Myd88|Tlr6|Tnf|Traf6|Zfp64|Arid5a GO Biological Processes GO:1903557 positive regulation of tumor necrosis factor superfamily cytokine production M6 -1.7 8 Il12b|Arhgef2|Lbp|Myd88|Ccl2|Zfp64|Arfgef2|Arid5a GO Biological Processes GO:0046579 positive regulation of Ras protein signal transduction M6 -1.7 6 F2rl2|Map4k4|Lpar2|Rtn4|Nrg1|Gpr4 GO Biological Processes GO:0032946 positive regulation of mononuclear cell proliferation M6 -1.7 10 Bst1|Cd6|Il12b|Il12rb1|Jak3|Myd88|Ptpn22|Spta1|Traf6|Zap70 GO Biological Processes GO:1990266 neutrophil migration M6 -1.7 9 Bst1|Lbp|Myd88|Ccl2|Ccl7|Rtn4|Itga1|Camk1d|Prex1 GO Molecular Functions GO:0022804 active transmembrane transporter activity M6 -1.7 20 Abcb4|Slc1a2|Slc23a1|Slc34a2|Slc4a3|Slc5a1|Abcc9|Tcirg1|Slco1c1|Slc15a3|Abca14|Atp6v1d|Slc24a3|Slc45a4|Slco3a1|Slc5a5|Slco5a1|Slc26a11|Slc47a2|Abca17 GO Biological Processes GO:0002456 T cell mediated immunity M6 -1.7 10 Dpp4|H2-D1|H2-Q1|H2-T3|Il12b|Nectin2|Traf6|Arid5a|H2-M10.5|H60c GO Biological Processes GO:0042176 regulation of protein catabolic process M6 -1.6 21 Axin1|Cst3|Dvl1|Rps7|Tnf|Ube2g2|Pdcl3|Ankib1|Fam83d|Trim39|Cdk5rap3|Trem2|Nkd1|Laptm4b|Trim40|Chmp6|Lpcat1|Nrg1|Bag2|Dlgap1|Lrig2 GO Molecular Functions GO:0051184 cofactor transmembrane transporter activity M6 -1.6 3 Hpx|Slc23a1|Flvcr1 GO Molecular Functions GO:0030676 Rac guanyl-nucleotide exchange factor activity M6 -1.6 3 Arhgef2|Farp1|Prex1 GO Biological Processes GO:0043252 sodium-independent organic anion transport M6 -1.6 3 Slco1c1|Slco3a1|Slco5a1 GO Biological Processes GO:2000810 regulation of bicellular tight junction assembly M6 -1.6 3 Epha2|Tnf|Nphp4 GO Biological Processes GO:0045088 regulation of innate immune response M6 -1.6 17 Hpx|Ifi204|Il12b|Acod1|Lbp|Myd88|Ptpn22|Nectin2|Tfeb|Tlr6|Tnf|Rtn4|Trem2|Trim6|Nploc4|9830107B12Rik|H60c GO Biological Processes GO:0051091 positive regulation of DNA-binding transcription factor activity M6 -1.6 15 Arhgef2|Myd88|Sphk1|Trim21|Tlr6|Tnf|Traf6|Cops5|Rgcc|Nfam1|Adgrf1|Card14|Trim31|Pprc1|Camk1d GO Biological Processes GO:0031572 G2 DNA damage checkpoint M6 -1.6 4 Mbd4|Babam1|Cdk5rap3|Taok3 Reactome Gene Sets R-MMU-1483166 Synthesis of PA M6 -1.6 4 Pla2g2f|Agpat1|Ddhd1|Lpcat1 GO Biological Processes GO:0045672 positive regulation of osteoclast differentiation M6 -1.6 4 Il12b|Tnf|Traf6|Trem2 GO Biological Processes GO:0002486 antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TA M6 -1.6 4 H2-D1|H2-Q1|H2-T3|H2-M10.5 GO Biological Processes GO:1903827 regulation of cellular protein localization M6 -1.6 27 Cep131|Bard1|Dvl1|Epha2|Myo5b|Nf2|Pik3r2|Ptpn22|Rangap1|Ccl2|Srebf1|Tnf|Ube2g2|Stx6|Pdzk1|Rtn4|C2cd5|Mrap|Cdk5rap3|Trem2|Sec16b|Maged1|Trim40|Nrg1|Crocc|Lrig2|Epb41 GO Biological Processes GO:0042088 T-helper 1 type immune response M6 -1.6 5 Il12b|Il12rb1|Jak3|Traf6|Arid5a GO Biological Processes GO:0002718 regulation of cytokine production involved in immune response M6 -1.6 7 Hmox1|Jak3|Tnf|Traf6|Rtn4|Trim6|Arid5a GO Biological Processes GO:0019932 second-messenger-mediated signaling M6 -1.6 23 Adcy7|Bst1|Gal|Guca1a|Insl3|Nme2|Pde9a|Sphk1|Tnf|Zap70|Homer3|Cherp|Treml1|Selenon|Mrap|Adgrf1|Trem2|Sri|Nrg1|Tpcn2|Akap6|Gucy1b2|Calm5 GO Molecular Functions GO:0015077 monovalent inorganic cation transmembrane transporter activity M6 -1.6 20 Cox6c|Gria2|Kcnk5|Scn10a|Slc1a2|Slc23a1|Slc34a2|Slc5a1|Abcc9|Tcirg1|Kcnj1|Slc15a3|Scn2b|Atp6v1d|Kcnip2|Kcnn1|Slc24a3|Slc45a4|Slc5a5|Lrrc38 Reactome Gene Sets R-MMU-6794361 Neurexins and neuroligins M6 -1.6 4 Homer3|Nlgn1|Dlgap1|Epb41 GO Biological Processes GO:0002484 antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway M6 -1.6 4 H2-D1|H2-Q1|H2-T3|H2-M10.5 GO Biological Processes GO:0032660 regulation of interleukin-17 production M6 -1.6 4 Il12b|Myd88|Sphk1|Arid5a GO Biological Processes GO:0002476 antigen processing and presentation of endogenous peptide antigen via MHC class Ib M6 -1.6 4 H2-D1|H2-Q1|H2-T3|H2-M10.5 Reactome Gene Sets R-MMU-432720 Lysosome Vesicle Biogenesis M6 -1.6 4 Ap1m1|M6pr|Ap4b1|Dnajc6 GO Biological Processes GO:0032635 interleukin-6 production M6 -1.6 11 Arhgef2|Lbp|Myd88|Ptpn22|Tlr6|Tnf|Traf6|Zfp64|Trem2|Arid5a|Bank1 GO Biological Processes GO:0009064 glutamine family amino acid metabolic process M6 -1.6 6 Fpgs|Got1|Slc7a7|Ddah2|Dglucy|Lgsn GO Biological Processes GO:0009408 response to heat M6 -1.6 8 Hspa5|Hmox1|Hspa4|Ier5|Pklr|Ccl2|Slc52a3|Lrp11 GO Biological Processes GO:0002367 cytokine production involved in immune response M6 -1.6 8 Hmox1|Il12b|Jak3|Tnf|Traf6|Rtn4|Trim6|Arid5a GO Molecular Functions GO:0004252 serine-type endopeptidase activity M6 -1.6 12 C2|Dpp4|Cfb|Tpsg1|Prss30|Corin|Cela1|Prss27|Tmprss4|Tmprss13|Tmprss11f|Tmprss11c GO Biological Processes GO:0021535 cell migration in hindbrain M6 -1.6 3 Ulk1|Rere|Rbfox2 GO Biological Processes GO:0033173 calcineurin-NFAT signaling cascade M6 -1.6 5 Tnf|Homer3|Cherp|Nrg1|Akap6 Reactome Gene Sets R-MMU-193648 NRAGE signals death through JNK M6 -1.6 5 Arhgef2|Arhgef10l|Arhgef17|Arhgef19|Prex1 GO Biological Processes GO:0007254 JNK cascade M6 -1.6 13 Axin1|Myd88|Ptpn22|Tlr6|Tnf|Traf6|Map3k5|Cops5|Map4k4|Dusp3|Unc5cl|Tnxb|Taok3 GO Molecular Functions GO:0019887 protein kinase regulator activity M6 -1.6 11 Angpt4|Ccnd3|Csnk2b|Tcl1b5|Ccnl2|Rgcc|Gprc5d|Inka2|Spred2|Nrg1|Gprc5a GO Biological Processes GO:0034504 protein localization to nucleus M6 -1.6 16 Bard1|Dvl1|Nf2|Pik3r2|Ptpn22|Rangap1|Wrn|Taf8|Cdk5rap3|Maged1|Trim40|Sprn|Tmem201|Tor1aip2|Syne2|1700015F17Rik GO Biological Processes GO:0043087 regulation of GTPase activity M6 -1.6 17 Epha2|Ptprn2|Rangap1|Ccl2|Ccl7|Map4k4|Tbc1d20|Tbc1d9|Arhgap15|Trappc6b|Rab3gap2|Plxnb2|Dock10|Arhgef19|Prex1|Lrch1|Iqgap2 GO Cellular Components GO:0043198 dendritic shaft M6 -1.6 6 Gria2|Arhgef2|Slc1a2|Nlgn1|Lzts1|Prex1 GO Biological Processes GO:0050710 negative regulation of cytokine secretion M6 -1.6 6 Fn1|Ptpn22|Tlr6|Tnf|Rgcc|Bank1 GO Biological Processes GO:0032680 regulation of tumor necrosis factor production M6 -1.6 11 Il12b|Arhgef2|Lbp|Myd88|Ptpn22|Ccl2|Tlr6|Zfp64|Trem2|Arfgef2|Arid5a GO Biological Processes GO:0030865 cortical cytoskeleton organization M6 -1.5 5 Tnf|Cavin3|Nlgn1|Ehd2|Epb41 GO Biological Processes GO:0043405 regulation of MAP kinase activity M6 -1.5 17 Axin1|Ptpn22|Tlr6|Tnf|Traf6|Gdf15|Map3k5|Pik3cg|Lpar2|Dusp3|Cdk5rap3|Tnxb|Maged1|Itga1|Spred2|Taok3|Nek10 GO Biological Processes GO:0048194 Golgi vesicle budding M6 -1.5 4 Tbc1d20|Sec24a|Sec16b|Myo18a GO Biological Processes GO:0006739 NADP metabolic process M6 -1.5 4 Fdxr|Rpia|Pgls|Nadk GO Biological Processes GO:0002428 antigen processing and presentation of peptide antigen via MHC class Ib M6 -1.5 4 H2-D1|H2-Q1|H2-T3|H2-M10.5 GO Biological Processes GO:0050764 regulation of phagocytosis M6 -1.5 8 C2|Lbp|Ccl2|Sphk1|Tnf|Trem2|Camk1d|Myo18a GO Biological Processes GO:0070665 positive regulation of leukocyte proliferation M6 -1.5 10 Bst1|Cd6|Il12b|Il12rb1|Jak3|Myd88|Ptpn22|Spta1|Traf6|Zap70 GO Biological Processes GO:0032606 type I interferon production M6 -1.5 7 Acod1|Irf9|Myd88|Ptpn22|Zfp64|Traf3ip1|Nploc4 GO Biological Processes GO:0048002 antigen processing and presentation of peptide antigen M6 -1.5 6 H2-D1|H2-Q1|H2-T3|Traf6|Trem2|H2-M10.5 Reactome Gene Sets R-MMU-6794362 Protein-protein interactions at synapses M6 -1.5 6 Grin1|Ptprf|Homer3|Nlgn1|Dlgap1|Epb41 GO Biological Processes GO:1903829 positive regulation of cellular protein localization M6 -1.5 17 Cep131|Epha2|Myo5b|Pik3r2|Ptpn22|Ccl2|Tnf|Pdzk1|Rtn4|C2cd5|Cdk5rap3|Trem2|Sec16b|Nrg1|Crocc|Lrig2|Epb41 GO Cellular Components GO:0044292 dendrite terminus M6 -1.5 3 Cobl|Rgs11|Rtn4 GO Biological Processes GO:0034143 regulation of toll-like receptor 4 signaling pathway M6 -1.5 3 Acod1|Lbp|Ptpn22 GO Biological Processes GO:0002523 leukocyte migration involved in inflammatory response M6 -1.5 3 Lbp|Ccl2|Rtn4 GO Molecular Functions GO:0005402 carbohydrate:cation symporter activity M6 -1.5 3 Slc23a1|Slc5a1|Slc45a4 Reactome Gene Sets R-MMU-912526 Interleukin receptor SHC signaling M6 -1.5 3 Jak3|Pik3cd|Pik3r2 GO Biological Processes GO:1903555 regulation of tumor necrosis factor superfamily cytokine production M6 -1.5 11 Il12b|Arhgef2|Lbp|Myd88|Ptpn22|Ccl2|Tlr6|Zfp64|Trem2|Arfgef2|Arid5a KEGG Pathway mmu04141 Protein processing in endoplasmic reticulum M6 -1.5 11 Hspa5|Rpn2|Ube2g2|Map3k5|Sec24a|Bag2|Ckap4|Nploc4|Ubqln3|Ubqlnl|Uggt1 GO Biological Processes GO:0007032 endosome organization M6 -1.5 5 Stx6|Pi4k2b|Fam160a2|Arfgef2|Laptm4b Reactome Gene Sets R-MMU-72695 Formation of the ternary complex, and subsequently, the 43S complex M6 -1.5 5 Rps18|Rps7|Eif3g|Rps21|Eif2s2 GO Biological Processes GO:0045089 positive regulation of innate immune response M6 -1.5 14 Hpx|Ifi204|Il12b|Acod1|Lbp|Myd88|Ptpn22|Nectin2|Tlr6|Tnf|Rtn4|Trim6|Nploc4|H60c GO Biological Processes GO:0002831 regulation of response to biotic stimulus M6 -1.5 10 Il12b|Il12rb1|Acod1|Ptpn22|Nectin2|Tfeb|Traf6|Traf3ip1|Trim6|Nploc4 GO Biological Processes GO:0032640 tumor necrosis factor production M6 -1.5 11 Il12b|Arhgef2|Lbp|Myd88|Ptpn22|Ccl2|Tlr6|Zfp64|Trem2|Arfgef2|Arid5a GO Biological Processes GO:0060142 regulation of syncytium formation by plasma membrane fusion M6 -1.5 4 Nfe2|Gdf15|Trem2|Ehd2 GO Biological Processes GO:0009187 cyclic nucleotide metabolic process M6 -1.5 4 Adcy7|Epha2|Pde1a|Pde9a GO Molecular Functions GO:0048365 Rac GTPase binding M6 -1.5 6 Dvl1|Arhgef2|Arhgap17|Farp1|Prex1|Iqgap2 GO Molecular Functions GO:0015291 secondary active transmembrane transporter activity M6 -1.5 14 Slc1a2|Slc23a1|Slc34a2|Slc4a3|Slc5a1|Slco1c1|Slc15a3|Slc24a3|Slc45a4|Slco3a1|Slc5a5|Slco5a1|Slc26a11|Slc47a2 GO Biological Processes GO:0097720 calcineurin-mediated signaling M6 -1.5 5 Tnf|Homer3|Cherp|Nrg1|Akap6 GO Biological Processes GO:0043268 positive regulation of potassium ion transport M6 -1.5 5 Gal|Kcnip2|Trem2|Akap6|Lrrc38 KEGG Pathway mmu05014 Amyotrophic lateral sclerosis (ALS) M6 -1.5 5 Gria2|Grin1|Slc1a2|Tnf|Map3k5 KEGG Pathway mmu05150 Staphylococcus aureus infection M6 -1.5 5 C2|C4b|Cfb|Dsg1c|H2-Ea-ps GO Biological Processes GO:0072698 protein localization to microtubule cytoskeleton M6 -1.5 5 Cep131|Dvl1|Mid1|Cep63|Fam83d GO Biological Processes GO:0051057 positive regulation of small GTPase mediated signal transduction M6 -1.5 6 F2rl2|Map4k4|Lpar2|Rtn4|Nrg1|Gpr4 GO Biological Processes GO:0071902 positive regulation of protein serine/threonine kinase activity M6 -1.5 16 Axin1|Ccnd3|Tlr6|Tnf|Traf6|Gdf15|Map3k5|Pik3cg|Lpar2|Rgcc|Telo2|Maged1|Itga1|Akap6|Taok3|Nek10 GO Biological Processes GO:0015813 L-glutamate transmembrane transport M6 -1.5 3 Per2|Slc1a2|Tnf GO Biological Processes GO:0002577 regulation of antigen processing and presentation M6 -1.5 3 Ptpn22|Trem2|Ythdf1 GO Biological Processes GO:1900017 positive regulation of cytokine production involved in inflammatory response M6 -1.5 3 Cd6|Myd88|Tlr6 GO Molecular Functions GO:0044183 protein binding involved in protein folding M6 -1.5 3 Hspa5|Pdcl3|Calr3 GO Biological Processes GO:0007095 mitotic G2 DNA damage checkpoint M6 -1.5 3 Mbd4|Cdk5rap3|Taok3 Reactome Gene Sets R-MMU-912631 Regulation of signaling by CBL M6 -1.5 3 Pik3cd|Pik3r2|Uba52 GO Biological Processes GO:0008356 asymmetric cell division M6 -1.5 3 Arhgef2|Pou5f1|Stra8 KEGG Pathway mmu05143 African trypanosomiasis M6 -1.5 4 Il12b|Myd88|Plcb2|Tnf KEGG Pathway mmu04270 Vascular smooth muscle contraction M6 -1.5 9 Acta2|Adcy7|Cyp4a12b|Plcb2|Pla2g2e|Pla2g2f|Myl9|Gucy1b2|Calm5 GO Biological Processes GO:0001910 regulation of leukocyte mediated cytotoxicity M6 -1.5 8 H2-D1|H2-Q1|H2-T3|Il12b|Nectin2|Ccl2|H2-M10.5|H60c GO Biological Processes GO:0071706 tumor necrosis factor superfamily cytokine production M6 -1.5 11 Il12b|Arhgef2|Lbp|Myd88|Ptpn22|Ccl2|Tlr6|Zfp64|Trem2|Arfgef2|Arid5a GO Biological Processes GO:0061900 glial cell activation M6 -1.5 5 Cst7|Sphk1|Tlr6|Tnf|Trem2 GO Biological Processes GO:0003341 cilium movement M6 -1.4 6 Dync1h1|Tekt2|Dnah10|Cfap53|Kif27|Ccdc63 GO Biological Processes GO:0042509 regulation of tyrosine phosphorylation of STAT protein M6 -1.4 6 Crlf1|Hpx|Il12b|Nf2|Tnf|Traf3ip1 GO Biological Processes GO:0051056 regulation of small GTPase mediated signal transduction M6 -1.4 15 F2rl2|Fbp1|Arhgef2|Map4k4|Lpar2|Rtn4|Arhgef10l|Arfgef2|Arhgef17|Nrg1|Arhgef19|Farp1|Kank2|Prex1|Gpr4 Reactome Gene Sets R-MMU-5653656 Vesicle-mediated transport M6 -1.4 28 Ap1m1|Dync1h1|Fnbp1|Hpx|M6pr|Spta1|Tpd52|Uba52|Ulk1|Pacsin2|Cops5|Stx6|Necap2|Use1|Tbc1d20|Ap4b1|Dnajc6|Mvb12a|Kif2c|Kif27|Sec24a|Trappc6b|Sec16b|Rab3gap2|Vps37c|Chmp6|Rabepk|Apol7e GO Cellular Components GO:0043197 dendritic spine M6 -1.4 12 Apbb1|Dvl1|Gria2|Grin1|Myl7|Myo5b|Slc1a2|Arfgef2|Sri|Nlgn1|Dock10|Lzts1 KEGG Pathway mmu04380 Osteoclast differentiation M6 -1.4 9 Ifnar2|Irf9|Mitf|Pik3cd|Pik3r2|Pirb|Tnf|Traf6|Trem2 GO Molecular Functions GO:0019955 cytokine binding M6 -1.4 9 Crlf1|Ifnar2|Il12b|Il12rb1|Lifr|Pou5f1|Cops5|Hjv|Ltbp1 GO Biological Processes GO:0001776 leukocyte homeostasis M6 -1.4 8 Jak3|Pik3cd|Pirb|Ccl2|Spta1|Tcirg1|Tnfrsf13b|Dock10 Reactome Gene Sets R-MMU-202733 Cell surface interactions at the vascular wall M6 -1.4 8 Angpt4|Dok2|Fn1|Pik3r2|Procr|Slc7a5|Slc7a7|Psg22 GO Biological Processes GO:0031669 cellular response to nutrient levels M6 -1.4 12 Hspa5|Nprl3|Srebf1|Ulk1|Wrn|Map3k5|Slc39a4|Dapl1|Rrp8|Szt2|Tnrc6a|Kank2 GO Biological Processes GO:0009108 coenzyme biosynthetic process M6 -1.4 12 Fbp1|Fdxr|Fpgs|Eif6|Pklr|Coq8a|Acss1|Atic|Nadk|Dhtkd1|Nmrk1|Pdk1 GO Molecular Functions GO:0043394 proteoglycan binding M6 -1.4 4 Col5a1|Fn1|Ptprf|Psg22 GO Biological Processes GO:0045601 regulation of endothelial cell differentiation M6 -1.4 4 Notch4|Tnf|Xdh|Atoh8 GO Biological Processes GO:0001782 B cell homeostasis M6 -1.4 4 Pik3cd|Pirb|Tnfrsf13b|Dock10 GO Biological Processes GO:0031341 regulation of cell killing M6 -1.4 9 H2-D1|H2-Q1|H2-T3|Il12b|Nectin2|Ccl2|H2-M10.5|Pglyrp4|H60c GO Cellular Components GO:0030175 filopodium M6 -1.4 7 Apbb1|Dync1h1|Nf2|Cd302|Nlgn1|Syne2|Iqgap2 GO Biological Processes GO:0032964 collagen biosynthetic process M6 -1.4 5 Col5a1|Got1|Ccl2|Rgcc|Ltbp1 GO Biological Processes GO:0019882 antigen processing and presentation M6 -1.4 8 H2-D1|H2-Q1|H2-T3|Ptpn22|Traf6|Trem2|H2-M10.5|Ythdf1 GO Biological Processes GO:0043410 positive regulation of MAPK cascade M6 -1.4 26 Acta2|Axin1|Gcnt2|Mid1|Myd88|Ptpn22|Ccl2|Ccl7|Sphk1|Tlr6|Tnf|Traf6|Xdh|Gdf15|Map3k5|Map4k4|Pik3cg|Lpar2|Unc5cl|Trem2|Maged1|Cavin3|Itga1|Bank1|Taok3|Nek10 GO Biological Processes GO:2000010 positive regulation of protein localization to cell surface M6 -1.4 3 Tnf|Nrg1|Lrig2 GO Molecular Functions GO:0090482 vitamin transmembrane transporter activity M6 -1.4 3 Slc23a1|Slc52a2|Slc52a3 GO Molecular Functions GO:0008483 transaminase activity M6 -1.4 3 Bcat1|Got1|Got1l1 GO Molecular Functions GO:0031420 alkali metal ion binding M6 -1.4 3 Pklr|Slc34a2|Kcnj1 GO Biological Processes GO:0046641 positive regulation of alpha-beta T cell proliferation M6 -1.4 3 Il12b|Ptpn22|Zap70 GO Biological Processes GO:0002706 regulation of lymphocyte mediated immunity M6 -1.4 12 Dpp4|H2-D1|H2-Q1|H2-T3|Hpx|Il12b|Nectin2|Tnf|Traf6|Arid5a|H2-M10.5|H60c KEGG Pathway mmu04918 Thyroid hormone synthesis M6 -1.4 6 Adcy7|Gsr|Hspa5|Plcb2|Tg|Slc5a5 GO Molecular Functions GO:0030971 receptor tyrosine kinase binding M6 -1.4 6 Angpt4|Dok2|Pik3r2|Ptprf|Dusp3|Nrg1 GO Biological Processes GO:0006732 coenzyme metabolic process M6 -1.4 18 Fbp1|Fdxr|Fpgs|Eif6|Ldhb|Pemt|Pklr|Rpia|Pgls|Coq8a|Acss1|Glyat|Atic|Nadk|Dhtkd1|Nmrk1|Pdk1|Far2 Reactome Gene Sets R-MMU-6798695 Neutrophil degranulation M6 -1.4 26 Aga|Prdx6|Ap1m1|Bst1|Csnk2b|Cst3|Dync1h1|H2-Q1|Ifi204|Nme2|Pirb|Ptprn2|Tcirg1|Rnase2b|Hebp2|Psmd11|Vps35l|Atp6v1d|Nfam1|Acaa1a|Lpcat1|Ckap4|H2-M10.5|Enpp4|Psg22|Iqgap2 GO Biological Processes GO:0061512 protein localization to cilium M6 -1.4 5 Atp6v1d|Arl13a|Ift140|Crocc|Nphp4 GO Cellular Components GO:0001533 cornified envelope M6 -1.4 5 Sprr2d|Sprr2e|Sprr3|Lelp1|Kazn Reactome Gene Sets R-MMU-202403 TCR signaling M6 -1.4 5 Pik3r2|Ptpn22|Traf6|Uba52|Zap70 GO Biological Processes GO:1902475 L-alpha-amino acid transmembrane transport M6 -1.4 4 Per2|Slc1a2|Slc7a5|Tnf KEGG Pathway mmu04960 Aldosterone-regulated sodium reabsorption M6 -1.4 4 Pik3cd|Pik3r2|Kcnj1|Nr3c2 GO Biological Processes GO:0002475 antigen processing and presentation via MHC class Ib M6 -1.4 4 H2-D1|H2-Q1|H2-T3|H2-M10.5 GO Biological Processes GO:0046854 phosphatidylinositol phosphorylation M6 -1.4 4 Pik3cd|Pik3r2|Pik3cg|Pi4k2b GO Biological Processes GO:0006778 porphyrin-containing compound metabolic process M6 -1.4 4 Hebp1|Hmox1|Hpx|Spta1 GO Biological Processes GO:0070570 regulation of neuron projection regeneration M6 -1.4 4 Ptprf|Map4k4|Rtn4|Lrig2 GO Biological Processes GO:0072595 maintenance of protein localization in organelle M6 -1.4 4 Bard1|Hspa5|Rangap1|Taf8 GO Biological Processes GO:0032101 regulation of response to external stimulus M6 -1.4 36 Adcy7|Bst1|Cd6|Cst7|Dvl1|Fn1|Grin1|Il12b|Il12rb1|Acod1|Lbp|Myd88|Ptgis|Ptpn22|Ptprf|Ccl2|Sphk1|Tfeb|Tfpi|Tlr6|Tnf|Traf6|Pik3cg|Pglyrp2|Rtn4|Dusp3|Traf3ip1|Trem2|Trim6|Nploc4|Enpp4|Camk1d|Ythdf1|Kank2|Zswim8|Lrig2 GO Biological Processes GO:0071900 regulation of protein serine/threonine kinase activity M6 -1.4 22 Axin1|Ccnd3|Ptpn22|Tesk1|Tlr6|Tnf|Traf6|Gdf15|Map3k5|Pik3cg|Lpar2|Rgcc|Telo2|Dusp3|Cdk5rap3|Tnxb|Maged1|Itga1|Spred2|Akap6|Taok3|Nek10 GO Biological Processes GO:0042116 macrophage activation M6 -1.4 7 Cst7|Lbp|Sphk1|Tlr6|Tnf|Trem2|Myo18a GO Biological Processes GO:0002705 positive regulation of leukocyte mediated immunity M6 -1.4 11 H2-D1|H2-Q1|H2-T3|Hpx|Il12b|Nectin2|Tnf|Traf6|Arid5a|H2-M10.5|H60c GO Cellular Components GO:0044309 neuron spine M6 -1.4 12 Apbb1|Dvl1|Gria2|Grin1|Myl7|Myo5b|Slc1a2|Arfgef2|Sri|Nlgn1|Dock10|Lzts1 GO Biological Processes GO:0042108 positive regulation of cytokine biosynthetic process M6 -1.4 6 Cebpg|Lbp|Myd88|Tlr6|Tnf|Traf6 GO Molecular Functions GO:0008047 enzyme activator activity M6 -1.4 23 Angpt4|Fn1|Guca1a|Guca2a|Nprl3|Rangap1|Rgs9|Tcl1b5|Rgs11|Rgcc|Tbc1d20|Arhgap17|Tbc1d9|Arhgef10l|Arhgap8|Arhgap15|Gmip|Gprc5d|Rab3gap2|Nrg1|Arhgef19|Gprc5a|Tor1aip2 GO Cellular Components GO:0005903 brush border M6 -1.4 9 Myo5b|Myo7b|Pemt|Prom1|Slc23a1|Slc34a2|Slc5a1|Pdzk1|Myo18a KEGG Pathway mmu00360 Phenylalanine metabolism M6 -1.4 3 Got1|Keg1|Glyat GO Biological Processes GO:1902884 positive regulation of response to oxidative stress M6 -1.4 3 Tlr6|Tnf|Selenon GO Biological Processes GO:0051457 maintenance of protein location in nucleus M6 -1.4 3 Bard1|Rangap1|Taf8 GO Biological Processes GO:0002719 negative regulation of cytokine production involved in immune response M6 -1.4 3 Hmox1|Jak3|Tnf GO Molecular Functions GO:0005540 hyaluronic acid binding M6 -1.4 3 Ncan|Hapln3|Hapln4 GO Biological Processes GO:0002827 positive regulation of T-helper 1 type immune response M6 -1.4 3 Il12b|Il12rb1|Arid5a GO Biological Processes GO:0006733 oxidoreduction coenzyme metabolic process M6 -1.4 11 Fbp1|Fdxr|Eif6|Ldhb|Pklr|Rpia|Pgls|Coq8a|Nadk|Dhtkd1|Nmrk1 Reactome Gene Sets R-MMU-917937 Iron uptake and transport M6 -1.4 5 Hmox1|Uba52|Tcirg1|Atp6v1d|Flvcr1 GO Biological Processes GO:0035456 response to interferon-beta M6 -1.4 5 Ifi204|Ifnar2|Acod1|Ube2g2|Trim6 GO Biological Processes GO:0034765 regulation of ion transmembrane transport M6 -1.4 24 Clcnka|Gal|Per2|Ptpn22|Rgs9|Scn10a|Ccl2|Tnf|Tcirg1|Pik3cg|Clcnkb|Kcnj1|Pdzk1|1810037I17Rik|Scn2b|Selenon|Kcnip2|Trem2|Sri|Nlgn1|Tpcn2|Akap6|Lrrc38|Catsper4 Reactome Gene Sets R-MMU-425407 SLC-mediated transmembrane transport M6 -1.4 13 Slc34a2|Slc4a3|Slc5a1|Slc7a5|Slc7a7|Slco1c1|Slc29a1|Slc15a3|Slc39a4|Slc35b2|Slco3a1|Sri|Slc26a11 GO Molecular Functions GO:0003712 transcription coregulator activity M6 -1.4 23 Aebp2|Ifi204|Mak|Nme2|Per2|Pou5f1|Scand1|Sin3b|Tcp10b|Cops5|Brd7|Spen|Insm2|Med31|Rere|Med30|Kdm5b|Rbfox2|Maged1|Nrg1|Arid5a|Pprc1|Thrap3 Reactome Gene Sets R-MMU-425393 Transport of inorganic cations/anions and amino acids/oligopeptides M6 -1.4 7 Slc34a2|Slc4a3|Slc7a5|Slc7a7|Slc15a3|Sri|Slc26a11 GO Biological Processes GO:0002483 antigen processing and presentation of endogenous peptide antigen M6 -1.4 4 H2-D1|H2-Q1|H2-T3|H2-M10.5 GO Biological Processes GO:0019885 antigen processing and presentation of endogenous peptide antigen via MHC class I M6 -1.4 4 H2-D1|H2-Q1|H2-T3|H2-M10.5 GO Biological Processes GO:0060337 type I interferon signaling pathway M6 -1.4 4 Ifnar2|Myd88|Trim6|Oas2 GO Biological Processes GO:0071357 cellular response to type I interferon M6 -1.4 4 Ifnar2|Myd88|Trim6|Oas2 GO Biological Processes GO:0044088 regulation of vacuole organization M6 -1.4 4 Nprl3|Ulk1|Rab3gap2|Laptm4b GO Biological Processes GO:1901224 positive regulation of NIK/NF-kappaB signaling M6 -1.3 6 Ptp4a3|Sphk1|Tnf|Traf6|Trem2|Nr3c2 GO Biological Processes GO:0031668 cellular response to extracellular stimulus M6 -1.3 13 Hspa5|Nprl3|Slc1a2|Srebf1|Ulk1|Wrn|Map3k5|Slc39a4|Dapl1|Rrp8|Szt2|Tnrc6a|Kank2 GO Biological Processes GO:0048016 inositol phosphate-mediated signaling M6 -1.3 5 Tnf|Homer3|Cherp|Nrg1|Akap6 GO Cellular Components GO:0001917 photoreceptor inner segment M6 -1.3 5 Guca1a|Mak|Rgs9|Cerkl|Crocc Reactome Gene Sets R-MMU-6809371 Formation of the cornified envelope M6 -1.3 8 Krt19|Sprr2d|Sprr2e|Sprr3|Lelp1|Kazn|Lipk|Cdsn GO Biological Processes GO:2000181 negative regulation of blood vessel morphogenesis M6 -1.3 8 Angpt4|Epha2|Pik3r2|Ccl2|Xdh|Rgcc|Rtn4|Gpr4 GO Biological Processes GO:0010506 regulation of autophagy M6 -1.3 14 Hmox1|Nprl3|Pik3r2|Ptpn22|Srebf1|Trim21|Tfeb|Ulk1|Dapl1|Trem2|Rab3gap2|Lzts1|Tpcn2|Tmem150b GO Biological Processes GO:0072523 purine-containing compound catabolic process M6 -1.3 4 Pde1a|Pde9a|Xdh|Enpp4 GO Biological Processes GO:0032620 interleukin-17 production M6 -1.3 4 Il12b|Myd88|Sphk1|Arid5a GO Biological Processes GO:0006636 unsaturated fatty acid biosynthetic process M6 -1.3 4 Ptgis|Sphk1|Decr2|Scd3 KEGG Pathway mmu04975 Fat digestion and absorption M6 -1.3 4 Fabp1|Pla2g2e|Pla2g2f|Agpat1 Reactome Gene Sets R-MMU-512988 Interleukin-3, Interleukin-5 and GM-CSF signaling M6 -1.3 4 Jak3|Pik3cd|Pik3r2|Uba52 GO Biological Processes GO:0019068 virion assembly M6 -1.3 3 Tbc1d20|Mvb12a|Chmp6 GO Biological Processes GO:0098869 cellular oxidant detoxification M6 -1.3 3 Prdx6|Tnf|Szt2 GO Molecular Functions GO:0016769 transferase activity, transferring nitrogenous groups M6 -1.3 3 Bcat1|Got1|Got1l1 GO Cellular Components GO:0030057 desmosome M6 -1.3 3 Kazn|Dsg1c|Cdsn GO Cellular Components GO:0036452 ESCRT complex M6 -1.3 3 Mvb12a|Vps37c|Chmp6 GO Biological Processes GO:0050670 regulation of lymphocyte proliferation M6 -1.3 13 Bst1|Cd6|Gal|Il12b|Il12rb1|Jak3|Myd88|Ptpn22|Spta1|Traf6|Zap70|Pla2g2f|Tnfrsf13b GO Cellular Components GO:0045121 membrane raft M6 -1.3 19 Cd79a|Cntn1|H2-D1|Hmox1|Ldhb|Nf2|Ptgis|Tfpi|Tlr6|Tnf|Zap70|Pacsin2|Pdzk1|Nfam1|Plvap|Cavin3|Itga1|Akap6|Ehd2 GO Biological Processes GO:0046394 carboxylic acid biosynthetic process M6 -1.3 19 Bcat1|Ccnd3|Fbp1|Fpgs|Got1|Eif6|Ldhb|Per2|Pklr|Ptgis|Sphk1|Srebf1|Decr2|Scd3|Acss1|Got1l1|Atic|Dhtkd1|Lgsn GO Cellular Components GO:0016607 nuclear speck M6 -1.3 17 Bard1|Brd2|Ifi204|Mbd4|Ogg1|Rbbp6|Wrn|Pacsin2|Tfip11|Zc3h13|Ddx39|Rreb1|Kazn|Unc45a|U2af1|Ckap4|Thrap3 Reactome Gene Sets R-MMU-72702 Ribosomal scanning and start codon recognition M6 -1.3 5 Rps18|Rps7|Eif3g|Rps21|Eif2s2 Reactome Gene Sets R-MMU-72649 Translation initiation complex formation M6 -1.3 5 Rps18|Rps7|Eif3g|Rps21|Eif2s2 GO Biological Processes GO:0044380 protein localization to cytoskeleton M6 -1.3 5 Cep131|Dvl1|Mid1|Cep63|Fam83d GO Cellular Components GO:0098802 plasma membrane receptor complex M6 -1.3 11 Cd6|Cd79a|Gria2|Grin1|Il12rb1|Tlr6|Traf6|Zap70|Hjv|Itga1|Nlgn1 GO Biological Processes GO:0050688 regulation of defense response to virus M6 -1.3 6 Il12b|Il12rb1|Ptpn22|Traf3ip1|Trim6|Nploc4 GO Biological Processes GO:0032088 negative regulation of NF-kappaB transcription factor activity M6 -1.3 6 Acod1|Ptgis|Trim21|Cdk5rap3|Trim40|Nwd1 GO Biological Processes GO:0032729 positive regulation of interferon-gamma production M6 -1.3 6 Cebpg|Il12b|Il12rb1|Ptpn22|Tnf|Arid5a GO Biological Processes GO:2001259 positive regulation of cation channel activity M6 -1.3 6 Gal|Rgs9|Ccl2|Trem2|Akap6|Lrrc38 GO Biological Processes GO:0009582 detection of abiotic stimulus 1Yr -3.7 8 Gnb1|Hpn|Htr7|Pkdrej|Arrb1|Asic3|Trpv1|Cngb1 GO Biological Processes GO:0009581 detection of external stimulus 1Yr -3.7 8 Gnb1|Hpn|Htr7|Pkdrej|Arrb1|Asic3|Trpv1|Cngb1 Reactome Gene Sets R-MMU-446107 Type I hemidesmosome assembly 1Yr -3.7 3 Col17a1|Dst|Lama3 GO Cellular Components GO:0030056 hemidesmosome 1Yr -3.7 3 Col17a1|Dst|Lama3 GO Molecular Functions GO:0099094 ligand-gated cation channel activity 1Yr -3.6 7 Chrng|Kcnj9|P2rx5|Asic3|Trpv1|Kcnj14|Cngb1 KEGG Pathway mmu04514 Cell adhesion molecules (CAMs) 1Yr -3.6 9 Cd6|Cntn1|H2-Q4|Madcam1|Nectin2|Cldn13|Cldn15|H2-M10.5|Nfasc Reactome Gene Sets R-MMU-1500931 Cell-Cell communication 1Yr -3.2 6 Col17a1|Dst|Lama3|Nectin2|Parva|Kirrel GO Biological Processes GO:0051606 detection of stimulus 1Yr -3.2 10 Gnb1|Hpn|Htr7|Pkdrej|Tlr6|Tas1r2|Arrb1|Asic3|Trpv1|Cngb1 Reactome Gene Sets R-MMU-446728 Cell junction organization 1Yr -2.9 5 Col17a1|Dst|Lama3|Nectin2|Parva KEGG Pathway mmu00770 Pantothenate and CoA biosynthesis 1Yr -2.9 3 Bcat1|Enpp1|Ppcs GO Biological Processes GO:0046324 regulation of glucose import 1Yr -2.9 5 Akt2|Enpp1|Slc1a2|C2cd5|Upk3b GO Molecular Functions GO:0015276 ligand-gated ion channel activity 1Yr -2.9 7 Chrng|Kcnj9|P2rx5|Asic3|Trpv1|Kcnj14|Cngb1 GO Cellular Components GO:0030864 cortical actin cytoskeleton 1Yr -2.8 6 Actn2|Utrn|Myadm|Wipf2|Anln|Pdlim2 GO Molecular Functions GO:0022834 ligand-gated channel activity 1Yr -2.8 7 Chrng|Kcnj9|P2rx5|Asic3|Trpv1|Kcnj14|Cngb1 GO Cellular Components GO:0005938 cell cortex 1Yr -2.7 11 Actn2|Akt2|Fabp1|Utrn|Nlrp5|Myadm|Crip2|Wipf2|Anln|C2cd5|Pdlim2 GO Biological Processes GO:0046323 glucose import 1Yr -2.6 5 Akt2|Enpp1|Slc1a2|C2cd5|Upk3b GO Molecular Functions GO:0008483 transaminase activity 1Yr -2.6 3 Bcat1|Got1l1|Kyat3 GO Cellular Components GO:0005911 cell-cell junction 1Yr -2.6 14 Dst|Hpn|Lama3|Abcb4|Nectin2|Myadm|Cldn13|Cldn15|Synpo|Kirrel|Pdlim2|Akap6|Nfasc|Cdsn GO Molecular Functions GO:0016769 transferase activity, transferring nitrogenous groups 1Yr -2.5 3 Bcat1|Got1l1|Kyat3 GO Cellular Components GO:0015629 actin cytoskeleton 1Yr -2.5 14 Actn2|Dst|Abcb4|Tnni3|Utrn|Mprip|Myadm|Parva|Wipf2|Anln|Tax1bp3|Stk17b|Synpo|Pdlim2 GO Biological Processes GO:0030865 cortical cytoskeleton organization 1Yr -2.5 4 Wipf2|Anln|Synpo|Ehd2 GO Biological Processes GO:0090630 activation of GTPase activity 1Yr -2.5 5 Akt2|Tbc1d1|Tbc1d2b|Tbc1d9|Tax1bp3 GO Biological Processes GO:0034113 heterotypic cell-cell adhesion 1Yr -2.4 4 Gcnt2|Madcam1|Myadm|Parva GO Biological Processes GO:0010827 regulation of glucose transmembrane transport 1Yr -2.4 5 Akt2|Enpp1|Slc1a2|C2cd5|Upk3b GO Cellular Components GO:0044448 cell cortex part 1Yr -2.4 8 Actn2|Fabp1|Utrn|Nlrp5|Myadm|Wipf2|Anln|Pdlim2 GO Cellular Components GO:0030055 cell-substrate junction 1Yr -2.3 7 Actn2|Col17a1|Dst|Lama3|Abcb4|Map4k4|Parva GO Biological Processes GO:0007602 phototransduction 1Yr -2.3 3 Gnb1|Arrb1|Cngb1 GO Molecular Functions GO:0005261 cation channel activity 1Yr -2.3 10 Chrng|Hpn|Kcnj9|Pkdrej|Scn3a|P2rx5|Asic3|Trpv1|Kcnj14|Cngb1 KEGG Pathway mmu05032 Morphine addiction 1Yr -2.2 5 Adcy7|Gnb1|Kcnj9|Pde1a|Arrb1 GO Cellular Components GO:0030863 cortical cytoskeleton 1Yr -2.2 6 Actn2|Utrn|Myadm|Wipf2|Anln|Pdlim2 Reactome Gene Sets R-MMU-1296065 Inwardly rectifying K+ channels 1Yr -2.2 3 Gnb1|Kcnj9|Kcnj14 GO Cellular Components GO:0099568 cytoplasmic region 1Yr -2.2 13 Actn2|Akt2|Camk2a|Fabp1|Utrn|Nlrp5|Myadm|Crip2|Wipf2|Anln|C2cd5|Pdlim2|Ccdc63 GO Biological Processes GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway 1Yr -2.2 5 Actn2|F2rl2|Fpr2|Gnb1|P2ry12 Reactome Gene Sets R-MMU-456926 Thrombin signalling through proteinase activated receptors (PARs) 1Yr -2.1 3 F2rl2|Gnb1|Arrb1 GO Molecular Functions GO:0003779 actin binding 1Yr -2.1 12 Actn2|Capg|Dst|Tnni3|Utrn|Mprip|Parva|Wipf2|Anln|Ush1c|Synpo|Pdlim2 GO Biological Processes GO:0050982 detection of mechanical stimulus 1Yr -2.1 4 Hpn|Htr7|Pkdrej|Asic3 GO Biological Processes GO:0010657 muscle cell apoptotic process 1Yr -2 5 Camk2a|Gnb1|Hmox1|Pde1a|Arrb1 GO Biological Processes GO:0033363 secretory granule organization 1Yr -2 3 Nectin2|Vps33b|Baiap3 GO Molecular Functions GO:0005231 excitatory extracellular ligand-gated ion channel activity 1Yr -2 3 Chrng|P2rx5|Trpv1 Reactome Gene Sets R-MMU-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell 1Yr -2 5 Col17a1|H2-Q4|Madcam1|Nectin2|H2-M10.5 GO Biological Processes GO:0009416 response to light stimulus 1Yr -2 9 Akt2|Ercc1|Gnb1|Slc1a2|Ctns|Synpo|Arrb1|Ccar2|Cngb1 Reactome Gene Sets R-MMU-977444 GABA B receptor activation 1Yr -2 3 Adcy7|Gnb1|Kcnj9 Reactome Gene Sets R-MMU-991365 Activation of GABAB receptors 1Yr -2 3 Adcy7|Gnb1|Kcnj9 GO Biological Processes GO:1904659 glucose transmembrane transport 1Yr -2 5 Akt2|Enpp1|Slc1a2|C2cd5|Upk3b GO Biological Processes GO:0043087 regulation of GTPase activity 1Yr -1.9 9 Akt2|Map4k4|Tbc1d1|Tbc1d2b|Chn2|Tbc1d9|Tax1bp3|Arrb1|Rasgrp3 GO Biological Processes GO:0008645 hexose transmembrane transport 1Yr -1.9 5 Akt2|Enpp1|Slc1a2|C2cd5|Upk3b GO Biological Processes GO:2000379 positive regulation of reactive oxygen species metabolic process 1Yr -1.9 5 Akt2|Fpr2|Tlr6|Xdh|Trpv1 GO Biological Processes GO:0002711 positive regulation of T cell mediated immunity 1Yr -1.9 4 H2-Q4|Nectin2|Arid5a|H2-M10.5 GO Molecular Functions GO:0098631 cell adhesion mediator activity 1Yr -1.9 3 Madcam1|Bcam|Nfasc GO Biological Processes GO:0015749 monosaccharide transmembrane transport 1Yr -1.9 5 Akt2|Enpp1|Slc1a2|C2cd5|Upk3b GO Biological Processes GO:0034219 carbohydrate transmembrane transport 1Yr -1.9 5 Akt2|Enpp1|Slc1a2|C2cd5|Upk3b GO Biological Processes GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage 1Yr -1.9 5 Bcl2a1c|Casp14|Hmox1|Bcl2l12|Ccar2 KEGG Pathway mmu04725 Cholinergic synapse 1Yr -1.9 5 Adcy7|Akt2|Camk2a|Gnb1|Kcnj14 Reactome Gene Sets R-MMU-418346 Platelet homeostasis 1Yr -1.9 4 Gnb1|Mrvi1|Pde1a|P2rx5 GO Cellular Components GO:0016529 sarcoplasmic reticulum 1Yr -1.9 4 Akt2|Mrvi1|Xdh|Akap6 GO Biological Processes GO:0046326 positive regulation of glucose import 1Yr -1.9 3 Akt2|Slc1a2|C2cd5 GO Biological Processes GO:1900015 regulation of cytokine production involved in inflammatory response 1Yr -1.8 3 Adcy7|Cd6|Tlr6 GO Biological Processes GO:0030866 cortical actin cytoskeleton organization 1Yr -1.8 3 Wipf2|Anln|Ehd2 GO Cellular Components GO:0031012 extracellular matrix 1Yr -1.8 12 Col17a1|Lama3|Lgals4|Lrrn2|Rbp3|Sftpb|Hapln3|2300002M23Rik|Mepe|Prelp|Optc|Tgm4 GO Cellular Components GO:0070161 anchoring junction 1Yr -1.8 9 Actn2|Dst|Lama3|Abcb4|Nectin2|Map4k4|Parva|Pdlim2|Cdsn GO Biological Processes GO:0051261 protein depolymerization 1Yr -1.8 5 Actn2|Capg|Mid1|Dnajc6|Eml4 GO Cellular Components GO:0045111 intermediate filament cytoskeleton 1Yr -1.8 6 Bfsp1|Casp14|Dst|Krt31|Ctns|Iffo2 GO Biological Processes GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process 1Yr -1.8 4 Akt2|Fabp1|Bcl2l12|Arrb1 Reactome Gene Sets R-MMU-5576891 Cardiac conduction 1Yr -1.7 5 Camk2a|Fxyd3|Scn3a|Tnni3|Kcnj14 GO Biological Processes GO:0001774 microglial cell activation 1Yr -1.7 3 Fpr2|Tlr6|Trpv1 GO Biological Processes GO:0002534 cytokine production involved in inflammatory response 1Yr -1.7 3 Adcy7|Cd6|Tlr6 GO Biological Processes GO:0002269 leukocyte activation involved in inflammatory response 1Yr -1.7 3 Fpr2|Tlr6|Trpv1 GO Biological Processes GO:0002274 myeloid leukocyte activation 1Yr -1.7 7 Fpr2|Hmox1|Pirb|Nectin2|Tlr6|Tac4|Trpv1 GO Biological Processes GO:0043547 positive regulation of GTPase activity 1Yr -1.7 7 Akt2|Map4k4|Tbc1d1|Tbc1d2b|Chn2|Tbc1d9|Tax1bp3 GO Cellular Components GO:0044853 plasma membrane raft 1Yr -1.7 5 Ms4a1|Hmox1|P2ry12|Akap6|Ehd2 GO Molecular Functions GO:0022839 ion gated channel activity 1Yr -1.7 9 Chrng|Hpn|Kcnj9|Scn3a|P2rx5|Asic3|Trpv1|Kcnj14|Cngb1 GO Biological Processes GO:0045429 positive regulation of nitric oxide biosynthetic process 1Yr -1.7 3 Akt2|Tlr6|Trpv1 GO Molecular Functions GO:0038024 cargo receptor activity 1Yr -1.7 4 Cd6|Fpr2|Enpp1|Arrb1 GO Cellular Components GO:0016528 sarcoplasm 1Yr -1.7 4 Akt2|Mrvi1|Xdh|Akap6 GO Cellular Components GO:0005882 intermediate filament 1Yr -1.7 5 Bfsp1|Casp14|Dst|Krt31|Iffo2 GO Biological Processes GO:0050974 detection of mechanical stimulus involved in sensory perception 1Yr -1.7 3 Hpn|Htr7|Asic3 GO Biological Processes GO:1904407 positive regulation of nitric oxide metabolic process 1Yr -1.7 3 Akt2|Tlr6|Trpv1 GO Cellular Components GO:0097517 contractile actin filament bundle 1Yr -1.7 4 Dst|Mprip|Synpo|Pdlim2 GO Biological Processes GO:0007044 cell-substrate junction assembly 1Yr -1.7 4 Actn2|Dst|Lama3|Map4k4 GO Biological Processes GO:0001912 positive regulation of leukocyte mediated cytotoxicity 1Yr -1.7 4 H2-Q4|Klrb1c|Nectin2|H2-M10.5 GO Biological Processes GO:0009593 detection of chemical stimulus 1Yr -1.7 4 Tlr6|Tas1r2|Asic3|Trpv1 GO Cellular Components GO:0001725 stress fiber 1Yr -1.7 4 Dst|Mprip|Synpo|Pdlim2 Reactome Gene Sets R-MMU-397014 Muscle contraction 1Yr -1.7 6 Actn2|Camk2a|Fxyd3|Scn3a|Tnni3|Kcnj14 GO Biological Processes GO:0001916 positive regulation of T cell mediated cytotoxicity 1Yr -1.6 3 H2-Q4|Nectin2|H2-M10.5 GO Molecular Functions GO:0008081 phosphoric diester hydrolase activity 1Yr -1.6 4 Gnb1|Hmox1|Pde1a|Enpp1 GO Biological Processes GO:2000117 negative regulation of cysteine-type endopeptidase activity 1Yr -1.6 4 Akt2|Fabp1|Bcl2l12|Arrb1 KEGG Pathway mmu00230 Purine metabolism 1Yr -1.6 6 Adcy7|Ampd3|Pde1a|Enpp1|Xdh|Polr3c GO Biological Processes GO:0031110 regulation of microtubule polymerization or depolymerization 1Yr -1.6 4 Dst|Mid1|Eml4|Gba2 GO Biological Processes GO:0010828 positive regulation of glucose transmembrane transport 1Yr -1.6 3 Akt2|Slc1a2|C2cd5 GO Molecular Functions GO:0022836 gated channel activity 1Yr -1.6 9 Chrng|Hpn|Kcnj9|Scn3a|P2rx5|Asic3|Trpv1|Kcnj14|Cngb1 GO Biological Processes GO:1901879 regulation of protein depolymerization 1Yr -1.6 4 Actn2|Capg|Mid1|Eml4 Reactome Gene Sets R-MMU-109582 Hemostasis 1Yr -1.6 12 Actn2|F2rl2|Gnb1|H3f3a|Mrvi1|Pde1a|Ceacam9|P2ry12|P2rx5|Arrb1|Klc3|Ehd2 GO Biological Processes GO:0009583 detection of light stimulus 1Yr -1.6 3 Gnb1|Arrb1|Cngb1 Reactome Gene Sets R-MMU-5578775 Ion homeostasis 1Yr -1.6 3 Camk2a|Fxyd3|Tnni3 KEGG Pathway mmu04144 Endocytosis 1Yr -1.6 8 H2-Q4|Wipf2|Dnajc6|Vps37c|Arrb1|Psd4|H2-M10.5|Ehd2 GO Biological Processes GO:0050906 detection of stimulus involved in sensory perception 1Yr -1.6 5 Hpn|Htr7|Tas1r2|Asic3|Trpv1 KEGG Pathway mmu04612 Antigen processing and presentation 1Yr -1.6 4 H2-Q4|Rfxank|Rfxap|H2-M10.5 GO Biological Processes GO:0015672 monovalent inorganic cation transport 1Yr -1.6 11 Actn2|Akt2|Cntn1|Hpn|Kcnj9|Fxyd3|Scn3a|P2ry12|Asic3|Kcnj14|Akap6 GO Biological Processes GO:0006813 potassium ion transport 1Yr -1.6 7 Actn2|Hpn|Kcnj9|Fxyd3|P2ry12|Kcnj14|Akap6 GO Biological Processes GO:0009791 post-embryonic development 1Yr -1.6 5 Ercc1|Tbce|Atf5|Etnk2|Impad1 GO Cellular Components GO:0099738 cell cortex region 1Yr -1.6 3 Fabp1|Nlrp5|Anln Reactome Gene Sets R-MMU-977443 GABA receptor activation 1Yr -1.6 3 Adcy7|Gnb1|Kcnj9 GO Biological Processes GO:0061900 glial cell activation 1Yr -1.6 3 Fpr2|Tlr6|Trpv1 Reactome Gene Sets R-MMU-112314 Neurotransmitter receptors and postsynaptic signal transmission 1Yr -1.6 5 Actn2|Adcy7|Camk2a|Gnb1|Kcnj9 GO Biological Processes GO:0051346 negative regulation of hydrolase activity 1Yr -1.5 10 Akt2|Fabp1|Hpn|Mcm2|Slpi|Tnni3|Mprip|Serpina1f|Bcl2l12|Arrb1 GO Biological Processes GO:0001914 regulation of T cell mediated cytotoxicity 1Yr -1.5 3 H2-Q4|Nectin2|H2-M10.5 GO Biological Processes GO:0043624 cellular protein complex disassembly 1Yr -1.5 5 Actn2|Capg|Mid1|Dnajc6|Eml4 GO Biological Processes GO:0016573 histone acetylation 1Yr -1.5 5 Tcf3|Trrap|Arrb1|Arid5a|Brd1 GO Biological Processes GO:0002709 regulation of T cell mediated immunity 1Yr -1.5 4 H2-Q4|Nectin2|Arid5a|H2-M10.5 GO Cellular Components GO:0005901 caveola 1Yr -1.5 4 Hmox1|P2ry12|Akap6|Ehd2 GO Cellular Components GO:0032432 actin filament bundle 1Yr -1.5 4 Dst|Mprip|Synpo|Pdlim2 GO Cellular Components GO:0043296 apical junction complex 1Yr -1.5 5 Nectin2|Cldn13|Cldn15|Synpo|Nfasc GO Cellular Components GO:0031253 cell projection membrane 1Yr -1.5 8 Akt2|Gnb1|Slc1a2|Utrn|P2ry12|C2cd5|Kirrel|Psd4 GO Molecular Functions GO:0005216 ion channel activity 1Yr -1.5 10 Chrng|Hpn|Kcnj9|Pkdrej|Scn3a|P2rx5|Asic3|Trpv1|Kcnj14|Cngb1 GO Biological Processes GO:0071805 potassium ion transmembrane transport 1Yr -1.5 6 Actn2|Hpn|Kcnj9|P2ry12|Kcnj14|Akap6 GO Biological Processes GO:0071804 cellular potassium ion transport 1Yr -1.5 6 Actn2|Hpn|Kcnj9|P2ry12|Kcnj14|Akap6 GO Biological Processes GO:0007588 excretion 1Yr -1.5 3 Htr7|Kirrel|Trpv1 Reactome Gene Sets R-MMU-2022090 Assembly of collagen fibrils and other multimeric structures 1Yr -1.5 3 Col17a1|Dst|Lama3 GO Cellular Components GO:0042641 actomyosin 1Yr -1.5 4 Dst|Mprip|Synpo|Pdlim2 GO Cellular Components GO:0005912 adherens junction 1Yr -1.5 8 Actn2|Dst|Lama3|Abcb4|Nectin2|Map4k4|Parva|Pdlim2 KEGG Pathway mmu04713 Circadian entrainment 1Yr -1.5 4 Adcy7|Camk2a|Gnb1|Kcnj9 GO Biological Processes GO:0002708 positive regulation of lymphocyte mediated immunity 1Yr -1.5 5 H2-Q4|Klrb1c|Nectin2|Arid5a|H2-M10.5 GO Biological Processes GO:0018393 internal peptidyl-lysine acetylation 1Yr -1.5 5 Tcf3|Trrap|Arrb1|Arid5a|Brd1 GO Biological Processes GO:0044380 protein localization to cytoskeleton 1Yr -1.5 3 Mid1|Anln|4933427D14Rik GO Cellular Components GO:0045171 intercellular bridge 1Yr -1.5 3 Rfxank|Tex14|Ehd2 GO Biological Processes GO:0031343 positive regulation of cell killing 1Yr -1.4 4 H2-Q4|Klrb1c|Nectin2|H2-M10.5 GO Biological Processes GO:0010660 regulation of muscle cell apoptotic process 1Yr -1.4 4 Camk2a|Hmox1|Pde1a|Arrb1 GO Biological Processes GO:0008643 carbohydrate transport 1Yr -1.4 5 Akt2|Enpp1|Slc1a2|C2cd5|Upk3b Reactome Gene Sets R-MMU-418594 G alpha (i) signalling events 1Yr -1.4 9 Adcy7|Fpr2|Gnb1|Pde1a|Npy4r|Rbp3|P2ry12|Tas1r2|Cngb1 GO Biological Processes GO:0050907 detection of chemical stimulus involved in sensory perception 1Yr -1.4 3 Tas1r2|Asic3|Trpv1 GO Biological Processes GO:0006475 internal protein amino acid acetylation 1Yr -1.4 5 Tcf3|Trrap|Arrb1|Arid5a|Brd1 GO Biological Processes GO:0030036 actin cytoskeleton organization 1Yr -1.4 14 Actn2|Capg|Ran|Myadm|Parva|Wipf2|Anln|Ush1c|Synpo|Arrb1|Kirrel|Pdlim2|Gba2|Ehd2 Reactome Gene Sets R-MMU-112315 Transmission across Chemical Synapses 1Yr -1.4 6 Actn2|Adcy7|Camk2a|Gnb1|Kcnj9|Slc1a2 GO Molecular Functions GO:0022838 substrate-specific channel activity 1Yr -1.4 10 Chrng|Hpn|Kcnj9|Pkdrej|Scn3a|P2rx5|Asic3|Trpv1|Kcnj14|Cngb1 GO Cellular Components GO:0045121 membrane raft 1Yr -1.4 9 Ms4a1|Cntn1|Hmox1|Tlr6|Myadm|P2ry12|Kirrel|Akap6|Ehd2 GO Molecular Functions GO:0051219 phosphoprotein binding 1Yr -1.4 4 Mid1|Sh3bp2|Arrb1|Trpv1 GO Cellular Components GO:0098857 membrane microdomain 1Yr -1.4 9 Ms4a1|Cntn1|Hmox1|Tlr6|Myadm|P2ry12|Kirrel|Akap6|Ehd2 GO Molecular Functions GO:0051015 actin filament binding 1Yr -1.4 6 Actn2|Capg|Tnni3|Utrn|Wipf2|Ush1c GO Biological Processes GO:2000377 regulation of reactive oxygen species metabolic process 1Yr -1.4 6 Akt2|Fpr2|Tlr6|Xdh|Ctns|Trpv1 GO Biological Processes GO:1903426 regulation of reactive oxygen species biosynthetic process 1Yr -1.4 4 Akt2|Tlr6|Ctns|Trpv1 GO Biological Processes GO:0009408 response to heat 1Yr -1.4 4 Hmox1|Hsfy2|Asic3|Trpv1 GO Biological Processes GO:1903428 positive regulation of reactive oxygen species biosynthetic process 1Yr -1.4 3 Akt2|Tlr6|Trpv1 Reactome Gene Sets R-MMU-9607240 FLT3 Signaling 1Yr -1.4 6 Actn2|Akt2|Camk2a|Frs3|Arrb1|Rasgrp3 GO Biological Processes GO:0042461 photoreceptor cell development 1Yr -1.4 3 Ush1c|Cngb1|Mir182 GO Cellular Components GO:0005925 focal adhesion 1Yr -1.4 5 Actn2|Dst|Abcb4|Map4k4|Parva GO Biological Processes GO:0002699 positive regulation of immune effector process 1Yr -1.4 7 H2-Q4|Hmox1|Klrb1c|Nectin2|Pgc|Arid5a|H2-M10.5 GO Biological Processes GO:0046579 positive regulation of Ras protein signal transduction 1Yr -1.4 3 F2rl2|Map4k4|Arrb1 GO Biological Processes GO:0018394 peptidyl-lysine acetylation 1Yr -1.4 5 Tcf3|Trrap|Arrb1|Arid5a|Brd1 GO Biological Processes GO:0043967 histone H4 acetylation 1Yr -1.3 3 Tcf3|Trrap|Arrb1 GO Biological Processes GO:0034605 cellular response to heat 1Yr -1.3 3 Hmox1|Hsfy2|Trpv1 GO Biological Processes GO:0002819 regulation of adaptive immune response 1Yr -1.3 6 Adcy7|H2-Q4|Nectin2|Arid5a|H2-M10.5|Il27 GO Biological Processes GO:0030029 actin filament-based process 1Yr -1.3 15 Actn2|Capg|Ran|Myadm|Parva|Wipf2|Anln|Ush1c|Synpo|Arrb1|Kirrel|Pdlim2|Gba2|Akap6|Ehd2 GO Cellular Components GO:0098589 membrane region 1Yr -1.3 9 Ms4a1|Cntn1|Hmox1|Tlr6|Myadm|P2ry12|Kirrel|Akap6|Ehd2 GO Biological Processes GO:0001910 regulation of leukocyte mediated cytotoxicity 1Yr -1.3 4 H2-Q4|Klrb1c|Nectin2|H2-M10.5 GO Biological Processes GO:0006612 protein targeting to membrane 1Yr -1.3 4 Akt2|Zdhhc24|C2cd5|Vps37c GO Biological Processes GO:0150076 neuroinflammatory response 1Yr -1.3 3 Fpr2|Tlr6|Trpv1 GO Biological Processes GO:1901657 glycosyl compound metabolic process 1Yr -1.3 4 Ampd3|Ran|Trmt12|Gba2 GO Cellular Components GO:0005924 cell-substrate adherens junction 1Yr -1.3 5 Actn2|Dst|Abcb4|Map4k4|Parva